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A distortional hardening model for finite plasticity

Plastic anisotropy may strongly affect the stress and strain response in metals subjected to multiaxial cyclic loading. This anisotropy evolves due to various microstructural features. We first use simple models to study how such features result in evolving plastic anisotropy. A subsequent analysis of existing distortional hardening models highlights the difference between stress- and strain-drive

Early Cambrian brachiopod-dominated shell concentrations from North-East Greenland : Environmental and taphonomic implications

The occurrence of a series of thin but persistent early Cambrian (Cambrian Age 4) brachiopod shell concentrations extending along a transect of some 150 km in NE Greenland, indicates the ability of the group to form widespread, skeletal pavements very early in the history of the phylum, its gregarious behaviour and ability to harness available nutrients. These extensive shell pavements within the

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role in the pathological process of PD are unclear. In the present study, we investigated the effects of

The challenges of the expanded availability of genomic information : an agenda-setting paper

Rapid advances in microarray and sequencing technologies are making genotyping and genome sequencing more affordable and readily available. There is an expectation that genomic sequencing technologies improve personalized diagnosis and personalized drug therapy. Concurrently, provision of direct-to-consumer genetic testing by commercial providers has enabled individuals' direct access to their gen

Female behaviour is differentially associated with specific components of multimodal courtship in ring doves

Courtship displays are typically conspicuous, elaborate and composed of concomitant signals occurring in different sensory modalities. Although multimodal signals have received increasing attention over the past years, technical issues, in particular the lack of appropriate recording and analytical methods, have long restricted large-scale systematic study of their function. Here, we investigated

Solar Activity of the Past 100 Years Inferred From 10Be in Ice Cores—Implications for Long-Term Solar Activity Reconstructions

Differences between 10Be records from Greenland and Antarctica over the last 100 years have led to different conclusions about past changes in solar activity. The reasons for this disagreement remain unresolved. We analyze a seasonally resolved 10Be record from a firn core (North Greenland Eemian Ice Drilling [NEEM] ice core project) in Northwestern Greenland for 1887–2002. By comparing the NEEM d

Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited b

Gardens’ contribution to people and urban green space

Cities are experiencing numerous challenges, adversely affecting human health and wellbeing. Urban green space provides ecosystem services that are important to meet urban challenges. One type of urban green space is private gardens (yards) that make up an essential part of many urban areas. Gardens can support urban biodiversity and provide cultural ecosystem services (CES) to its owner. However,

Flow cytometric analysis reveals culture-condition dependent variations in phenotypic heterogeneity of Limosilactobacillus reuteri

Industrial production of probiotic bacteria must be adapted to reach a stable product with resistance to unfavourable environmental conditions during storage and that display probiotic functionality. Flow cytometry-based descriptors, light scatter and pulse width of bacterial morphology were used as markers to estimate physiological fitness. The effects of temperature, pH and oxygen levels on cell

The kraptr of aging folk musicians : Mental practice for the future

This chapter rests on participant observation and interviews from Malungs folkhögskola, the distance education “Folkmusik fiol”, led by the doyen of Swedish folk music pedagogy, Jonny Soling. With his life-long experience of fiddle education for grown-ups, Soling has unique knowledge of holistic fiddle didactics. At the age of 73, he still attracts course participants from all ages and all parts o

Drone-based hyperspectral and thermal imagery for quantifying upland rice productivity and water use efficiency after biochar application

Miniature hyperspectral and thermal cameras onboard lightweight unmanned aerial vehicles (UAV) bring new opportunities for monitoring land surface variables at unprecedented fine spatial resolution with acceptable accuracy. This research applies hyperspectral and thermal imagery from a drone to quantify upland rice productivity and water use efficiency (WUE) after biochar application in Costa Rica

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer : A Review

Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant t