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The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m

Carbon capture and storage (CCS) is considered by some to be a critical climate change mitigation technology, and a key element in efforts to limit the global temperature increases in line with the goals of the Paris Agreement. Implementation of CCS in mitigation scenarios assumes that it provides cost-effective emission reductions, and/or can achieve negative emissions when combined with bioenerg

Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational stud

Hypothesis: The oil phase controls the persistence length and aqueous channel diameter of reverse wormlike micelles (RWLMs), specifically by tuning the cohesive energy density of alkanes. Experiments: We explore the influence of alkanes with varying chain lengths on the rheological properties, structural parameters, and morphology of RWLMs. To establish a link between the solvent characteristics a

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This is a multicentric retrospective cohort study of patients treated with endoscopy or surgery for ampullary CoGNET. A literature review of ampullary CoGNET was also performed. Fifteen patients were

Assessment of psychological constructs, such as the Big Five personality traits, has predominantly relied on standardized rating scales. While these scales have advantages, we propose that descriptive word-based responses analyzed with natural language processing (NLP) offer a promising alternative for assessing personality traits. We asked participants (N = 663) to describe either their own perso

Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of out

Network Function Virtualization (NFV) has shifted communication networks towards more adaptable software solutions, but this transition raises new security concerns, particularly in public cloud deployments. While Intel’s Software Guard Extensions (SGX) offers a potential remedy, it requires complex application adaptations. This paper investigates AMD’s Secure Encrypted Virtualization (SEV) as an

Neural radiance fields (NeRFs) have gained popularity in the autonomous driving (AD) community. Recent meth-ods show NeRFs' potential for closed-loop simulation, en-abling testing of AD systems, and as an advanced training data augmentation technique. However, existing meth-ods often require long training times, dense semantic su-pervision, or lack generalizability. This, in turn, hinders the appl

AimDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.MethodsAntiDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an

People form part of the biosphere - the biosphere being the whole intertwined network of life on Earth. While there is convergence on the need for societal change for just sustainability and a healthy biosphere, the pathways to achieve these transformations remain relatively unclear. Through legal interpretation, conceptual and thematic analysis of academic and grey literature, we seek to answer t

As the support for households which bring up an infant is increasing recently, there is a growing concerning about the consistency of such support with applicable support system and a greater interest in the change of demands for infant-rearing support policy for those households. Therefore, systemization is necessary to identify various supports for infant-rearing families quickly and to provide

Over the past years, the natural environment has increasingly become instrumental in peace policies and the focus of study in peace and conflict research. Concurrently, there is mounting global recognition that nature contributes to peoples wellbeing in manifold ways and that incorporating diverse values of nature in policymaking is paramount for sustainable development. At the nexus of current de

Previous research has established that the brain uses episodic memories to make continuous predictions about the world and that prediction errors, so the mismatch between generated predictions and reality, can lead to memory updating. However, it remains unclear whether prediction errors can stimulate updating in memories for naturalistic conversations. Participants encoded naturalistic dialogues,

Background: As the deadline for the Sustainable Development Goals approaches, financial protection in Cambodia remains inadequate, especially for nonpoor informal workers lacking formal social health protection coverage or access to other prepayment schemes. This exposes them to high out-of-pocket health expenditures (OOPE) and related financial hardship. To better understand the drivers behind th

In 2022, the Yangtze River Basin in China experienced an unprecedented extreme drought, induced by high temperatures and precipitation deficits. Accurate monitoring of such extreme drought events is vitally significant for disaster mitigation under global warming. This study evaluated the effectiveness of two satellite-based precipitation products: the latest Integrated Multi-satellitE Retrievals

Aim of the workshop: We invite colleagues to share experiences on cross-fertilization of art and social work research and to discuss how research-based art can serve as a catalyst for social change. Also, the workshop will give hands on knowledge on how to work with the method “deepened film talks”. Background: In a research project focusing moral stress and moral agency in social work, concrete s

Background and aims: Good Selenium (Se) status predicts favorable prognoses for various diseases and a reduced overall mortality. The primary objective of the study was to determine whether Selenium status, i.e. Selenoprotein P (SeP) levels, is associated with risk of 90-day mortality in elderly patients with acute dyspnea at the Emergency Department (ED). Methods and results: Patients presenting