PURPOSE: The partial volume effect (PVE) is an important source of bias in brain perfusion measurements. The impact of tissue PVEs in perfusion measurements with dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. The purpose of this study was to suggest a partial volume correction (PVC) approach for DSC-MRI and to study how PVC affects DSC-MRI perfusion results.METHOD

OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The

Objectives: Thoracic spine radiography becomes more difficult with age. Tomosynthesis is a low-dose tomographic extension of radiography which may facilitate thoracic spine evaluation. This study assessed the added value of tomosynthesis in imaging of the thoracic spine in the elderly. Methods: Four observers compared the image quality of 50 consecutive thoracic spine radiography and tomosynthesis

Introduction and Aims: Injecting opioid users are at elevated risk of death. Although liver disease (especially hepatitis C) is common, its impact on mortality is low in active injectors. Because opioid substitution therapy (OST) reduces the risk of death from directly drug related causes, we hypothesised that the proportion of liver-related deaths would increase in subjects receiving OST. We inve

The commissioning and operations planning for the European Spallation Source is currently being defined. It is foreseen that the ESS will begin to deliver beam on target by mid 2019, something which is urging a well structured and thought through plan both for commissioning and operations. In this paper we will discuss the plans for beam physics operational software, priorities and software servic

The European Spallation Source, ESS, uses a linear accelerator to bombard the tungsten target with the high intensity protons beam for producing intense beams of neutrons. The nominal average beam power of the linac is 5~MW with a peak beam power at target of 125~MW. This paper focuses on the beam dynamics design of the ESS linac and the diagnostics elements used for the tuning of the lattice and

This article investigates the informal networks of Member States that are claimed to be the drivers of EU gender and development policy. The aim is to highlight the negotiation strategies used in gender and development negotiations and to link these to network characteristics. I categorise the characteristics of the Nordic and the like-minded groupings, relying on network theory and investigate th

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fusions. We describe a subtype characterized by recurrent IGH-DUX4 or ERG-DUX4 fusions, representing 4%

In this paper we present a two-dimensional framework for analysis of research on standards and standardization and its implications for strategic management. Existing research is organized and analyzed, demonstrating that despite the multifaceted nature of the field, patterns and logics are exposed by applying the suggested theoretical framework - its two analytical dimensions being the level of a

We consider a real-time system of multiple tasks, each task having a plant to control. The overall quadratic control cost is to be optimized. We exploit the periodicity of the task response time, which corresponds to a periodic delay pattern in the feedback control loop. Perturbed periods are used as a tool to find a finite hyperperiod. We present an analytical procedure to design a periodic linea

Environmental humidity influences the fitness and geographic distribution of all animals [1]. Insects in particular use humidity cues to navigate the environment, and previous work suggests the existence of specific sensory mechanisms to detect favorable humidity ranges [2-5]. Yet, the molecular and cellular basis of humidity sensing (hygrosensation) remains poorly understood. Here we describe gen

Alarm pheromones are important semiochemicals used by many animal species to alert conspecifics or other related species of impending danger. In this review, we describe recent developments in our understanding of the neural mechanisms underlying the ability of fruit flies, zebrafish and mice to mediate the detection of alarm pheromones. Specifically, alarm pheromones are detected in these species