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Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia

Introduction and hypothesis: Bilateral pelvic nerve injury (BPNI) is a model of post-radical hysterectomy neuropraxia, a common sequela. This study assessed the time course of changes to detrusor autonomic innervation, smooth muscle (SM) content and cholinergic-mediated contraction post-BPNI. Methods: Female Sprague–Dawley rats underwent BPNI or sham surgery and were evaluated 3, 7, 14, and 30 day

PID synthesis under probabilistic parametric uncertainty

In many system identification methods, process model parameters are considered stochastic variables. Several methods do not only yield expectations of these, but in addition their variance, and sometimes higher moments. This paper proposes a method for robust synthesis of the proportional-integral-derivative (PID) controller, taking parametric process model uncertainty explicitly into account. The

Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy : Replication of the Reported Candidate Susceptibility Loci

The introduction of proteasome inhibitors in the treatment of multiple myeloma (MM) patients has been a therapeutic success. Peripheral neuropathy (PNP) remains one of the most frequent side-effects experienced by patients who receive these novel agents. Recent investigations on the mechanisms of PNP in patients treated with bortezomib have suggested genetic susceptibility to neurotoxicity. We use

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L’article discute des pratiques d’engagement et de développement de littératies menées par un réseau debibliothèques scolaires et publique intégrées, dans un quartier urbain multiethnique en Suède. La discussion traite enparticulier les modalités de collaboration avec l’école, les familles, les associations, les centres de loisirs et autres acteursdu quartier, ainsi que les stratégies mises en pla

Nyanlända studenters behov av utbildning : Möjligheter och hinder

Refugees arrive in Sweden in connection with wars and repressive conditions in their countries of origin or refuge. Recently, many have come from the Middle East, and Syria in particular. The situation of refugees has a wide range of consequences for education in the host country, including higher education. Validation and admissions procedures involve administrative challenges, and language is an

Equilibria, Kinetics and Mechanism for Complex Formation Between Hydrogen Sulfate/Sulfate and Palladium(II). Hydrolysis of Tetraaquapalladium(II)

Spectrophotometric equilibrium measurements indicate formation of the complexes [Pd(H2O)(3)HSO4](+) and [Pd(H2O)(3)SO4] in the reaction between [Pd(H2O)(4)](2+) and hydrogen sulfate/sulfate in the region: 0.10 less than or equal to [H+] less than or equal to 0.80 M. The stability constants are 0.7 +/- 0.2 and 19 +/- 6 M-1, respectively, at 25 degrees C and 1.00 M ionic strength. The protolysis con

Occupational sedentariness and breast cancer risk

Background: Epidemiological studies have indicated that physical activity reduces the risk of developing breast cancer. More recently, sedentary behavior has been suggested as a risk factor independent of physical activity level. The purpose of the present study was to investigate occupational sedentariness and breast cancer risk in pre- and postmenopausal women. Materials and methods: In a popula

Double vector meson production in photon–hadron interactions at hadronic colliders

In this paper we analyze the double vector meson production in photon–hadron (γh) interactions at pp / pA / AA collisions and present predictions for the ρρ, J/ Ψ J/ Ψ , and ρJ/ Ψ production considering the double scattering mechanism. We estimate the total cross sections and rapidity distributions at LHC energies and compare our results with the predictions for the double vector meson production

PON-Sol : Prediction of effects of amino acid substitutions on protein solubility

Motivation: Solubility is one of the fundamental protein properties. It is of great interest because of its relevance to protein expression. Reduced solubility and protein aggregation are also associated with many diseases. Results: We collected from literature the largest experimentally verified solubility affecting amino acid substitution (AAS) dataset and used it to train a predictor called PON

Effective dose in low-dose CT compared with radiography for templating of total hip arthroplasty

Background Recently, total hip arthroplasty (THA) has come to focus on restoration of individual anatomy including femoral neck anteversion and global offset (femoral and acetabular offset). Three-dimensional (3D) computed tomography (CT) data could provide a better basis for preoperative templating. The use of CT has been hampered by high radiation dose. Purpose To evaluate the effective dose us

Aerosol indirect effects on glaciated clouds. Part 2 : Sensitivity tests using solute aerosols

Sensitivity tests were performed on a midlatitude continental case using a state-of-the-art aerosol–cloud model to determine the salient mechanisms of aerosol indirect effects (AIE) from solute aerosols. The simulations showed that increased solute aerosols doubled cloud-droplet number concentrations and hence reduced cloud particle sizes by about 20% and consequently inhibited warm rain processes

Urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine concentrations after frying of bacon, a pilot study

Cooking fumes contain compounds that may give rise to oxidative stress and mutations when inhaled. The aim of this study was to evaluate if cooking fumes from frying of bacon induce oxidative stress by measurement of urinary 8-oxo-7,8-dihydro-2 deoxyguanosine, a marker of oxidatively damaged DNA. Three non-smoking women fried bacon for 3 h. Urine samples were taken as early morning void at the sam