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The effects of an acceleration advisory tool in vehicles for reduced fuel consumption and emissions

This study evaluates whether the use of an acceleration advisor leads to fuel savings, to determine the change in traffic-related emissions and to analyse changes in driving patterns on various routes. The acceleration advisor provides advice to drivers through resistance in the accelerator pedal when they try to accelerate rapidly. In a test carried out in Southern Sweden, the acceleration adviso

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This paper discusses how the author, a Japanese expatriate living in Sweden, perceives packaging in Sweden. Concentrating primarily on the cultural aspect, the paper focuses on the similarity and differences found in 1) the usage of packaging as well as 2) source separation systems for packaging waste. Concerning the usage, the main differences are found in the way packaging is used to keep the qu

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.

Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of funct

Application of an anisotropic growth and remodelling formulation to computational structural design

A classical structural optimisation problem consists of a problem-specific objective function which has to be minimised in consideration of particular constraints with respect to design and state variables. In this contribution we adopt a conceptually different approach for the design of a structure which is not based on a classical optimisation technique. Instead, we establish a constitutive micr

Network-level analysis of light adaptation in rod cells under normal and altered conditions

Photoreceptor cells finely adjust their sensitivity and electrical response according to changes in light stimuli as a direct consequence of the feedback and regulation mechanisms in the phototransduction cascade. In this study, we employed a systems biology approach to develop a dynamic model of vertebrate rod phototransduction that accounts for the details of the underlying biochemistry. Followi

Direct Demonstration of Influenza Virus and Mycoplasma Pneumoniae in the Respiratory Tract

Popular Abstract in Swedish Inledning I detta avhandlingsarbete studeras Mycoplasma pneumoniae (MP) och influensa virus ur olika perspektiv. Dessa två smittämnen orsakar båda årliga utbrott med luftvägsinfektioner som ibland blir omfattande epidemier. I båda fallen kan symptomen variera från lätta förkylningsbesvär till mycket svåra, ibland livshotande lunginflammationer. Infektion med MycoplasmaDiagnostic tests based on nucleic acid amplification have become available for Mycoplasma pneumoniae (MP) and influenza viruses. Here, an MP PCR test detected 100% of infections during the first three symptomatic weeks, whereas classical serology detected 21% week 1, 56% week 2, and 100% week 3. Positive PCR results were uncommon in healthy individuals. Levels of MP DNA were significantly higher i

Microanatomical and Histological Features in the Long Bones of Mosasaurine Mosasaurs (Reptilia, Squamata) - Implications for Aquatic Adaptation and Growth Rates

Background: During their evolution in the Late Cretaceous, mosasauroids attained a worldwide distribution, accompanied by a marked increase in body size and open ocean adaptations. This transition from land-dwellers to highly marine-adapted forms is readily apparent not only at the gross anatomic level but also in their inner bone architecture, which underwent profound modifications. Methodology/P

Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

Objective:To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD).Methods:From the prospective, longitudinal BioFINDER study, we included 122 healthy elderly and 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). -Amyloid (A) deposition in 9 brain regions was examined with [F-18]-flutemetamol

Method for evaluating learning from incidents using the idea of "level of learning"

Learning from incidents is considered a very important source for learning and improving safety in the process industries. However, the effectiveness of learning from reported incidents can often be ques-tioned. Therefore, there is a need to be able to evaluate the effectiveness of learning from incidents, and for that purpose we need methods and tools. In this paper, a method is described for eva

Biomass fuel use and the risk of asthma in Nigerian children

Background: Biomass fuel smoke exposure contributes to respiratory infections in childhood, but its association with asthma has not been established. We studied the relationship of biomass fuel use with asthma symptoms and lung function in Nigerian children. Methods: A cross-sectional study was performed in 299 village children aged 5-11 years in North Central Nigeria. Data were collected regardin

A toxicological and dermatological assessment of macrocyclic lactone and lactide derivatives when used as fragrance ingredients

The Macrocyclic Lactone and Lactide derivative (ML) group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.47% to 11.15%; systemic exposures vary from 0.0008 to 0.25 mg/kg/day. The MLs had low acute toxicity and no significant toxicity in repeat dose oral ordermal toxicity studie

Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.

Despite more than 25 years of research, the molecular targets of quinoline-3-carboxamides have been elusive although these compounds are currently in Phase II and III development for treatment of autoimmune/inflammatory diseases in humans. Using photoaffinity cross-linking of a radioactively labelled quinoline-3-carboxamide compound, we could determine a direct association between human S100A9 and