Introduction: This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma. Methods: In this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and

We consider the problem of grid-forming control of power converters in low-inertia power systems. Starting from an average-switch three-phase power converter model, we draw parallels to a synchronous machine (SM) model and propose a novel converter control strategy which dwells upon the main characteristic of a SM: the presence of an internal rotating magnetic field. In particular, we augment the

We detail here the convergence properties of a new model-independent imaging method, the Lévy expansion, that seems to play an important role in the analysis of the differential cross section of elastic hadron-hadron scattering. We demonstrate, how our earlier results concerning the Odderon effects in the differential cross-section of elastic proton-proton and proton-antiproton scattering as well

Review of Heimir Pálsson, Örlagasaga eyfirðings

This paper gives an overview of some feedback & control systems at Synchrotron SOLEIL that are in use or in development today. Beam stability is crucial and adressed in all SOLEIL aspects; Fast Orbit Feedback is a multi-input multi-output control system made to stabilize beam position perturbations in the low- & high frequency band. In addition, active RF cavities are used to maintain stab

Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to

Objectives Global incidence and attention to childhood cancer is increasing and treatment abandonment is a major cause of treatment failure in low-and middle-income countries. The purpose of this study was to gain an understanding of factors contributing to non-adherence to treatment. Design A prospective cohort study with 2 year follow-up of incidence, family-reported motives and risk factors. Se

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm

Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol based on a combination of CD146 with CD117 and CD326 which provides an up to thirty fold enrichment of the DP cells. We show by expression profiling

With growing tourism in natural areas, monitoring recreational impacts is becoming increasingly important. This paper aims to evaluate how di_erent trampling intensities a_ect some common Icelandic plant communities by using digital photographs to analyze and quantify vegetation in experimental plots and to monitor vegetation recovery rates over a consecutive three-year period. Additionally, it se

The urban water crisis, including issues of water scarcity, pollution and flooding, is one of the key challenges for sustainable urban development. Reasons are manifold. Preventive measures are for instance being put on the back burner, while re-active measures and siloed governance are daily business, resulting in power struggles and ineffective governance. As the water crisis hits the most vulneWe are in the midst of a water crisis. Scarcity, pollution and flooding are some of today’s key challenges for sustainable urban development. The reasons are manifold. Preventive measures are put on the back burner, while reactive measures, siloed governance approaches and power struggles are daily business, resulting in ineffective governance. The crisis is hitting the most vulnerable urban popul

OBJECTIVE: To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS: We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia: 66 ± 10 years, 58% M) classified for positivity (±) of amyloid (A) ([18F]Flor

Background Excess weight gain throughout adulthood can lead to adverse clinical outcomes and are influenced by complex factors that are difficult to measure in free-living individuals. Metabolite profiling offers an opportunity to systematically discover new predictors for weight gain that are relatively easy to measure compared to traditional approaches. Methods and results Using baseline metabol

The divide between interest groups and social movement studies runs deep, but present developments call for a renewed focus on the relevance of these analytical categories. Both of these two forms of collective action relate to organisations that are assumed to follow distinctive logics and strategies for political influence. This article aims to contribute to the debates on the analytical differe