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The aim of this study was to investigate the microvascular responses in the skin, to local heat, iontophoretically administered acetylcholine and to sodium nitroprusside in relation to cardiovascular damage in patients with systemic lupus erythematosus (SLE) and matched controls. We also wanted to examine if the ongoing medication in SLE patients influenced this vascular response. We investigated
Objectives. To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation. Methods. We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM). Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs. A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was ap
We quantified the semantic content in adolescents’ descriptions of positive and negative life events and studied how these descriptions are related to the assessment Subjective Well-Being (SWB) at two points in time. The semantic content of the descriptions was quantified by Latent Semantic Analysis (LSA). LSA is a computational method based on algorithms stemming from computational linguistics, w
There exists compelling experimental evidence in numerous systems for logarithmically slow time evolution, yet its full theoretical understanding remains elusive. We here introduce and study a generic transition process in complex systems, based on nonrenewal, aging waiting times. Each state n of the system follows a local clock initiated at t = 0. The random time tau between clock ticks follows t
β-Mannanases are involved in the conversion and modification of mannan-based saccharides. Using a retaining mechanism, they can, in addition to hydrolysis, also potentially perform transglycosylation reactions, synthesizing new glyco-conjugates. Transglycosylation has been reported for β-mannanases in GH5 and GH113. However, although they share the same fold and catalytic mechanism, there may be d
A detailed stratigraphical, palaeoecological and geomorphological reconstruction of a fjord head on South Georgia (Husvik, Stromness Bay) is presented. Six sites were chosen to reconstruct the lithostratigraphy of the area by means of coring. A maximum depth of 11m was attained and the sediments encountered vary from coarse gravel over sands to fine silts with, in some cases, intercalated peat lay
Objective. To investigate gender differences in the association between self-rated health (SRH) and impaired glucose tolerance (IGT) in subjects unaware of their glucose tolerance. Design. A cross-sectional population-based study. Setting. The two municipalities of Vara and Skovde in south-western Sweden. Subjects. A total of 2502 participants (1301 women and 1201 men), aged 30-75, were randomly s
Purpose The purpose is to outline the conditions for a new service system in healthcare, which will be able to match the available capacity in and between healthcare units in order to match the need of care for the patients. Methodology By drawing on statements from patients, experiences from similar services (a literature review), empirical research into the effects of the reforms on free choice
In this study, the potential of a chitosan-agarose-gelatin (CAG) cryogel scaffold for the repair of subchondral cartilage defects was explored in female New Zealand white rabbits. Custom-made CAG cryogel scaffold was implanted in a surgically created subchondral defect (diameter of 4 mm, depth of 4 mm) in knee joint of rabbit. The repair of the subchondral defect was evaluated at regular time inte
We consider a class of pseudodifferential evolution equations of the form u(t) + (n(u) + Lu)(x) = 0, in which L is a linear smoothing operator and n is at least quadratic near the origin; this class includes in particular the Whitham equation. A family of solitary-wave solutions is found using a constrained minimization principle and concentration-compactness methods for noncoercive functionals. T
A series of polystyrene-clay nanocomposites, based on two natural clay types (Na-Montmorillonite and Hectorite) and two synthetic clays (Laponite and Li- Fluorohectorite), were prepared via in situ intercalative polymerization after surface modification with an organic ammonium cation (CTAB). The structural characteristics of the organically modified clays as well as the nanocomposites were invest
Anamestic inhibitors represent the major complication of haemophilia therapy now that clotting factor concentrates are virtually free of pathogen-transmission risk. Conventional clotting factor replacement is usually insufficient to prevent or treat bleeding in a haemophilia patient with a high responding inhibitor so that alternative treatment with bypassing agents is required. Despite their rela
ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy me
Abstract: We report on a 1000 year long oxygen isotope record in sediments of the eastern Norwegian Sea which, we argue, represents the temperature and transport of warm Atlantic waters entering the Nordic Sea basin via the North Atlantic Drift and the large-scale Meridional Overturning Circulation. The single-sample resolution of the record is 2.5-10 years and age control is provided by Pb-210 an
Epithelial ovarian carcinoma has in general a poor prognosis since the vast majority of tumors are genomically unstable and clinically highly aggressive. This results in rapid progression of malignancy potential while still asymptomatic and thus in late diagnosis. It is therefore of critical importance to develop methods to diagnose epithelial ovarian carcinoma at its earliest developmental stage,
Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation. The role of the complement system, a pivotal component of human innate immunity, as an important defence against invading pathogens has been well documented and
This article focuses on co-creation as a strategy and the challenge of applying theories of co-creation in practice. Place branding and a co-creative strategy based on art is used as an example of a special type of public relations concerned with building connections between stakeholders and a specific place. This is investigated through an analysis of how key internal stakeholders in a municipali
