Introduction: Previous studies have shown that the injection of adipose tissue–derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis. Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD. Methods: 27 male, 12-

A new method of model reduction is introduced based on the differentiation of polynomials. The reciprocals of the numerator and denominator polynomials of the high-order transfer function are differentiated suitably many times to yield the coefficients of the reduced order transfer function. An error analysis shows the accuracy of the method, and an eighth-order example illustrates it. The method

A new approach to the constrained function optimization problem is presented. It is shown that the ordinary Lagrange multiplier method and the penalty function method may be generalized and combined, and the new concept ofmultiplier function is introduced. The problem may then be converted into an unconstrained well-conditioned optimization problem. Methods for numerical solution are discussed, an

PURPOSE OF REVIEW: The clinical and inflammatory heterogeneity in asthma constitutes a major challenge for improved treatment. This review describes the nature of the inflammatory complexity and how it can be decoded to yield improved disease understanding and personalized treatment. The focus is on the difficult task of revealing the immunological complexity as it occurs inside diseased patient t

Background: To examine risk of severe perineal trauma among nulliparous women and those undergoing vaginal birth after cesarean delivery (VBAC). Methods: This is a population-based cohort study of all births to women with their two first consecutive singleton pregnancies in Stockholm-Gotland Sweden between 2008 and 2014. Risk of severe perineal trauma was compared between nulliparous women and tho

PURPOSE OF REVIEW: In the past decades, cysteinyl leukotrienes (CysLTs) and prostaglandin D2 have been recognized as key mediators of asthma and comorbid conditions for their potent broncho-active and proinflammatory properties. However, both the development and initial positioning of small molecules targeting these lipid mediators [i.e., leukotriene-synthesis inhibitors, CysLT-antagonists, and ch

Children who have parents with any kind of illness may become young carers who take a responsibility not expected of children for household tasks, or personal or emotional care for parents and siblings. So far, little is known about children in Sweden who are at risk of becoming young carers. The aim of this article is therefore to explore the extent and impact of children's caring activities as r

In aqueous solution of 1,1'-diethyl-2,2'-carbocyanine J-aggregate, the exciton self-trapped (EST) state is usually expected to be negligible. However, in this work, by measuring transient absorption spectroscopy under a variety of excitation fluences, the EST state was found to be formed via coherent exciton-exciton annihilation (EEA), when the excitation fluence was high enough. With the existenc