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Prophylaxis and treatment of HIV-1 infection in pregnancy: Swedish recommendations 2013

Prophylaxis and treatment with antiretroviral drugs and elective caesarean section delivery have resulted in very low mother-to-child transmission of HIV during recent years. Updated general treatment guidelines and increasing knowledge about mother-to-child transmission have necessitated regular revisions of the recommendations for the prophylaxis and treatment of HIV-1 infection in pregnancy. Th

Phase separation in binary eye lens protein mixtures

Liquid-liquid phase separation occurs in young mammalian eye lenses and in concentrated solutions of isolated eye lens proteins, and has been linked to some forms of cataract. Here we study theoretically the protein compositions and cloud temperatures of two separated equilibrium phases that form out of concentrated mixtures of model proteins, chosen to have properties similar to those which repro

Guess the impact of Ips typographus – An ecosystem modelling approach for simulating bark beetle outbreaks

Spruce bark beetle outbreaks are common in Norway spruce forests following windstorm damage, due to ample availability of brood material. The realization of an outbreak depends on factors regulating the Ips typographus population dynamics, such as weather conditions and salvage cutting. In this study, we take an ecosystem modelling approach to analyse the influence of multiple environmental factor

Characteristics of airborne gold aggregates generated by spark discharge and high temperature evaporation furnace: Mass-mobility relationship and surface area

The properties of gas-borne aggregates are important in nano-technology and for potential health effects. Gold aggregates from three generators (one commercial and one custom built spark discharge generator and one high-temperature furnace) have been characterized. The aggregate surface areas were determined using five approaches - based on aggregation theory and/or measured aggregate properties.

Sociala utredningar om brottsutsatta barn. Målgrupp, handläggning och insatser. Delrapport 3 i utvärderingen av nationell försöksverksamhet med barnahus 2006-2007.

Barnahus är en ny modell för samverkan mellan myndigheter kring som utsatts för brott. Tanken är att barnen ska bli omhändertagna i en barnvänlig miljö där alla nödvändiga utredningar kan genomföras. Socialtjänsten är en av de berörda myndigheterna, och har ett särskilt ansvar för att dessa barn får det skydd eller stöd de behöver. I denna bok undersöks och jämförs socialtjänstens utredningar om

A new global fit of the L(i)(r) at next-to-next-to-leading order in Chiral Perturbation Theory

Abstract in Undeterminednew fit is done to obtain numerical values for the order p(4) low-energy-constants L(i)(r) in Chiral Perturbation Theory. This includes both new data and new calculated observables. We take into account masses, decay constants, K(l4), pi pi and pi K scattering lengths and slopes and the slope of the pion scalar formfactor. We compare in detail where the changes w.r.t. the 1

In-group ratings are affected by who asks and how: interactive effects of experimenter group-membership and response format.

In three experiments, participants rated how well a number of adjectives described their in-group (e.g. kind-hearted, helpful, intelligent, efficient, etc.). In Experiment 1, females were found to rate their ingroup (females) more favorably when reporting verbally to female (rather than male) experimenters. This finding was further explored in two subsequent experiments where response format (writ

Influence of feed and water on the stable isotopic composition of dairy milk

Traceability of dairy products is an important issue for the dairy industry. Empirical studies have demonstrated the utility of stable isotope measurements on milk for verification of origin. However, various drivers influence the isotopic composition of a food stuff, such as rainfall levels or food supplements. Relationships between the isotopic composition (δ2H, δ18O, δ13C and δ15N) of milk fatt

The Concept of Norms in Sociology of Law

The aim of this article is to propose a method for creating a more coherent concept of norms – and to deliver a tentative and open suggestion on how to define norms in a way that might fit into the context of Sociology of Law (further on shortened, SoL). The idea is that the norm concept can be chiselled out through ontological analysis, and that this analysis can be conducted in a way that allow

Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.

We compared results obtained with the Nanosphere Verigene® System, a novel point-of-care (POC) genetic test capable of analysing 11 CYP2C19 variants within 3 hours, to an established, validated genotyping method (Affymetrix™ DMET+; reference assay) for identifying extensive and reduced metabolisers of clopidogrel. Based on genotyping, patients (N=82) with stable coronary artery disease on clopidog

High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors

Background The existence of multiple subsets of chronic lymphocytic leukemia expressing 'stereotyped' B-cell receptors implies the involvement of antigen(s) in leukemogenesis. Studies also indicate that 'stereotypy' may influence the clinical course of patients with chronic lymphocytic leukemia, for example, in subsets with stereotyped IGHV3-21 and IGHV4-34 B-cell receptors; however, little is kno

Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation

Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. Studies of vascular involvement in asthma have main

Association and electrostatic steering of alpha-lactalbumin-lysozyme heterodimers

The salt and pH dependent association of hen egg white lysozyme with alpha-lactalbumin whey proteins has been studied using molecular level Monte Carlo simulations. A highly uneven charge distribution of alpha-lactalbumin leads to strongly ordered heterodimers that may facilitate the formation of structured, mesoscopic aggregates. This electrostatic steering gives rise to 80% alignment at 5 mM 1:1

Use of non-conventional yeast improves the wine aroma profile of Ribolla Gialla

Consumer wine preferences are changing rapidly towards exotic flavours and tastes. In this work, we tested five non-conventional yeast strains for their potential to improve Ribolla Gialla wine quality. These strains were previously selected from numerous yeasts interesting as food production candidates. Sequential fermentation of Ribolla Gialla grape juice with the addition of the Saccharomyces c

Comparing aerodynamic efficiency in birds and bats suggests better flight performance in birds.

Flight is one of the energetically most costly activities in the animal kingdom, suggesting that natural selection should work to optimize flight performance. The similar size and flight speed of birds and bats may therefore suggest convergent aerodynamic performance; alternatively, flight performance could be restricted by phylogenetic constraints. We test which of these scenarios fit to two meas