AIM: Schizophrenia is associated with high cardiovascular mortality predominantly as a result of acute coronary syndrome (ACS). The aim of this study is to analyze time trends of coronary procedures, guideline-based therapy, and all-cause mortality in patients diagnosed with schizophrenia.METHODS AND RESULTS: This Danish nationwide register-based study analyzed 734 patients with a baseline diagnos

As one of the most important texts of the apostle Paul, Galatians offers a goodstarting-point for an investigation of Paul’s argumentation. The letter is polemical and contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Although the argumentation of Paul is often an issue within New Testament exAs one of the most important texts of the apostle Paul, Galatians offers a goodstarting-point for an investigation of Paul’s argumentation. The letter is polemical and contains a substantial amount of argumentative passages. Paul evidently wanted to persuade by using the best arguments possible to convince his addressees. Although the argumentation of Paul is often an issue within New Testament ex

The purpose of this paper is to more fully develop the notion of the international identity of the EU previously suggested by Richard Whitman and myself. I will attempt to balance our previous focus on the ‘active dimension’ of the EU’s attempts to ‘assert its identity on the international scene’ by looking at the ‘reflexive dimension’ of the EU’s international identity from a more sociological pe

BACKGROUND: Sodium-glucose co-transporter (SGLT) inhibitors reduce cardiovascular outcomes including mortality in several populations; however, their effect on atrial fibrillation/flutter (AF) remains unclear. Our objective was to determine whether SGLT inhibitors reduce AF and whether a history of AF modifies the effect of SGLT inhibitors on the composite of heart failure hospitalization or cardi

Glyoxalase I (GlxI) is a member of the glyoxalasesystem, which is important in cell detoxification and convertshemithioacetals of methylglyoxal (a cytotoxic byproduct of sugarmetabolism that may react with DNA or proteins and introducenucleic acid strand breaks, elevated mutation frequencies, andstructural or functional changes of the proteins) and glutathioneinto D-lactate. GlxI accepts both the

Purpose: The purpose of this work was to establish an empirical model of the ion recombination in the Advanced Markus ionization chamber for measurements in high dose rate/dose-per-pulse electron beams. In addition, we compared the observed ion recombination to calculations using the standard Boag two-voltage-analysis method, the more general theoretical Boag models, and the semiempirical general

Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy

Purpose: The purpose of this paper is to contribute to a better understanding of the occurrence of strategic error in using key performance indicators (KPIs) in innovation Design/methodology/approach: This case study was conducted at the innovation department of an organization in the process industry that operates production sites and sales organisations worldwide. Observations and interviews werTo date, measuring innovation has not been an exact science. As in many areas of organizational life, errors in measuring innovation are a recurring fact. Innovation researchers and practitioners alike have become increasingly interested in understanding the occurrence of organizational errors and how these errors affect innovation and its measurement. This empirical study aims to address this und

Adequate setting of the boundary conditions for the heat equation when modeling the temperature distribution in the cutting tool is one of the key points. The boundary conditions on the tool surfaces can be divided into two groups: conditions that describe heat losses (heat exchange with the environment) and conditions that characterize the heat source that heats up the tool (heat flux from the cu

Iron and steel production is responsible for 7% of global greenhouse gas emissions. Earlier literature finds that the long economic life of steel production equipment impedes decarbonization in line with climate targets. Here, we estimate the cumulative emissions from existing primary steel production equipment if operated as historically observed, based on furnace-level data of historical operati

Tree-killing bark beetles are the most economically important insects in conifer forests worldwide. However, despite >200 years of research, the drivers of population eruptions and crashes are still not fully understood and the existing knowledge is thus insufficient to face the challenges posed by the Anthropocene. We critically analyze potential biotic and abiotic drivers of population dynamics

Agricultural intensification based on smallholders is among many economists viewed as a necessary developmental path to ensure food security and poverty reduction in sub-Saharan Africa. Increasingly, a one-sided focus on raising productivity in cereals has been questioned on environmental grounds, with the concept of sustainable agricultural intensification (SAI) emerging from the natural sciences

Summary: The existing information supports the use of this material as described in this safety assessment.2-Propanol, 1,1',1',1'-(1,2-ethanediyldinitrilo)tetrakis- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the target material and read-across an

Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature

The new luminescent carbonyl compounds [Mn(Oxa-H)(CO)3Br] (1) and [Mn(Oxa-NMe2)(CO)3Br] (2) were synthesized and fully characterized. Complexes 1 and 2 showed CO release under blue light (λ453). Spectroscopic techniques and TD-DFT and SOC-TD-DFT calculations indicated that 1 and 2 release the Oxa-H and Oxa-NMe2 coligands in addition to the carbonyl ligands, increasing the luminescence during photo

The photoionization of xenon atoms in the 70–100 eV range reveals several fascinating physical phenomena such as a giant resonance induced by the dynamic rearrangement of the electron cloud after photon absorption, an anomalous branching ratio between intermediate Xe+ states separated by the spin-orbit interaction and multiple Auger decay processes. These phenomena have been studied in the past, u

Social media companies have resorted to censorship to suppress misinformation about the COVID-19 pandemic. This is not the most prudent solution though given the uncertainties about the disease.

Appearance of metazoans with mineralized skeletons, “explosion” in biotic diversity and disparity, infaunalization of the substrate, occurrence of metazoan Konservat Fossil-lagerstätten, establishment of most invertebrate phyla, strong faunal provincialism, dominance of trilobites, generally warm climate but with possibleglacial-interglacial cycles in the later part, opening of the Iapetus Ocean,

Increasing global light pollution1,2 threatens the night-time darkness to which most animals are adapted. Light pollution can have detrimental effects on behavior,3–5 including by disrupting the journeys of migratory birds,5,6 sand hoppers,7–9 and moths.10 This is particularly concerning, since many night-active species rely on compass information in the sky, including the moon,11,12 the skylight