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The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. The aim of our study was to

Extraction systems for hydrophobically tagged proteins have been developed based on phase separation in aqueous solutions of non-ionic detergents and polymers. The systems have earlier only been applied for separation of membrane proteins. Here, we examine the partitioning and purification of the amphiphilic fusion protein endoglucanase I(core)-hydrophobin I (EGI(core)-HFBI) from culture filtrate

Background: Cellular interactions elicited by Plasmodium falciparum erythrocyte membrane protein antigen 1 (PfEMP1) are brought about by multiple DBL ( Duffy binding like), CIDR ( cysteine-rich interdomain region) and C2 domain types. Elucidation of the functional and structural characteristics of these domains is contingent on the abundant availability of recombinant protein in a soluble form. A

Aim. - To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes. Methods. - We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study

Background: CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains are poorly understood. To better understand envelope glycoprotein (Env) determinants contributing to pathogenicity of R5 viruses, we characterized 37 full-length R5 Envs from cross

Popular Abstract in Swedish Det råder delade meningar om hur man bäst tar hand om patienter med lindrig primär hyperparatyreoidism (PHPT), dvs. överfunktion i en eller flera av de fyra bisköldkörtlarna med endast lätt förhöjning av kalciumnivån i blodet. Det finns de som förordar operation, medan andra anser att det inte behövs någon behandling så länge sjukdomen inte förvärras. Syftet med det aktThere is an ongoing controversy regarding how to take care of patients with mild primary hyperparathyroidism (PHPT). Some recommend surgical treatment at diagnosis, others just follow-up as long as there is no evidence of disease progression. The aim of this thesis was to evaluate cardiac and skeletal risk factors related to the duration of mild PHPT. Fifty patients with mild PHPT were randomized

When formulating a policy related to food in a heterogeneous context within a nation or between nations, oppositional positions are more or less explicit, but always have to be overcome. It is interesting to note, though, that such elements as culture and religion have seldom been the focus in discussions about methods of decision-making in food policy. To handle discrepancies between oppositional

Linear-transmitters based on combined analog locked loop universal modulator (CALLUM) architectures are attractive, as they promise both high efficiency and high linearity. To date, it has not been possible to analyze a CALLUM transmitter as a linear feedback network due to the nonlinear nature of the control equations governing it. The main purpose of this paper has been the derivation of a linea

There is no consensus on the treatment of congenital diaphragmatic hernia (CDH), and practice seems to vary between centres. The main purpose of the present study was to survey current practice in Scandinavia. Thirteen paediatric surgical centres serving a population of about 22 million were invited, and all participated. One questionnaire was completed at each centre. The questionnaire evaluated

We derive a partition function for the Lund fragmentation model and compare it with that of a classical gas. For a fixed rapidity “volume” this partition function corresponds to a multiplicity distribution which is very close to a binomial distribution. We compare our results with the multiplicity distributions obtained from the JETSET Monte Carlo for several scenarios. Firstly, for the fragmentat

Adsorption chromatography in expanded beds is a widely used technology for direct capture of target proteins from fermentation broths. However, in many cases this method cannot be applied as a result of the strong tendency of cells or cell debris to interact with the adsorbent beads. To prevent contamination of the expanded bed with the biomass, STREAMLINE DEAE, anion exchanger designed for expand

Albeit there is a general consensus that urban design in the twentieth century failed in relation to space use, systematic research on this aspect has been very limited or at most inadequate in the developing countries. This study focuses on the above failure of urban design in this century with specific reference to the developing countries through an analysis of Dar es Salaam city centre, Tanzan

Electronic and atomic structure of hexagonal boron nitride (h-BN) on lattice-mismatched transition metal surfaces has been studied systematically by X-ray absorption and photoelectron spectroscopy and diffraction. The strength of interfacial chemical interaction between h-BN and the substrates is rising in the row Pt(111)-Ir(111)-Rh(111)-Ru(0001). This rise directly correlates with a growing corru