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Introduction: Exposure to high acoustic noise levels generated during 7 Tesla (T) magnetic resonance imaging (MRI) may affect auditory function. To better understand these effects, this study examines how such noise exposure influences outer hair cell function in healthy adults, with a focus on the efficiency of a dual hearing protection method. Methods: In this within-subjects longitudinal study,
Growth and immune development—fundamental parts of any organism's ontogeny—depend critically on nutrient availability, particularly on essential amino acids that support protein synthesis and physiological processes. However, environmental variation can reduce prey diversity and nutrient quality, producing suboptimal diets that lack essential amino acids, potentially constraining development. In t
The Bcl-2 family of proteins governs mitochondrial outer membrane (MOM) permeabilization, a critical step in apoptosis that is dysfunctional in many cancers. Although cellular studies have long implicated direct interactions between the pore-forming apoptotic Bax protein and its opponent, the antiapoptotic Bcl-2 protein in apoptosis regulation, the underlying basic principles behind this control r
More than six decades ago, Aníbal Pinto Santa Cruz (1959) published his pivotal work, Chile, a case of frustrated development. Almost 65 years later, this concept has been reborn under the massive protests and social unrest of 2019, the COVID pandemic, and the new lithium cycle. Chile, the former “Latin American Miracle,” has become an unstable and troublesome state, not particularly different fro
Molecular oxygen activation at single transition metal atom sites is critical for catalysis but remains challenging to control. Here we investigate a manganese–cobalt bi-metallic coordination network on graphene, where Co(i) atoms are tetracoordinated by nitrogen. Combining density functional theory with in situ infrared-visible sum-frequency generation and ambient-pressure X-ray photoelectron spe
This master’s thesis investigates tool bending in solid carbide end mills during shoulder milling of CK45 steel, SS 1.4923, SS 316L, and TiAl6V4. Five different tool designs were tested to evaluate the influence of cutting speed and feed rate on tool deflection, surface quality, and machining stability. The results show that feed rate has a stronger effect on tool bending than cutting speed. High
Denna studie undersöker konflikten i Taranto, en stad i södra Italien som sedan 1960 talet har hyst ett av Europas största stålverk, Ilva. Under årtiondenas lopp har Ilva omformat Tarantos socioekonomiska och miljömässiga landskap och orsakat allvarlig förorening, som epidemiologiska studier har kopplat till överdödlighet och ökad sjuklighet. Denna kris har lett till en konflikt som också har utkäThis study examines the conflict in Taranto, a city in Southern Italy that has hosted one of Europe’s largest steel plants, Ilva, since the 1960s. Over the decades, Ilva has reshaped Taranto’s socioeconomic and environmental landscape, causing severe pollution that epidemiological studies have linked to excess mortality and morbidity. This crisis has led to a conflict fought also through legal mea
Objective: Degenerative orthopedic diseases (DODs) such as osteoporosis, osteoarthritis, spondylosis, spinal stenosis, and disc herniation are common disorders. Both common and rare genetic risk factors may contribute to DODs, but few large-scale whole-exome sequencing studies elucidating the contribution of rare variations to DODs have been published. The updated version of the Astra Zeneca porta
The molecular mechanisms governing internal fluctuations in intrinsically disordered protein (IDP) assemblies are crucial to the stability and dynamics of both regulated and aberrant toxic cellular aggregates, but remain poorly understood. By comprehensively combining high-resolution quasi-elastic neutron scattering with all-atom molecular dynamics simulations, we probe the motions of β-casein, a
DEBATT. I tider av hög arbetslöshet och ökade matpriser riskerar många familjer att drabbas av ekonomisk utsatthet. Men barnfattigdomen i Sverige är kraftigt ojämnt fördelad. Vår ESO-rapport visar att risken att växa upp i fattigdom varierar med föräldrarnas arbetsmarknadsanknytning, familjens storlek och om barnet lever med en ensamstående förälder. Skillnaderna är stora mellan barn till utrikesf
Cryo-scanning electron microscopy (CryoSEM) permits the preparation and detailed imaging of bulky samples while keeping them in a hydrated state. For plant biology, cryofractures give information on cell ultrastructure and tissue organisation within a much larger context that is the whole organ or organism. To date, a method to locate fluorescence reporters on the cryofracture has not been reporte
Construction robot prototype for onsite work. Consists of an ABB IRB4600 mounted on a spindle crane chassi for mobility. Housed in a container for weather protection and logistics.
”Hur kan det europeiska storstadstornet rädda staden?” Ungefär så, och sett i motsats till den anglosaxiska skyskrapan, kan det projekt som genomsyrar den här boken formuleras..."
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th
