α-Galactosidase (EC 3.2.1.22) and β-mannosidase (EC 3.2.1.25) participate in the hydrolysis of complex plant saccharides such as galacto(gluco)mannans. Here we report on the cloning and characterization of genes encoding an α-galactosidase (AglC) and a β-mannosidase (MndA) from Aspergillus niger. The aglC and mndA genes code for 747 and 931 amino acids, respectively, including the eukaryotic signa

BACKGROUND: Rotational thromboelastography (ROTEG) has been proposed as a monitoring tool that can be used to monitor treatment of hemophilia with recombinant factor VIIa (rFVIIa). In these studies special non-standard reagents were used as activators of the coagulation. The aim of this study was to evaluate if standard ROTEG analysis could be used for monitoring of effects of recombinant factor V

Antithyroid treatment effectively restores euthyroidism in patients with Graves' hyperthyroidism. After a few months of treatment, patients are clinically euthyroid with normal levels of thyroid hormones, but in many patients TSH levels remain suppressed. We postulated that TSH receptor autoantibodies could directly suppress TSH secretion, independently from thyroid hormone levels, via binding to

Clinical trials involving intrastriatal transplants of human embryonic mesencephalic tissue have provided proof-of-principle that nigral dopamine (DA) neurons can survive and functionally integrate into the host neural circuitry. However, the degree of graft-induced symptomatic relief differs significantly between the patients. This variability has led to investigations aimed at identifying factor

Popular Abstract in Swedish Doften av blommor och mat förnimmer vi med näsan, vilken är en finurlig gassensor som även känner av mindre trevliga lukter från exempelvis rök och avgaser. Våra ögon ser färger och former hos föremål genom att detektera ljus som har reflekterats, brutits, spridits eller delvis absorberats i vår omgivning. Denna avhandling beskriver i någon mening en sorts konstgjorda Laser spectroscopic techniques for gas analysis under various influences of light scattering are explored in a wide spectral range from the ultraviolet to the infrared. The techniques rely on spectrally narrow-band light sources that are used in differential optical absorption measurements. A DIfferential Absorption Light detection and ranging (DIAL)application for the monitoring of atomic gaseou

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. However, identifying genes controlling complex diseases such as RA has proven extremely difficult and to date only a fe

Syftet med rapporten är att presentera en riskbaserad metod för brandteknisk dimensionering genom beräkning samt att exemplifiera hur denna kan användas. Det finns olika metoder att dimensionera en byggnad så att egenskapskraven angående brandsäkerhet följs. En av dem är att följa de råd som finns i byggreglerna och därigenom dimensionera brandsäkerheten genom så kallad förenklad dimensionering. O

The effect of moderate hypoglycemia (p-glucose, 2.0 +/- 0.3 mmol/L; mean +/- SD) on regional cerebral blood flow (rCBF) was studied in a group of 10 healthy, right-handed men (aged 23 to 28 years) using an intravenous xenon 133 single photon emission computed tomography technique (SPECT). After 10 minutes of hypoglycemia, global CBF had increased to 46.3 +/- 9.6 mL/100 g/min compared with the init

In the study of economic-geographic structures, the shifting focus from the national state to the city and its region has highlighted the lack of reliable interurban data sets. The abundance of usable data sets on international structures and ?ows has no counterpart when studying interurban relations, which makes it hard to draw any extensive conclusions regarding the structure of world city netwo

This report has a two-fold objective. -To identify the changing risk management needs in the private and public sectors and the corresponding needs for development of risk analysis methods and related practices. -To list examples of projects where Nordic co-operation between industry, authorities and universities can be effective for increasing the contribution of risk management to industrial gro

High-spin states in the neutron-deficient isotope Cd-104 were populated using the Cr-50(Ni-58,4p)Cd-104 reaction at a beam energy of 250 MeV The level scheme has been extended using triple gamma-ray coincidences to a spin of 29h and an excitation energy of 18.2 MeV. Several collective structures involving the excitation of h(11/2) neutrons have been observed to spins approaching 30h. The high-spin