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Expression and phylogenetic analyses reveal paralogous lineages of putatively classical and non-classical MHC-I genes in three sparrow species (Passer)

Background: The Major Histocompatibility Complex (MHC) plays a central role in immunity and has been given considerable attention by evolutionary ecologists due to its associations with fitness-related traits. Songbirds have unusually high numbers of MHC class I (MHC-I) genes, but it is not known whether all are expressed and equally important for immune function. Classical MHC-I genes are highly

Structural Characterization of Histatin 5-Spermidine Conjugates : A Combined Experimental and Theoretical Study

Histatin 5 (Hst5) is a naturally occurring antimicrobial peptide that acts as the first line of defense against oral candidiasis. It has been shown that conjugation of the active Hst5 fragment, Hst54-15, and the polyamine spermidine (Spd) improves the candidacidal effect. Knowledge about the structure of these conjugates is, however, very limited. Thus, the aim of this study was to characterize th

β-admissibility of observation operators for hypercontractive semigroups

We prove a Weiss conjecture on (Formula presented.)-admissibility of observation operators for discrete and continuous (Formula presented.)-hypercontractive semigroups of operators, by representing them in terms of shifts on weighted Bergman spaces and using a reproducing kernel thesis for Hankel operators. Particular attention is paid to the case (Formula presented.), which corresponds to the unw

Optimal Quantum Interference Thermoelectric Heat Engine with Edge States

We show theoretically that a thermoelectric heat engine, operating exclusively due to quantum-mechanical interference, can reach optimal linear-response performance. A chiral edge state implementation of a close-to-optimal heat engine is proposed in an electronic Mach-Zehnder interferometer with a mesoscopic capacitor coupled to one arm. We demonstrate that the maximum power and corresponding effi

Linking content and technology : on the geography of innovation networks in the Bergen media cluster

This paper deals with the geography of innovation networks and analyses combinatorial knowledge dynamics from a single cluster perspective. Addressing firms in the media cluster in Bergen, Norway, we examine how and from where companies acquire and combine different types of knowledge for their innovation activities. The empirical analysis, which is based on structured interviews with 22 media com

A unified account of the conjunction fallacy by coherence

We propose a coherence account of the conjunction fallacy applicable to both of its two paradigms (the M–A paradigm and the A–B paradigm). We compare our account with a recent proposal by Tentori et al. (J Exp Psychol Gen 142(1): 235–255, 2013) that attempts to generalize earlier confirmation accounts. Their model works better than its predecessors in some respects, but it exhibits only a shallow

A generalized Sibuya distribution

The Sibuya distribution arises as the distribution of the waiting time for the first success in Bernoulli trials, where the probabilities of success are inversely proportional to the number of a trial. We study a generalization that can be viewed as the distribution of the excess random variable (Formula presented.) given (Formula presented.), where N has the Sibuya distribution and k is an intege

What drives academic patentees to bypass TTOs? Evidence from a large public research organisation

This paper provides insights into the behavior of academic patentees who choose to bypass in-house Technology Transfer Offices (TTOs). TTOs have gained favor in recent years as academic institutions have tried to increase commercialization of their inventions. Using a large sample of researchers at a leading German public research organisation (PRO), results show that patentees in physical and lif

From citizenship to mobile commons : reflections on the local struggles of undocumented migrants in the city of Malmö, Sweden

Focusing on undocumented migrants’ struggles over rights and representation in the city of Malmö, Sweden, this article argues that these practices constitute an enactment of citizenship. Drawing on the literature on autonomy of migration, we also explore acts of solidarity beyond the terminology of citizenship through the concept of ‘mobile commons’. We focus on experiences and activist practices

On the dissolution of cellulose in tetrabutylammonium acetate/dimethyl sulfoxide : a frustrated solvent

We have found that the dissolution of cellulose in the binary mixed solvent tetrabutylammonium acetate/dimethyl sulfoxide follows a previously overlooked near-stoichiometric relationship such that one dissolved acetate ion is able to dissolve an amount of cellulose corresponding to about one glucose residue. The structure and dynamics of the resulting cellulose solutions were investigated using sm

An archaeology of societal resilience

There seems to be a worldwide push, through policy and Government campaigns, to emphasise a local and decentralised responsibility for societal safety and security. Often, this push is argued for using the notion of resilience. Using an archaeological approach this paper sets out to analyse the conditions of possibility for resilience to get established as an object of knowledge within the discour

The complexity of resources related to work-life balance and well-being – a survey among municipality employees in Sweden

Increasing sickness absence rates among care and service employees in Sweden motivate health-promoting activities. It is crucial to employers and key stakeholders, like HRM departments, to have knowledge of resources related to employees' work life balance (WLB) to increase well-being at work. The aim of the study was to explore resources associated with WLB, with focus on work and private lives a

The Impact of Different Drying Techniques and Controlled Storage on the Development of Advanced Glycation End Products in Skim Milk Powders Using Isotope Dilution ESI-LC-MS/MS

The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

The aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is a defining characteristic of Alzheimer's disease. Because of the complexity of this aggregation process, effective therapeutic inhibitors will need to target the specific microscopic steps that lead to the production of neurotoxic species. We introduce a strategy for generating fibril-specific antibodies that selectively suppres

Exploring low carbon transition pathways for the UK road transport sector

This paper uses an analytical framework of multi-level and multi-phase perspectives to explore low carbon transition pathways for the UK road transport system. The work draws on the impact made by the national (UK) and regional (EU) low carbon policy instruments on the UK road sector. The results show that the transformation pathway, which is at the take-off phase on a large scale, is the only ful

The 'good life' of nations : A global perspective

Major socio-ecological issues such as climate change have a global character. For the atmosphere it does not matter from which point in the world greenhouse gases are emitted. The structural preconditions for any ‘good life’ likewise have global reach. In this chapter, we theorise and operationalise the individual, social and ecological dimensions for prosperity and the ‘good life’ at national lev

Effects of detailed illustrations on science learning : an eye-tracking study

The eye-tracking method was used to assess the influence of detailed, colorful illustrations on reading behaviors and learning outcomes. Based on participants’ subjective ratings in a pre-study, we selected eight one-page human anatomy lessons. In the main study, participants learned these eight human anatomy lessons; four were accompanied by detailed illustrations, and the other four were accompa

Sparse source location for real aperture radar using generalized sparse covariance fitting

Source location for real aperture radar (RAR) has raised many concerns in the fields of ground-based monitoring for aircrafts and vessels. Notably, the resolution of RAR in azimuth is constrained by the antenna beam width, which results in low degree of location accuracy. In this paper, we exploit the inherent sparseness of the target distributions to formulate a superresolution methodology to loc