Benzimidazole units have been grafted onto a polysulfone (PSU) backbone via long alkyl thio–ether chains using a two-step procedure. In the first step, lithiated PSU was reacted with 10-undecenoyl chloride to graft PSU with undecenoyl side chains. The second step involved a free-radical thiol–ene coupling reaction between the C=C bonds of the pendant undecenoyl chains and 2-(2-benzimidazolyl)ethan

Objective: Glucose degradation products (GDPs) in peritoneal dialysis (PD) fluids are cytotoxic and affect the survival of the peritoneal membrane. One of the most reactive GDPs in PD fluids is 3,4-dideoxyglucosone-3-ene (3,4-DGE). 3,4-DGE has been reported as an intermediate between 3-deoxyglucosone (3-DG) and 5-hydroxymethyl furaldehyde (5-HMF) during degradation of glucose. In PD fluids, 3,4-DG

Many small proteins fold in a two-state manner, the rate-limiting step being the passage of the free-energy barrier separating the unfolded state from the native one. The free-energy barrier is, however, weak or absent for the fastest-folding proteins. Here a simple diffusion picture for such proteins is discussed. It is tested on a model protein that makes a three-helix bundle. Assuming the motio

Popular Abstract in Swedish Avhandlingen behandlar vardagslivets resor i staden. Utgångspunkten är de negativa konsekvenser som resor, framför allt med bil, har för miljön. Bilismen är ett fenomen som dominerar stora delar av samhället och istället för att minska i omfattning tycks den själv driva fram ett ökat bilberoende genom att avstånden och kraven på snabba transporter ökar. I slutändan handUrban areas are geographically dispersed. There are built-in distances between housing, jobs and services. These distances call for mobility and fast means of conveyance. Society is dominated by and dependent on motoring. Cars have a negative impact on the environment and prognoses indicate an increase in the amount of travelling. The aim of this dissertation is to explain why travel behaviour wit

This doctoral thesis consists of six studies concerning persons with insulin dependent diabetes mellitus (IDDM). The first two deal with relationships between life events, social support and metabolic control (HbA1C) over a two year period. For the female subjects, results obtained for this period were inconsistent. For the male group, negative life events and poor social support were found to be

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association betwee

After permanent ligation of the middle cerebral artery the motor function of rats housed in an enriched environment, i.e. cages with opportunities for various activities but not forcing the rats to do any particular task, is significantly better than in rats housed in individual cages. Rats kept in an enriched environment before and after MCA ligation improved sooner and slightly more than those p

This thesis comprises general parametric models for surface roughness. The models can be used in several technical and natural applications but are here only applied to the micro-structure of paper. In that application, earlier models are generalized and new models introduced. The different models are related to the scale of the roughness and by using different approaches, different roughness prop

An optimization approach to a multi-dimensional acoustic inverse problem in the time domain is considered. The density and/or the sound speed are reconstructed by minimizing an objective functional. By introducing dual functions and using the Gauss divergence theorem, the gradient of the objective functional is found as an explicit expression. The parameters are then reconstructed by an iterative

Objective. The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-ben zene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis. Methods. Arthritis was induced by injection of Mycobacterium butyricum into the right hindpaw. Inflammatory paramet