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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls)

Multi-lepton production at high transverse momenta in ep collisions at HERA

Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full e(+/-) p data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb(-1). Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of e(+)e(-) and mu(+)mu(-) pairs are derived in a re

The Usefulness of Negative Valve Overlap for Gasoline Partially Premixed Combustion, PPC

Partially premixed combustion has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions, even at higher loads. The problem is the ignitability at low load and idle operating conditions. The objective is to investigate the use

Feasibility of neuromuscular training in patients with severe hip or knee OA: The individualized goal-based NEMEX-TJR training program

Background: Although improvements are achieved by general exercise, training to improve sensorimotor control may be needed for people with osteoarthritis (OA). The aim was to apply the principles of neuromuscular training, which have been successfully used in younger and middle-aged patients with knee injuries, to older patients with severe hip or knee OA. We hypothesized that the training program

Symboler i Dalby

Interpretations of the church, monastery and manor of Dalby have focused primarily on the history and functions of the buildings, but symbolic interpretations have been involved too. The article discusses four categories of symbolic interpretations: Power Symbols, Cosmic Symbols, Biblical Symbols and Geographical Symbols. The conclusion is that it is hard, when dealing with specific buildings, to

Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet-Spengler approach

A protocol for the diastereoselective synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via Pictet-Spengler condensation with L-DOPA or L-DOPA derivatives and 1H-indole-3-carbaldehydes is presented. The protocol is used for the successful synthesis of several tetrahydroisoquinolines as well as diketopiperazine fused analogues. (C) 2012 Elsevier Ltd. All rights reserved.

Algebraic Discretization of the Camassa-Holm and Hunter-Saxton Equations

The Camassa-Holm (CH) and Hunter-Saxton (HS) equations have an interpretation as geodesic flow equations on the group of diffeomorphisms, preserving the H-1 and. H-1 right-invariant metrics correspondingly. There is an analogy to the Euler equations in hydrodynamics, which describe geodesic flow for a right-invariant metric on the infinite-dimensional group of diffeomorphisms preserving the volume

Moraxella catarrhalis outer membrane vesicles carry beta-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin.

Moraxella catarrhalis is a common pathogen found in children with upper respiratory tract infections, and in patients with chronic obstructive pulmonary disease during exacerbations. The bacterial species is often isolated together with Streptococcus pneumoniae and Haemophilus influenzae. Outer membrane vesicles (OMV) are released by M. catarrhalis and contain phospholipids, adhesins, and immunomo

Efficient Parallel Solution of Large-Scale Nonlinear Dynamic Optimization Problems

This paper presents a decomposition strategy applicable to DAE constrained optimization problems. A common solution method for such problems is to apply a direct transcription method and solve the re- sulting nonlinear program using an interior-point algorithm. For this approach, the time to solve the linearized KKT system at each iteration typically dominates the total solution time. In our propo

Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in pp collisions at root s=8 TeV

The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3 fb(-1) of data collected in proton-proton collisions at root s = 8 TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS

Release characteristic of different classes of sodium during combustion of Zhun-Dong coal investigated by laser-induced breakdown spectroscopy

Serious fouling and slagging problems are associated with the combustion of Chinese Zhun-Dong coal due to its high content of sodium (Na). Understanding the release characteristic of Na during the combustion is essential to viable utilization of this coal. In this work, coal samples were treated with a sequence of solvents: water (H2O), ammonium acetate (NH4Ac), hydrochloric acid (HCl), and the re

Ethnic differences in breast cancer risk and survival: A study on immigrants in Sweden

Background. There are large geographic differences in breast cancer risk but whether survival differs between low- and high-risk groups is less well-established. As the survival of cancer depends on the level of healthcare and awareness of disease risks, subtle differences in cancer biology cannot be revealed in international comparisons. Instead, comparison of diverse immigrant groups in a countr

Liquid Crystal Phases in Suspensions of Charged Plate-Like Particles

Anisotropic interactions in colloidal suspensions have recently emerged as a route for the design of new soft materials. Nonisotropic particles can form nematic, smectic, hexatic, and columnar liquid crystals. Although the formation of these phases is well rationalized when excluded volume is solely at play, the role of electrostatic interactions still remains unclear and even less so when particl

Adsorption of methylamine on Ni3Al(111) and NiAl(110)-a high resolution photoelectron spectroscopy and density functional theory study

Methylamine adsorption on the ordered Ni3Al(111) and NiAl(110) surfaces has been investigated by high resolution photoelectron spectroscopy and density functional theory calculations. Methylamine adsorbs molecularly at both surfaces at low temperature (90 K). The experiments show that methylamine interacts with the surface aluminium atoms on both surfaces, resulting in a positive binding energy sh

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Abstract in French Cette étude vise à mettre en lumière l’acquisition de la liaison préverbale en tant qu’accord sujet-verbe en nombre en français langue étrangère (FLE). Le but principal de l’étude est d’examiner le développement de ce trait morpho-phonologique et d’évaluer l’impact de la fréquence du verbe pour l’emploi de la liaison préverbale en FLE. Nous présentons une étude transversale où 4