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The effect of two types of minimal acupuncture on stooling, sleeping and feeding in infants with colic : secondary analysis of a multicentre RCT in Sweden (ACU-COL)

Background: Evidence for the effect of minimal acupuncture in infants with colic is limited. Aim: To compare the effect of standardized minimal acupuncture, individualized acupuncture (where traditional acupuncture points were chosen according to the infant’s symptoms) and no acupuncture on objective measures of stooling, feeding and sleeping in infants with colic (based on diaries) and perceived

Levodopa infusion in Parkinson's disease : Individual quality of life

Objectives: Parkinson's disease (PD) features both motor and non-motor symptoms that substantially impact quality of life (QoL). Levodopa-carbidopa intestinal gel (LCIG) reduces motor complications and improves some non-motor symptoms in advanced PD (APD). Change in patients' health-related quality of life (hrQoL) is a common endpoint in PD trials and has become an important factor in judging over

National e-library for standardized chemotherapy regimens

The aim was to develop a method, an e-library, with standardized nomenclature and content in chemotherapy regimens. In developing the method, an iterative improvement process was applied, following a PDSA Cycle (Plan, Do, Study, Act). The entire process of developing the e-library was documented, through e.g. meeting notes and e-mail archives. The development process used participatory design, inv

Bogong Moths Are Well Camouflaged by Effectively Decolourized Wing Scales

Moth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct rMoth wings are densely covered by wing scales that are assumed to specifically function to camouflage nocturnally active species during day time. Generally, moth wing scales are built according to the basic lepidopteran Bauplan, where the upper lamina consists of an array of parallel ridges and the lower lamina is a thin plane. The lower lamina hence acts as a thin film reflector having distinct reflec

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

The bifunctional human enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) catalyzes two essential steps in the de novo purine biosynthesis pathway. PAICS is overexpressed in many cancers and could be a promising target for the development of cancer therapeutics. Here, using gene knockdowns and clonogenic survival and cell viability