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Injury-associated PACAP expression in rat sensory and motor neurons is induced by endogenous BDNF

Peripheral nerve injury results in dramatic upregulation in pituitary adenylate cyclase activating polypeptide (PACAP) expression in adult rat dorsal root ganglia and spinal motor neurons mirroring that described for the neurotrophin brain derived neurotrophic factor (BDNF). Thus, we posited that injury-associated alterations in BDNF expression regulate the changes in PACAP expression observed in

Amorphous silica transport in the Ganges basin: Implications for Si delivery to the oceans

Rivers transport similar to 6 x 10(12) mol yr(-1) of dissolved Si (DSi) from the continents to the oceans. They also carry amorphous silica (ASi), solid phases likely to dissolve in seawater. Unfortunately, the magnitude of this flux is poorly constrained at a global scale. We present 92 new ASi values from suspended particulate matter (SPM) from the Ganges basin. Bulk SPM is 1.2% ASi, and mean AS

Mechanical symptoms and arthroscopic partial meniscectomy in patients with degenerative meniscus tear : A secondary analysis of a randomized trial

Background: Recent evidence shows that arthroscopic partial meniscectomy (APM) offers no benefit over conservative treatment of patients with a degenerative meniscus tear. However, patients who report mechanical symptoms (sensations of knee catching or locking) may benefit from APM. Objective: To assess whether APM improves mechanical symptoms better than sham surgery. Design: Randomized, patient-

The initial evaluation of an Internet-based support system for audiologists and first-time hearing aid clients

Objectives: Audiologists provide professional contact and support between appointments to clients with hearing impairment using telephone and e-mail, but more advanced and flexible technological platforms are also possible. The present study aimed to evaluate the clinical application of an Internet-based support system for audiologists and their first-time hearing aid clients. Design: An Internet-

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc

Cellulosic Bioethanol Production

This chapter discusses some aspects of various separation technologies applied in bioethanol production from lignocellulosic materials. Bioethanol can be produced from lignocellulosic biomass using several different process configurations. The main energy-demanding process steps in lignocellulosic ethanol production are distillation to concentrate the ethanol, adsorption to remove the final conten

Copper induced root growth inhibition of Allium cepa var. Agrogarum L. involves disturbances in cell division and DNA damage

Copper (Cu) is considered to be an indispensable microelement for plants. Excessive Cu, however, is toxic and disturbs severalprocesses in the plant. The present study addressed the effects of ionic Cu (2.0 mMand 8.0mM) on mitosis, the microtubule cytoskeleton,and DNA in root tip cells of Allium cepa var. agrogarum L. to better understand Cu toxicity on plant root systems. The results indicated th

Application of in-house virtual protein database performed in genomic-proteomic combined research on heavy-metal stressed onion roots

Objectives To establish an in-house virtual protein database that can be employed in proteomic research on non-model plants. Results A total of 87,430 unigenes were obtained through transcriptome sequencing from onion roots. Of these, 24,305 unigenes were annotated and their nucleotide sequences of coding regions were translated into amino acid sequences. The corresponding 24,305 amino acid sequen

Symbolic Transformations of Dynamic Optimization Problems

Dynamic optimization problems involving differential-algebraic equation (DAE) systems are traditionally solved while retaining the semi-explicit or implicit form of the DAE. We instead consider symbolically transforming the DAE into an ordinary differential equation (ODE) before solving the optimization problem using a collocation method. We present a method for achieving this, which handles DAE-c

Kan satsningar i primärvården öka produktiviteten i sjukvården?

En rad studier har pekat på att en väl utbyggd primärvård har stor betydelse för både folkhälsa och god resursanvändning inom vården. I denna artikel jämför vi de svenska landstingens sjukvårdsproduktion under perioden 2005–09 och hur produktiviteten i vården varierar med landstingens satsningar på primärvård. Den decentraliserade svenska vårdorganisationen erbjuder goda möjligheter till jämförand

Sovereignty Games : Instrumentalising state sovereignty in Europe and beyond

This book offers an in-depth examination of the strategic use of State sovereignty in contemporary European and international affairs and the consequences of this for authority relations in Europe and beyond. It suggests a new approach to the study of State sovereignty, proposing to understand the use of sovereignty as games where States are becoming more instrumental in their claims to sovereignt

Access to Asylum : International refugee law and the globalisation of migration control.

Is there still a right to seek asylum in a globalised world? Migration control has increasingly moved to the high seas or the territory of transit and origin countries, and is now commonly outsourced to private actors. Under threat of financial penalties airlines today reject any passenger not in possession of a valid visa, and private contractors are used to run detention centres and operate bord

Synchrotron-radiation-excited soft-x-ray-fluorescence studies of Cu and Zn : On the validity of the sudden approximation

The L23 x-ray-emission spectra of Cu and Zn have been recorded using tunable-synchrotron-radiation-excited fluorescence spectroscopy. The satellite structure was studied in detail by varying the excitation energy from threshold to several hundred eV above. Strong satellites are observed which can unambiguously be associated with the decay of multiply excited states. This disproves recent claims of

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The paper focuses on selective investment incentives, which are aimed primarily to attract foreign direct investment, in the context of the new EU Member States, namely the Czech Republic, Hungary, Poland and Slovakia. We discuss the issue within three closely related dimensions. We point to a potential conflict of interests between host country governments and multinational companies in promoting

Infringement of intellectual property in innovation partnerships

Using data from the German Community Innovation Survey (CIS) from 2008, we analyze whether innovation partnering increases the risk of experiencing infringement of intellectual property (IP). The results show that depending on types of IP innovation, partnerships increase the risk of infringement by up to 37% compared with the average risk in the sample. The results suggest that this massive incre

How to use indicators to measure scientific performance : A balanced approach

Scientific performance should not be measured by a one-dimensional metric such as publication, since it is a multi-dimensional phenomenon. A quantitative analysis of the activities of research groups in three scientific fields demonstrates in particular the importance of sufficient numbers of PhD graduates and of contributions to the infrastructure of the scientific community, in terms of editorsh