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This thesis has focused on the development of methods and their applications for the identification of antibodies reactive with tumor associated antigens (TAA). The phage display technology provides a powerful mean to generate antibodies potentially useful for tumor immunotherapy. A phage antibody displays on its surface an antibody fragment encoded by a gene inserted in the phage genome. The phag
The aim of this programme is to contribute to the scientific and practical knowledge about continuous improvements (CI) at work. Some of the principles of CI like: the emphasis on small and incremental changes, the use of structured tools for problem-solving and the monitoring of improvements, and the responsibility of operative personnel for the CI activity rather than experts and task-forces, ar
Otoliths, or earstones, are small, biogenic concretions of aragonitic calcium carbonate precipitated on a protein matrix. Otoliths form part of the hearing and balance system in teleost fishes, and grow as the fish grow, providing a continuous biochronology of growth. Various elements are entrained in minor and trace quantities. In particular, strontium is a useful scalar of habitat use when varia
Popular Abstract in Swedish I denna avhandling diskuteras olika aspekter av tillverkning av nanostrukturer med nanoimprint litografi (NIL). Detta är en relativt ny metod som möjliggör snabb tillverkning av högupplösta strukturer på stora ytor. För att skapa dessa strukturer med NIL använder man sig av mekanisk deformation av mönstringsmaterialet. Detta skiljer sig från de mer etablerade mönstringsThis thesis describes different aspects of nanotechnology manufacturing with nanoimprint lithography (NIL), a relatively new nanofabrication tool capable of high resolution and high throughput. Surface structure creation with NIL is based on mechanical deformation of the patterning material. This is radically different from the two main established methods, ultra violet lithography (UVL) and elect
Two-particle azimuthal correlation functions are presented for charged hadrons produced in Au+Au collisions at the Relativistic Heavy Ion Collider (sqrt[sNN]=130 GeV). The measurements permit determination of elliptic flow without event-by-event estimation of the reaction plane. The extracted elliptic flow values (v2) show significant sensitivity to both the collision centrality and the transverse
This study investigated if clothing material with reflective properties has an effect on heat gain in pilot, specifically, under solar radiation. Two materials, conventional pilot suit material (Old) and material coated with coldblack® (New, Schoeller Technologies AG, Switzerland) were tested over variety of underwear layers and in a box simulating cockpit. A hot plate was used to measure textile
Lattice decoders for MIMO systems, including the sphere decoder (SD) and the Schnorr-Euchner (SE) decoder, have been shown to approach the performance of Maximum-likelihood decoder with low complexity. There are three kinds of lattice decoder, sequential SD, K-best SD and sequential SE, which are popular in the literature. As a modification to the K-best SD, a lower complexity K-best SE is propose
BackgroundRespiratory diseases are the most common cause for seeing a doctor in Nicaragua, and the second most common cause of death in children. An air monitoring program in the capital city, Managua, has shown high levels of air pollution, especially small particles. Important sources for this pollution are road traffic, smoke from cooking with wood, from burning of sugar cane fields before harv
Abstract is not available
Popular Abstract in Swedish Svensk sammanfattning Inflammation är kroppens svar på yttre störning. Det inflammatoriska svaret är nödvändigt för att bekämpa infektioner, t.ex. med bakterier. Å andra sidan orskar det inflammatoriska svaret mycket skada när det aktiveras utan närvaro av infektioner, tex vid astma, reumatism, blodförgiftning och inflammatorisk tarmsjukdom. Akut inflammation karaktäriMigration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. Tumor necrosis factor-alpha (TNF-alpha) is pleiotrophic cytokine, which plays an important role in t
“Die Unruhe und Ungewissheit sind unser Theil”, writes Goethe in a letter to the German novelist Sophie von la Roche in 1774. But is it the incalculable and indeterminate that cause disquiet, or is it our bustling pursuit of knowledge that makes us uncertain? Contemporary psychologists have taught us a great deal about the way we perceive risks and about the way affects and emotions influence our
Miniaturized (<1 L) biospecific affinity two-phase partitioning in an acoustically levitated drop is described. Miniaturization commonly gives unfavorable surface/volume ratios, but in the levitation approach adsorption problems are minimized since the only surrounding wall is the liquid/air interface of the drop. Biotinylated liposomes were partitioned in aqueous poly(ethylene glycol)/dextran two
