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A longitudinal study of sexual functioning in women referred for colposcopy: a 2-year follow up.

Objective To elucidate psychosexual problems in women referred for colposcopy after an abnormal cervical smear and a 6-month and 2-year follow up. Design Prospective study. Setting Department of Gynaecology, Malmö University Hospital, Sweden. Population One hundred consecutive women referred for colposcopy for the first time subsequent to receiving notification of an abnormal cervical smear. M

MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover

Although it has been shown that aggrecanases are involved in aggrecan degradation, the role of MMP (matrix metalloproteinase) aggrecanolysis is less well studied. To investigate MMP proteolysis of human aggrecan, in the present study we used neoepitope antibodies against MMP cleavage sites and Western blot analysis to identify MMP-generated fragments in normal and OA (osteoarthritis/osteoarthritic

Added diagnostic utility of CT perfusion and CT angiography in acute ischemic stroke. Evaluation of three different patient categories

Patients with a clinical picture of acute ischemic stroke are a heterogeneous group. The aim of this study was to evaluate the added utility of CT perfusion (CTP) and CT angiography (CTA) in the workup of three different categories of acute ischemic stroke patients. Fifty patients (61 +/- 05 years old) were included in this retrospective analysis. Twenty-nine patients had transient ischemic attack

Treatment of oral mucositis pain following radiation therapy for head-and-neck cancer using a bioadhesive barrier-forming lipid solution

CAM2028, a vehicle that forms a bioadhesive lipid barrier when applied to the oral mucosa, was developed as a carrier system for local delivery of benzydamine, an NSAID used for pain relief in oral mucositis. This trial compared the analgesic effect of CAM2028 plus benzydamine (CAM2028-benzydamine) with unmedicated CAM2028 (CAM2028-control) for the treatment of oral mucositis in patients with head

Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow

Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tono

Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source

The Compact Light Source is a miniature synchrotron producing X-rays at the interaction point of a counter-propagating laser pulse and electron bunch through the process of inverse Compton scattering. The small transverse size of the luminous region yields a highly coherent beam with an angular divergence of a few milliradians. The intrinsic monochromaticity and coherence of the produced X-rays ca

A Socio-technical toolbox for business systems analysis and design

This paper provides an overview of a socio-technical toolbox (STT) based on a combination of methods from a number of contemporary socio-technical (ST) methodologies. The STT supports a pragmatic ST approach to organizational change practice and job redesign. It has been developed and used in practice in many different types of organizations over a period of many years. The use in practice of STT

Predictive Control of Diabetic Glycemia

Diabetes Mellitus is a chronic disease, where the blood glucose concentration of the patient is elevated. This is either because of missing insulin production due to failure of the β-cells in the pancreas (Type 1) or because of reduced sensitivity of the cells in the body to insulin (Type 2). The therapy for Type 1 diabetic patients usually consists of insulin injections to substitute for the miss

Impact of glucose dosing regimens on modeling of glucose tolerance and β-cell function by intravenous glucose tolerance test in diet-induced obese mice.

Insulin sensitivity declines in overweight and obese individuals and, under normal conditions, insulin secretion adaptively increases which in healthy non-diabetic subjects maintains normal glycemia. This adaptation is best described by the disposition index derived from modeling of insulin and glucose data from an intravenous glucose tolerance testing (IVGTT). One caveat of the IVGTT is that basi

Human footsteps induced floor vibration.

The generation of the impact sound by the act of the human walk involves two factors, the characters of the footfall and the shape of the induced floor deflection. The footfall noise is created by the impact excitation and the characters of the footfall depend on the foot-ware: the heels and the frequencies of the footfall. The shape of the floor deflection depends rather on the geometrical walkin

Automated Decision Support for Bone Scintigraphy

A quantitative analysis of metastatic bone involvement can be an important prognostic indicator of survival or a tool in monitoring treatment response in patients with cancer The purpose of this study was to develop a completely automated decision support system for whole-body bone scans using image analysis and artificial neural networks. The study population consisted of 795 whole-body bone scan

Do male ornaments signal immunity in the common yellowthroat?

Male ornaments may advertise genetic benefits to females choosing mates. These benefits may come in the form of genes for resistance to parasites and disease. Thus, females that prefer more ornamented males as mates may receive genes for enhanced immune system function for their offspring. The common yellowthroat (Geothlypis trichas) is the only species to date in which a male plumage ornament (si

Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study

Background: The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN). Methods: The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51

Mentoring Radiology Residents in Clinical and Translational Research.

To be an effective mentor at any level is always a challenge and requires a dedication to teaching and mentorship and being prepared to devote a significant proportion of one's time. But if you are open-minded and deeply care for your mentee, you have the opportunity to be a successful mentor. This presentation is based on personal experience of mentoring radiology residents, doctoral students, an