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Incorporating Forecasts of Rainfall in Two Hydrologic Models Used for Medium-Range Streamflow Forecasting

This study reports on the performance of two medium-range streamflow forecast models: (1) a multilayer feed-forward artificial neural network; and (2) a distributed hydrologic model. Quantitative precipitation forecasts were used as input to both models. The Furnas Reservoir on the Rio Grande River was selected as a case study, primarily because of the availability of quantitative precipitation fo

High resolution sparse estimation of exponentially decaying signals

We consider the problem of sparse modeling of a signal consisting of an unknown number of exponentially decaying sinusoids. Since such signals are not sparse in an oversampled Fourier matrix, earlier approaches typically exploit large dictionary matrices that include not only a finely spaced frequency grid but also a grid over the considered damping factors. The resulting dictionary is often very

Swedish health care providers' experience and knowledge of female genital cutting.

We sought to evaluate the experiences and knowledge of health care providers in Sweden regarding female genital cutting (FGC) as a health issue. Questionnaires (n = 2,707) were sent to providers in four major cities in Sweden and evaluated by means of descriptive statistics. Twenty-eight percent (n = 769/2,707) responded, of whom 60% had seen such patients. Seven providers, including 2 pediatricia

Geometric scaling and QCD dynamics in DIS

DIS data from HERA show a striking regularity as sigma(gamma*p) is a function of the ratio tau = Q(2)/Q(s)(2)(x) only. The scaling function shows a break at 7 t, which has been taken as an indication for saturation. However, besides saturation also the transition between dominance of k(perpendicular to)-ordered (DGLAP) and k(perpendicular to)-non-ordered (BFKL) evolution contributes to a break aro

Mass Spectrometry Analysis of a Protein Kinase CK2 beta Subunit Interactome Isolated from Mouse Brain by Affinity Chromatography.

CK2, an acronym derived from the misnomer "casein kinase 2", denotes a ubiquitous and extremely pleiotropic Ser/Thr protein kinase, the holoenzyme of which is composed of two catalytic (alpha and/or alpha') and two noncatalytic beta subunits acting as a docking platform and the multifarious functions of which are still incompletely understood. By combining affinity chromatography and mass spectrom

The structure and function of the vegetative mycelium of ectomycorrhizal plants .4. Qualitative-analysis of carbohydrate contents of mycelium interconnecting host plants

Plants of Pinus spp. were grown in observation chambers with the mycorrhizal fungi Suillus bovinus, Pisolithus tinctorius or Paxillus involutus. After interconnecting mycelial systems had developed between plants, individual hosts in some chambers of each species were fed with 14CO2. Mycelia from radioactively labelled and unlabelled chambers were harvested and their carbohydrates were extracted,

Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography.

There is an overlap regarding Pittsburgh compound B (PIB) retention in patients clinically diagnosed as Alzheimer's disease (AD) and non-AD dementia. The aim of the present study was to investigate whether there are any differences between PIB-positive and PIB-negative patients in a mixed cohort of patients with neurodegenerative dementia of mild severity regarding neuropsychological test performa

p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis.

We recently reported that p38 MAPK regulates TNF-induced endothelial apoptosis via phosphorylation and downregulation of Bcl-xL. Here, we describe that such apoptosis includes p38 NIAPK-mediated, protein phosphatase 2A (PP2A)-dependent, downregulation of the MEK-ERK pathway. Inhibition of PP2A with fostriecin or calyculin A significantly increased MEK phosphorylation, as did exposure to the p38 MA

Radiative lifetimes of 6sns S-3(1) and 6snd D-3(1) excited states of HgI

Natural radiative lifetimes have been measured along the 6sns S-3(1) (n=7-10) and 6snd D-3(1) (n=6-11) Rydberg series of neutral mercury using time-resolved laser-induced fluorescence spectroscopy in a laser-produced mercury plasma. The states of Hg I investigated in the present work were populated from the ground state by a stepwise excitation process. Relativistic Hartree-Fock calculations, incl

Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-beta knock-out mice.

BACKGROUND: CpG oligodeoxynucleotides (CpG-ODN) are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore, type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-beta in the immunomodulatory effects of CpG-ODN is not known. OBJECTIVE: Here, we aimed to elucidate the role of IFN-beta in the anti-allergi

Temperature adaptation of soil bacterial communities along an Antarctic climate gradient: predicting responses to climate warming

Soil microorganisms, the central drivers of terrestrial Antarctic ecosystems, are being confronted with increasing temperatures as parts of the continent experience considerable warming. Here we determined short-term temperature dependencies of Antarctic soil bacterial community growth rates, using the leucine incorporation technique, in order to predict future changes in temperature sensitivity o

Conflict of interest between sexes over cooperation: a supergame on egg carrying and mating in a coreid bug

In the golden egg bug (Phyllomorpha laciniata Vill. Heteroptera: Coreidae) females lay eggs on the backs of conspecifics, often on courting males. Although the bugs do not provide care to the eggs, this decreases the risk of egg predation. As an effect males carry many eggs which are not their own. The male and female interests are in conflict; females need to find an oviposition site, and male fi

New antimicrobial cystatin C-based peptide active against gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus and multiresistant coagulase-negative staphylococci

We describe the synthesis and antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(Nalpha-benzyloxycarbonyl-arginyl-leucylamido-1-[(E)-cinnamoylamido]-3-methylbutane, structurally based upon the inhibitory centre of the human cysteine protease inhibitor, cystatin C. The derivative, here called Cystapep 1, displayed antibacterial activity against several clinically importa

Primary nonoperative treatment of moderately displaced two-part fractures of the radial head

Background: Moderately displaced two-fragment fractures of the radial head have been treated predominantly nonoperatively. Recently, however, open reduction and internal fixation has gradually gained interest, without clear evidence that initial nonoperative treatment leads to an unfavorable outcome. As a consequence, the purpose of the present study was to evaluate the long-term outcome after the

CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18

Molecular mimicry of chemokine ligands has been described for several pathogens. Toxoplasma gondii produces a protein, cyclophilin-18 (C-18), which binds to the human immunodeficiency virus (HIV) co-receptor CCR5 and inhibits fusion and infection of T cells and macrophages by R5 viruses but not by X4 viruses. We recently identified structural determinants of C-18 required for anti-HIV activity (Ya

The fibronectin-binding integrins alpha 5 beta 1 and alpha v beta 3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

We have studied the formation of different types of cell matrix adhesions in cells that bind to fibronectin via either alpha5beta1 or alphavbeta3. In both cases, cell adhesion to fibronectin leads to a rapid decrease in RhoA activity. However, alpha5beta1 but not alphavbeta3 supports high levels of RhoA activity at later stages of cell spreading, which are associated with a translocation of focal

Differential effects of estrogen on DNA synthesis in human periodontal ligament and breast cancer cells.

BACKGROUND: It is important to clarify the biological function of the female sex hormones estrogen and progesterone in periodontal ligament cells, as these hormones may affect periodontal health. We have previously shown that human periodontal ligament cells express estrogen receptor beta (ERbeta) but not ERalpha, whereas human breast cancer cells (MCF7) express both ERalpha and ERbeta. Data on pr