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LDL subfractions are associated with incident cardiovascular disease in the Malmö Prevention Project Study

Background and aims After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lip

Assessing hydration disturbances from concrete aggregates with radiation shielding properties by isothermal calorimetry

Spallation sources create a large amount of neutrons with energies up to the GeV range. To shield for these neutrons, steel and concrete are important materials. By adding different aggregates to normal concrete, one can improve the shielding effect of the concrete. Some of these aggregates can influence the rate of hydration (reaction) of the cement or even completely inhibit the hydration. It is

Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain

The Drosophila antenna contains receptor neurons for mechanical, olfactory, thermal, and humidity stimuli. Neurons expressing the ionotropic receptor IR40a have been implicated in the selection of an appropriate humidity range [], but although previous work indicates that insect hygroreceptors may be made up by a "triad" of neurons (with a dry-, a cold-, and a humid-air-responding cell []), IR40a

Novel Genetic Variants in BAG3 and TNNT2 in a Swedish Family with a History of Dilated Cardiomyopathy and Sudden Cardiac Death

Familial dilated cardiomyopathy is a rare cause of dilated cardiomyopathy (DCM), especially in childhood. Our aim was to describe the clinical course and the genetic variants in a family where the proband was a four-month-old infant presenting with respiratory problems due to DCM. In the family, there was a strong family history of DCM and sudden cardiac death in four generations. DNA was analyzed

Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway

Subarachnoid hemorrhage (SAH) is a serious clinical condition where leakage of blood into the subarachnoid space causes an acute rise in intracranial pressure and reduces cerebral blood flow, which may lead to delayed cerebral ischemia and poor outcome. In experimental SAH, we have previously shown that the outcome can be significantly improved by early inhibition of the MAPK/ERK kinase/extracellu

New results related to QGP-like effects in small systems with ALICE

Results on the production of π±, K±, p(p), Λ(Λ), Ξ- (Ξ+) and Ω- (Ω+) at midrapidity (/y/ < 0.5) as a function of multiplicity in √ s = 7 TeV pp collisions are reported. Transverse momentum distributions and integrated yields are compared to expectations from statistical hadronization models along with results from different colliding systems and center-of-mass energies. The evolution of spectral s

On a radiative origin of the standard model in non-supersymmetric trinification with global SU(3)F

We present a trinification-based grand unified theory incorporating a global SU(3)F family symmetry, that after spontaneous symmetry breaking leads to a left-right symmetric model. In addition to unification of gauge couplings, the model unifies Yukawa interactions and contains equivalent representations in the scalar and fermion sectors at high energy scales. Considering the minimal low-energy sc

Reviews and syntheses : Systematic Earth observations for use in terrestrial carbon cycle data assimilation systems

The global carbon cycle is an important component of the Earth system and it interacts with the hydrology, energy and nutrient cycles as well as ecosystem dynamics. A better understanding of the global carbon cycle is required for improved projections of climate change including corresponding changes in water and food resources and for the verification of measures to reduce anthropogenic greenhous

Dynamic Server Provisioning with Queue Stabilization in Data Centres

When load balancing data centres with all serversactive to serve jobs, the result can be excessive energy usage. Onthe other hand, using dynamic server provisioning, the numberof servers that serve requests can be reduced by turning off idleservers and thereby save energy. However, such a scheme, usuallyincreases the risk of instability of server queues. In this work,we analyze the trade-off betwe

Hepcidin levels and gastric cancer risk in the EPIC-EurGast study

Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control stud

Lead(ii) soaps : Crystal structures, polymorphism, and solid and liquid mesophases

The long-chain members of the lead(ii) alkanoate series or soaps, from octanoate to octadecanoate, have been thoroughly characterized by means of XRD, PDF analysis, DSC, FTIR, ssNMR and other techniques, in all their phases and mesophases. The crystal structures at room temperature of all of the members of the series are now solved, showing the existence of two polymorphic forms in the room temper

Redox-Driven Migration of Copper Ions in the Cu-CHA Zeolite as Shown by the InSitu PXRD/XANES Technique

Using quasi-simultaneous insitu PXRD and XANES, the direct correlation between the oxidation state of Cu ions in the commercially relevant deNOx NH3-SCR zeolite catalyst Cu-CHA and the Cu ion migration in the zeolitic pores was revealed during catalytic activation experiments. A comparison with recent reports further reveals the high sensitivity of the redox-active centers concerning heating rates

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

The coaggregation of the amyloid-β peptide (Aβ) and α-synuclein is commonly observed in a range of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. The complex interplay between Aβ and α-synuclein has led to seemingly contradictory results on whether α-synuclein promotes or inhibits Aβ aggregation. Here, we show how these conflicts can be rationalized and resolved by de

Trends in treatment with antipsychotic medication in relation to national directives, in people with dementia - a review of the Swedish context

Background: The aim of this study was to explore trends in treatment with antipsychotic medication in Swedish dementia care in nursing homes as reported in the most recent empirical studies on the topic, and to relate these trends to directives from the national authorities. Methods: The study included two scoping review studies based on searches of electronic databases as well as the Swedish dire

Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes

Background: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable effective breathing. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volu

Clonal Hematopoiesis and risk of atherosclerotic cardiovascular disease

BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular diseas