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Reflexivt ledarskap

Ett reflexivt ledarskap handlar om att överväga vad vi menar med ledarskap, vad det kan göra och inte göra, när det kan fungera och när det inte är bästa alternativet. Författarnas ambition är att uppmuntra chefer och andra att tänka både bredare och djupare om hur man bäst samordnar arbete i moderna organisationer. I detta ingår att även lyfta fram och diskutera alternativen till ledarskap.Boken

Kepler-11 is a Solar Twin : Revising the Masses and Radii of Benchmark Planets via Precise Stellar Characterization

The six planets of the Kepler-11 system are the archetypal example of a population of surprisingly low-density transiting planets revealed by the Kepler mission. We have determined the fundamental parameters and chemical composition of the Kepler-11 host star to unprecedented precision using an extremely high-quality spectrum from Keck-HIRES (R ≃ 67,000, S/N per pixel at 600 nm). Contrary to previ

Label-free single-cell separation and imaging of cancer cells using an integrated microfluidic system

The incidence of cancer is increasing worldwide and metastatic disease, through the spread of circulating tumor cells (CTCs), is responsible for the majority of the cancer deaths. Accurate monitoring of CTC levels in blood provides clinical information supporting therapeutic decision making, and improved methods for CTC enumeration are asked for. Microfluidics has been extensively used for this pu

Vocational situation and experiences from the work environment among individuals with neuromuscular diseases

BACKGROUND: Neuromuscular diseases (NMD) can affect the ability to be employed and to work, but there is limited knowledge of individuals' own perspectives of factors that are important for their vocational situation. OBJECTIVE: To explore the vocational situation among people with NMD that are employed, and to describe their experiences of how their disability, personal and environmental factors

Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide

OBJECTIVES: Plant-derived natural substances, such as capsaicin, with potent antiproliferative activity against cancer cells in vitro are considered to be promising nutraceuticals in anticancer therapy. Nevertheless, the limited systemic bioavailability of phytochemicals may raise questions regarding the physiological relevance of their phytochemical effects in vivo. Thus, the search for novel phy

Radiographic prevalence of scaphotrapeziotrapezoid osteoarthrosis

PURPOSE: To define the radiographic prevalence of scaphotrapeziotrapezoid (STT) osteoarthrosis (OA) in a cohort of patients presenting to a hand surgeon for any complaint. The secondary purpose was to evaluate coexisting thumb carpometacarpal (CMC) joint OA.METHODS: Seven hundred radiographs were evaluated for presence and degree of STT and thumb CMC arthritic changes in consecutive patients prese

Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins

Class 3 semaphorins were discovered as a family of axon guidance molecules, but are now known to be involved in diverse biologic processes. In this study, we investigated the anti-angiogenic potential of SEMA3E and SEMA3F (SEMA3E&F) in infantile hemangioma (IH). IH is a common vascular tumor that involves both vasculogenesis and angiogenesis. Our lab has identified and isolated hemangioma stem

Salutogenic resources in relation to teachers' work-life balance

BACKGROUND: Experiencing work-life balance is considered a health promoting resource. To counter-balance the negative development of teachers' work situation, salutogenic resources need to be examined among teachers. OBJECTIVE: To examine resources related to teachers' experience of their work-life balance. METHODS: Using a cross-sectional design, a questionnaire was distributed to 455 teachers in

Long-term third-party assessment of results after continent cutaneous diversion with Lundiana pouch

Objectives: To investigate the long-term functional outcomes and complications after continent cutaneous diversion with the Lundiana pouch. Patients and Methods: Complications, re-operations, renal function, and continence were ascertained from patient charts. Outcome variables were validated by a second and independent review of the patient files. Results: A complication of Clavien-Dindo grade ≥I

Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation

Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donor

Syndecan Heparan Sulfate Proteoglycans: Regulation, Signaling and Impact on Tumor Biology

Virtually all animal cells express heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Syndecans are a major group of transmembrane proteoglycans functioning as receptors that mediate signal transmission from the extracellular microenvironment to the cell. Their heparan sulfate chains, due to their vast structural diversity, interact with a wide array of ligands incl

Discrepancies between the one-stage clotting assay and the chromogenic assay in haemophilia B

Introduction: Assay discrepancy in factor VIII activity between the one-stage and the chromogenic assays has been described in approximately one third of patients with non-severe haemophilia A. Whether assay discrepancy may also occur in patients with haemophilia B remains unknown. Aim: This study compared the results from the one-stage and the chromogenic assays in patients with haemophilia B. Me

Graphical robot programming: requirements and existing systems

The use of a graphical system for the programming of industrial robots offers a number of advantages. Graphical systems employ an interface that is much easier to use. The resulting motion trajectories can be simulated and tested for collisions or singular points. Contemporary graphical systems use the geometry of the objects that are to be handled or processed in order to generate robot motion tr

Resilience in the European Union: the effect of the 2008 crisis on the ability of regions in Europe to develop new industrial specializations

This article adopts an evolutionary framework to the study of industrial resilience. We present a study on European regions and assess the extent to which the capacity of their economies to develop new industrial specializations is affected by the global economic crisis of 2008. We compare levels of industry entry in European regions in the period 2004–2008 and 2008–2012, i.e. before and after a m