PURPOSE: While patients with intermediate-risk (IR) Wilms tumors now have an overall survival (OS) rate of almost 90%, those affected by high-stage tumors with diffuse anaplasia have an OS of only around 50%. We here identify key events in the pathogenesis of diffuse anaplasia by mapping cancer cell evolution over anatomic space in Wilms tumors.EXPERIMENTAL DESIGN: We spatially mapped subclonal la

The boreal landscape stores an estimated 40% of the earth's carbon (C) found in terrestrial vegetation and soils, with a large portion collected in thick organic soil layers. These ground stores are subject to substantial removals due to the centurial return of wildfire, which has strong impacts on the soil microbial community and nutrient cycling, which in turn can control ecosystem recovery patt

The extent to which newly developed blood-based biomarkers could reduce screening costs in secondary prevention trials of Alzheimer's disease is mostly unexplored. We collected plasma amyloid-β42/40, apolipoprotein E ϵ4 status and amyloid PET at baseline in 181 cognitively unimpaired participants [the age of 72.9 (5.3) years; 61.9% female; education of 11.9 (3.4) years] from the Swedish BioFINDER-

How does violent conflict affect the spread of Covid-19? In this paper we analyze how violent conflict influences the adoption of preventative measures and infection rate in a very poor, conflict-affected country, Burkina Faso. We use a unique panel of 1,919 households surveyed during the first six months of the Covid-19 pandemic in 2020 and merge these data with indicators of violence at the muniHow does violent conflict affect the spread of Covid-19? In this paper we analyze how violent conflict influences the adoption of preventative measures and infection rate in a very poor, conflict-affected country, Burkina Faso. We use a unique panel of 1,919 households surveyed during the first six months of the Covid-19 pandemic in 2020 and merge these data with indicators of violence at the muni

Pollen plays a key role in plant reproductive biology. Despite the long history of research on pollen and pollination, recent advances in pollen-tracking methods and statistical approaches to linking plant phenotype, pollination performance, and reproductive fitness yield a steady flow of exciting new insights. In this introduction to the Special Issue “Pollen as the Link Between Phenotype and Fit

Purpose: This article explores how public librarians understand and perform the democratic mission of public libraries in times of political and social turbulence, and critically discusses the idea of public libraries as meeting places.Methodology: Five group interviews conducted with public librarians in southern Sweden are analyzed using a typology of four perspectives on democracy.Findings: TwoPurposeThis article explores how public librarians understand and perform the democratic mission of public libraries in times of political and social turbulence and critically discusses the idea of public libraries as meeting places.Design/methodology/approachFive group interviews conducted with public librarians in southern Sweden are analyzed using a typology of four perspectives on democracy.Fi

State-structured populations are ubiquitous in biology, from the age-structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco-evolutionary dynamics is critical not only for fundamental understanding but also for conservation and treatment purposes. Although some methods have been developed in the literature for modelling eco-evoluti

RNA-directed transposon silencing operates in the mammalian soma and germline to safeguard genomic integrity. The piRNA pathway and the HUSH complex identify active transposons through recognition of their nascent transcripts, but mechanistic understanding of how these distinct pathways evolved is lacking. TASOR is an essential component of the HUSH complex. TASOR's DUF3715 domain adopts a pseudo-

As the world experiences increasing freshwater crises, researchers turn to saline waters. Can the use of saltwater be expanded? The development of appropriate practices for the use of saline waters for irrigation requires an adequate understanding of how salts affect waters, soils and plants, as FAO states in their book The use of saline waters for crop production, 1992. Plants can grow in saline

One novel option for treating metastatic castration resistant prostate cancer is radionuclide therapy targeting prostate-specific membrane antigen (PSMA), e.g. [177Lu]Lu-PSMA-617. Overexpression of HER2 has been found in 80% of metastatic cases of prostate cancer. Previous research showed that HER2 is elevated post irradiation in PC-3 prostate cancer cells. Co-treating with anti-HER2 antibody Tras

Många båtentusiaster skriver under på den romerske fältherren Pompejus bevingade ord navigare necesse est, att segla är nödvändigt. Länge var nöjessjöfarten i svenska farvatten dock förbehållen en privilegierad elit, ända tills fritidsbåtsmodeller, för segel och motor, utvecklades