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A machine learning tool for identifying newly diagnosed heart failure in individuals with known diabetes in primary care

Aims: We aimed to create a predictive model utilizing machine learning (ML) to identify new cases of congestive heart failure (CHF) in individuals with diabetes in primary health care (PHC) through the analysis of diagnostic data. Methods: We used a sex- and age-matched case–control design. Cases of new CHF were identified across all outpatient care settings 2015–2022 (n = 9098). We included indiv

Overuse of analgesics can affect the fertility biomarker Anti-Müllerian Hormone in females. A translational study

Background: Medication overuse headache is a prevalent secondary headache due to the overuse of analgesics, mainly over-the-counter analgesics. Over-the-counter analgesics have been associated with disrupted male endocrinology, while the effects on female endocrinology remain nearly unknown. The aim was to understand the effect of long-term analgesic exposure in females with medication overuse hea

Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells

Apolipoprotein A-I (ApoA-I), the primary component of high-density lipoprotein (HDL) cholesterol primes β-cells to increase insulin secretion, however, the mechanisms involved are not fully defined. Here, we aimed to confirm ApoA-I receptors in β-cells and delineate ApoA-I-receptor pathways in β-cell insulin output. An LRC-TriCEPS experiment was performed using the INS-1E rat β-cell model and ApoA

Prediction of Decay Heat from PWR Spent Nuclear Fuel Using Fuel Parameters

In the context of a geological repository for nuclear waste, fast and accurate predictions of decay heat are needed for different applications ranging from canister loading optimization to comparing decay heat predictions from state-of-the-art codes with experimental measurements. This work uses a large database of simulated pressurized water reactor (PWR) spent nuclear fuel (SNF) with an extensiv

C12 aromatic triol-furoin and diol-furil from bio-based 5-(hydroxymethyl)furfural : enhanced selective synthesis, scale-up and mechanistic insight into cyclic catalysis

In this study, we investigate the valorization of 5-(hydroxymethyl)furfural (5-HMF), a versatile and pivotal renewable C6 platform chemical, into a C12 heteroaromatic triol, 5,5′-bis(hydroxymethyl)furoin (DHMF), and a C12 heteroaromatic diol, 5,5′-bis(hydroxymethyl)furil (BHMF). The carboligation of 5-HMF to DHMF is catalyzed by an N-heterocyclic carbene, 1,3,4-triphenyl-4,5-dihydro-1H-1,2,4-triaz

The Elucidation of the Phenomenology of the Picture Sign from Its Phaneroscopy, and Vice Versa

The aim of this chapter is to suggest that the method which Husserl and Peirce both called phenomenology is, in important respects, the same, and that the differences are found not where they were claimed to be. Certain exponents of both kinds of phenomenologies, on the Peircean side, Joseph Ransdell, and on the side of Husserl, Herbert Spiegelberg, have stated that they are incompatible. This pap

Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50–64 Years

Rationale: Knowledge regarding the prevalence and shared and unique characteristics of the restrictive spirometric pattern (RSP) and preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with post-bronchodilator spirometry and computed tomography of the lungs. Objectives: To investigate shared and unique features for RSP and PRISm. Methods: In the Swedish CAr

Resting-State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response : A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy

Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder

Xputer : bridging data gaps with NMF, XGBoost, and a streamlined GUI experience

The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp

Alterations of the chemical profile of cholesterol in cancer tissue as traced with ToF-SIMS

Cancer has become one of the leading causes of death, with approximately ten million people worldwide dying from cancer each year. In most cases, cancer spreads to remote organs and develops a resistance to therapy. To reduce the deadly impact of cancer, novel targets for markers for early detection are necessary. Given the notable influence of rapid chemical turnover on isotope effects, the heigh

Composition tunable and stable spontaneous emission and lasing in Cd-alloyed perovskite microdisks

All-inorganic Pb-Cd mixed-cation halide perovskites have emerged as semiconductors exhibiting improved optical and optoelectronic properties. We establish a reliable correlation between photoluminescence and Cd content x in bulk CsPb1−xCdxBr3 compositions, propose pathways of photoexcited charge carrier dynamics in them, and show improved stability of lasing in whispering gallery mode microdisks.

Efficient assignment of identities in anonymous populations

We consider the fundamental problem of assigning distinct labels to agents in theprobabilistic model of population protocols. Our protocols operate under the assumptionthat the size n of the population is embedded in the transition function. W.h.p. (withhigh probability), they are silent, i.e., eventually each agent reaches its nal state andremains in it forever, and they are safe, i.e., never cha

Assembling Our Digital Selves

This performance lecture dealt with plan b's ongoing practice of twenty years of collecting personal data, which has been the basis for a number of art works and performances over the years. As artists, educators and researchers, we have deliberately intermingled our art and life, be it through collecting GPS traces of everywhere we go or shouting all our text messages to one another. For us, the

South Asian Nationalisms: Guest Editors' Introduction

This article intends to raise questions related to nationalism in South Asia, whilealso addressing the rationale for this special issue. Is nationalism a monolithicconstruct based on a European precedent or is it something much larger that isdeveloped pluralistically in a variety of contexts around the world? If the latteris true, which is our position, then how do we go about studying the variousThis article intends to raise questions related to nationalism in South Asia, while also addressing the rationale for this special issue. Is nationalism a monolithic construct based on a European precedent or is it something much larger that is developed pluralistically in a variety of contexts around the world? If the latter is true, which is our position, then how do we go about studying the var

Loss of glymphatic homeostasis in heart failure

Heart failure (HF) is associated with progressive reduction in cerebral blood flow (CBF) and neurodegenerative changes leading to cognitive decline. The glymphatic system is crucial for the brain's waste removal, and its dysfunction is linked to neurodegeneration.In this study, we used a mouse model of HF, induced by myocardial infarction (MI), to investigate the effects of HF with reduced ejectio

Phylogenomic insights into the relationship and the evolutionary history of planthoppers (Insecta: Hemiptera: Fulgoromorpha)

Planthoppers (Hemiptera: Fulgoromorpha) are a species-rich and globally distributed insect clade with high economic, ecological and evolutionary importance. However, the relationships among planthopper lineages and families remain unclear. Previous efforts based on inconsistent morphological traits, a few genes or limited sampling often resulted in conflicting tree topologies. Here, we used genome

Pervasive horizontal transmission of Wolbachia in natural populations of closely related and widespread tropical skipper butterflies

BACKGROUND: The endosymbiotic relationship between Wolbachia bacteria and insects has been of interest for many years due to their diverse types of host reproductive phenotypic manipulation and potential role in the host's evolutionary history and population dynamics. Even though infection rates are high in Lepidoptera and specifically in butterflies, and reproductive manipulation is present in th

School performance gap between non-immigrant and secondgeneration immigrant children in Sweden -time trends and contributing factors

We aimed to investigate the school performance gap and its potential trend from 2010 to 2020 in non-immigrant and second-generation immigrant children in Sweden, whether parental mental disorders and low socioeconomic status contribute to this gap and its trends, and whether the effects of these factors differ by immigration status. We used multiple Swedish population registers, including 829,787

Swedish State Property at the King’s Disposal: The Historical Development of the Legal Arrangements Concerning the Swedish Royal Palaces and the Financing of the Swedish Royal Family

Since the Middle Ages, there have been Crown estates in Sweden that were to be used by the King. In 1809-10, an agreement was reached between King and Parliament about the financing of the expenses of the Royal Family and the Royal Household and of the right of the King and the Royal Family to use and govern the Royal Palaces. This agreement is still in force, although it has been amended as regarSince the Middle Ages, there have been Crown estates in Sweden that were to be used by the King. In 1809-10, an agreement was reached between King and Parliament about the financing of the expenses of the Royal Family and the Royal Household and of the right of the King and the Royal Family to use and govern the Royal Palaces. This agreement is still in force, although it has been amended as regar