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Europe’s Beating Cancer Plan is a substantial European Union (EU) investment into cancer prevention and treatment. Integration of genetic services towards personalised cancer prevention and care is a flagship of this plan. Genetic counselling is critical to this integration, facilitating informed patient decision making and improved clinical management. However, growing demands for genetic testing
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airway remodeling, including emphysema and fibrosis. Proteoglycans and their glycosaminoglycan (GAG) chains are key components of the extracellular matrix and may be altered as the disease advances. This study analyzed lung tissue from COPD patients (GOLD stages II-III and IV), non-COPD smokers, and non-smoker
BACKGROUND: Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard® system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD manageme
BACKGROUND: Post COVID-19 condition remains a complex and challenging issue, with diverse manifestations, despite accumulating research and clinical experience. Dyspnea is one of the most common symptoms reported in post COVID-19 condition. Cardiopulmonary exercise testing (CPET) offers a cohesive assessment of dyspnea and exercise limitations. The Nijmegen questionnaire is a form for assessment o
Background: Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications. Methods: This was a retrospective obser
Background: Non-motor symptoms (NMS) substantially impair quality of life in Parkinson's disease (PD) patients, yet treatment gaps persist. Guideline adherence for NMS management remains poorly characterised. Also, reliable symptom monitoring tools are needed: the Parkinson’s KinetiGraph (PKG) for sleep assessment and the Home Diary (HD) for motor fluctuations both require further validation.Aims:
We explore mission assignment and task offloading in Open Radio Access Network (Open RAN)-enabled intelligent transportation systems (ITS), where autonomous vehicles utilize mobile edge computing for efficient processing. Existing studies often overlook mission dependencies and offloading costs, leading to suboptimal decisions. To address this, we formulate a novel optimization problem that integr
Maternal alloantibody-induced hemolytic disease of the fetus and newborn (HDFN) remains a significant concern worldwide. Alloimmune HDFN can be pathogenetically named by the specific alloantibodies involved. Moreover, four mechanistic pathway types are generally recognized in clinical practice: classical or extravascular hemolysis; immune-pressure-escaped, also known as antibody-mediated antigen-m
Context. Massive contact binaries (CBs) are crucial objects for understanding close binary evolution and stellar mergers. Study of these objects has been hampered by a scarcity of observed systems, particularly of B-type systems which are expected to dominate this class. Aims. We bridge this observational gap by mining a large sample of massive CB candidates from the OGLE-IV database, potentially
Vision impairment increases risks such as social isolation, mobility challenges, and falls. Wearable Augmented Reality (AR) devices with Artificial Intelligence (AI) can enhance sensory perception by enabling real-time recognition of obstacles, assisting visually impaired individuals during street navigation, aiming to reduce the risk of falls. In this paper, we propose a Federated Learning (FL) f
We study the nonlinear and resonant process of two-photon ionization of atoms (He and H) in a pump-probe scheme. The pump pulse prepares the quantum system in a superposition of the ground state and an excited bound state. By varying the phase difference between the pulses, we show how it is possible to coherently control the dressed-state population during the probe pulse. Our main result is that
Due to the threat climate change poses, the aviation industry needs to adapt. In the process to convert the aviation fleet into a more environmentally friendly fleet, using biofuels such as Sustainable Aviation Fuels as a drop-in fuel remains a promising option. To include biofuels, safety aspects need to be investigated, where combustion instabilities are important. Thermo-acoustic instabilities
Atomic layer deposition (ALD) of interphases is a promising strategy for stabilizing lithium metal negative electrode and mitigating dendrite formation in rechargeable batteries. In this work, we investigate the growth mechanism and electrochemical impact of titanium-based ALD coatings on highly reactive lithium surfaces. Operando ambient-pressure X-ray photoelectron spectroscopy (APXPS) was emplo
This paper examines the role of system-level agency in shaping green transitions in peripheral regions. The comparative case study analysis of four peripheral regions in Germany reveals significant differences in capacities to address challenges, overcome dependencies and seize green opportunities. It showcases how intermediaries function as conducive actors that unlock regional transition process
Jerome of Stridon was one of the most important biblical exegetes in early Christianity. Analyzing letters as well as prefaces to biblical commentaries written by Jerome, this article discusses four criteria which he considered to be necessary for orthodox exegesis to take place: 1) education and learning; 2) studying the Scriptures as part of an ascetic lifestyle; 3) divine help; and 4) learning
Ultra-hot gas giants such as WASP-121b provide unique laboratories for exploring atmospheric chemistry and dynamics under extreme irradiation conditions. Uncovering their chemical composition and atmospheric circulation is critical for tracing planet formation pathways. Here, we present a comprehensive atmospheric characterisation of WASP-121b using high-resolution transit spectroscopy across the
This discussion paper recognizes that the Glasgow Consensus Statement is not optimally useful unless it is disseminated widely. Knowledge and use of the consensus statement and its call for centering humanism in healthcare extend to medical and health organizations and groups beyond the International Conference on Communication in Healthcare and Patient Education and Counseling audiences, to profe
The growing vulnerability of cities to extreme heat underscores the urgency of effective urban adaptation policies. Despite the progress in developing urban climate policies and strategies, there remains a significant disparity between intended goals and actual outcomes. This could entrench social and climate vulnerabilities that are costly and challenging to address, potentially resulting in rein
