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Anorexia nervosa is a chronic, progressive illness that is difficult to treat. Four years after diagnosis, less than 50% of patients have recovered, and 25% of anorexic patients progress to chronicity and invalidism. Because anorexia nervosa typically begins in adolescence, teenagers should be watched closely for signs that may reflect an eating disorder. In the early stages of the disease, though
The development of selective serotonin reuptake inhibitors and atypical antidepressants has changed the treatment of depression significantly. Newer antidepressants lack many of the side effects associated with the monoamine oxidase inhibitors (isocarboxazid, for example) and the tricyclic antidepressants, thereby increasing patient compliance. They are also less dangerous in overdose and are ofte
The term demoralization has been used to describe existential distress and despair of patients with advanced disease. Aim: This study sought to determine whether a cluster of symptoms interpreted as demoralization could be identified and distinguished from a cluster of depressive symptoms. Materials and Methods: As part of the Coping with Cancer Study, a federally funded multi-site study of advanc
Background: Summary statistics often hide individual patients' suffering, thereby impeding quality improvement efforts. Objectives: We aimed to show the experience of a population with health care toward the end of life while preserving the experience of the individual. Design: We developed a data display method called per-patient illness trajectory analysis. We tested it using a demonstration coh
Familial isolated GH deficiency type II (IGHD-II) is an autosomal dominant disorder that has been previously shown in some patients to be caused by heterogeneous GH gene defects that affect GH messenger RNA (mRNA) splicing. We report here our finding of multiple G-->A transitions of the first base of the donor splice site of IVS 3 (+ 1G-->A) in IGHD II subjects from three nonrelated kindreds from
OBJECTIVES: To examine cardiovascular autonomic function in middle-aged people with long-term cervical and upper thoracic spinal cord injury (SCI) compared with the general population, and explore if the neurological level of injury (NLI) is related to cardiovascular autonomic function.DESIGN: Population-based cross-sectional study with matched controls.SETTING: Outpatient SCI unit in Southern Swe
In this study, we investigated the prevalence of mental disorders and the use of psychopharmacologic drugs among individuals with cerebral palsy (CP). We studied how the association between CP and mental illness develops over the life course (between ages 5 and 65 years), and how it varies across disability specific factors (intellectual disability, gross motor function and communicative ability).
Background: This project plan proposes a new learning activity and assessment model of medical students' empathy and communication skills. An empathic ability and communication skills are crucial in a student future role as a physician. Empathy and communication skills are also Entrustable Professional Activities in most undergraduate medical educational programs1.Method: The students are first in
Recently, it has been proposed that the luminescence sensitivity of quartz grains, i.e. their luminescence response to unit dose, might be used for sediment fingerprinting. Sensitivity is determined both by the origin of quartz grains and the sedimentary processes they underwent. However, a more detailed understanding of the factors influencing sensitivity is essential in order to expand and speci
Turner syndrome (TS) is a genetic condition characterized by partial or complete monosomy X. A reduced life expectancy has been shown in TS, depending on an increased risk of aortic dissection, and ischemic heart disease. Studies covering the occurrence of psychiatric conditions are sparse within TS. Several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent
Hemozoin (Hz) is a heme crystal produced during malaria infection that stimulates immune cells, leading to the production of cytokines and chemokines. The immunostimulatory action of Hz has previously been applied in the development of alternative adjuvants. Crystallization of hemin is a chemical approach for producing Hz. Here, we focused on an enzymatic production method for Hz using the heme de
Background: The tumoricidal complex alpha1-oleate targets bladder cancer cells, triggering rapid, apoptosis-like tumor cell death. Clinical effects of alpha1-oleate were recently observed in patients with non-muscle invasive bladder cancer (NMIBC), using a randomized, placebo-controlled study protocol. Aims: To investigate if there are dose-dependent effects of alpha1-oleate. Materials and Methods
This comparative study delves into the intricate challenges surrounding stigma within active labor market programs (ALMPs) and its implications for work, wellbeing, and social policy. In both Sweden and Australia, employers exhibit reluctance to draw from this candidate pool for recruitment. Understanding employers' reasons for not utilising ALMP candidates, their expectations from candidates, and
When deploying deep neural networks on robots or other physical systems, the learned model should reliably quantify predictive uncertainty. A reliable uncertainty allows downstream modules to reason about the safety of its actions. In this work, we address metrics for uncertainty quantification. Specifically, we focus on regression tasks, and investigate Area Under Sparsification Error (AUSE), Cal
