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Background: Day surgery is increasing, and safe and effective logistics are sought. One part of the in-theatre logistics commonly discussed is whether surgical scrub and sterile covering should be done before or after induction of anaesthesia. The aim of the present study was to compare the impact of surgical scrub and sterile covering before vs. after the induction of anaesthesia in male patients

Rationale, aims and objectives: Day surgery is evolving, with a majority of recoveries occurring at home. There is, in parallel, an evolution in telemedical technology. The aim of the present project was to identify patients’ willingness to use predefined follow-up techniques and to clinically test preferred techniques at home using a two-step study.┅. Methods: In Part I, a paper-based questionnai

Proteins constitute a major component of living cells and are essential to their function. Sometimes proteins misfold or aggregate in abnormal ways, which can give rise to diseases. Amyloids are a special type of highly ordered protein aggregates made of long intermolecular beta-sheets stacked into fibrils. Formation of amyloids is associated with many diseases, especially diseases related to neur

The chemical composition of foraminiferal calcite is widely used for studying past environmental conditions and biogeochemistry. However, high rates of microbial organic matter degradation and abundant dissolved metal sources in sediments and pore waters may impede the application of foraminifera-based proxies due to formation of secondary carbonates or other authigenic minerals on and/or inside o

Human glial progenitor cells (hGPCs) are promising cellular substrates to explore for the in situ production of new neurons for brain repair. Proof of concept for direct neuronal reprogramming of glial progenitors has been obtained in mouse models in vivo, but conversion using human cells has not yet been demonstrated. Such studies have been difficult to perform since hGPCs are born late during hu

I papret argumenteras för behovet av att förstå doktorandhandledning som kontextberoende – som en relationell och situationell social praktik. En central uppgift för handledaren är att reflektera över, och problematisera, vilka olika subjektspositioner som är verksamma i samspelet mellan handledare och doktorand, och hur dessa påverkar handledningen. Detta eftersom olika subjektspositioner ofrånko

Objective: In this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in the PanCareSurFup study. Methods: Eight data providers (France, Hungary, Italy (two cohorts), the Netherlands, Slovenia, Switzerland and the UK) participating in PanCareSurFup ascertained and validated symptom

Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 sa

Summary: The existing information supports the use of this material as described in this safety assessment. 2-Phenylpropionaldehyde was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data on read-across analogs 3-phenylbutanal (CAS # 16251-77-7)

The aggregation of the 11 residue long NACore peptide segment of α-synuclein (68-GAVVTGVTAVA-78) has been investigated using a combination of cryogenic transmission electron microscopy (cryo-TEM), small- and wide-angle X-ray scattering, and spectroscopy techniques. The aqueous peptide solubility is pH dependent, and aggregation was triggered by a pH quench from pH 11.3 to approximately pH 8 or 6,

Combustion of fuel in diesel engines emits substances harmful to the environment such as soot. These emissions can be reduced by either in-cylinder treatments or after-treatments. One of the common in-cylinder treatments is multiple-injection, which divides a single fuel injection to multiple smaller injections. There are many open questions on the physical processes of the ignition, combustion an

Background: Although effective return-to-work (RTW) interventions are not widely available for individuals with common mental disorders on sick leave, there is potential for transforming such interventions into a digital solution in an effort to make them more widely available. However, little is currently known about the viewpoints of different stakeholder groups, which are critical for successfu

Arctic tundra is a globally important store for carbon (C). However, there is a lack of reference sites characterising C exchange dynamics across annual cycles. Based on the Greenland Ecosystem Monitoring (GEM) programme, here we present 9-11 years of flux and ecosystem data across the period 2008-2018 from two wetland sites in Greenland: Zackenberg (74°N) and Kobbefjord (64°N). The Zackenberg fen

Erlotinib inhibits epithelial growth factor receptor (EGFR) kinase activity and is used to treat non-small cell lung cancer (NSCLC). Despite its high efficacy, recurrence can occur in patients who become resistant to the drug. To address the underlying mechanism of Erlotinib resistance, we investigated additional mechanisms related to mode-of-drug-action, by multiple protein-binding interactions,

OBJECTIVE The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1, 2011, and December 31, 2015. All neurosurgical ce