Since Pakistan is vulnerable to changing climatic conditions, the country needs emergency measures at every level to mitigate their effect. Many studies have addressed Corporate Social Responsibility (CSR) at the macro or institutional level, but its effect at the micro-level is largely ignored in the contemporary literature. The present study aims at filling this gap by highlighting the role of m

The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or non-existence. A new experiment based on 8He(p, 2p)7H{t+4n} reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system. © 2021, The Au

Background: Patients with bladder pain syndrome experience debilitating pain and extreme frequency of urination. Numerous therapeutic approaches have been tested, but as the molecular basis of disease has remained unclear, specific therapies are not available. Objective: Recently, a systematic gene deletion strategy identified interleukin-1 (IL-1) hyperactivation as a cause of severe cystitis in a

AIM: At presentation, 15-20% of patients with rectal cancer already have synchronous liver metastases. The aim of this study was to determine the surgical and survival outcomes in patients with advanced rectal cancer who underwent combined pelvic exenteration and liver (oligometastatic) resection.METHOD: Data from 20 international institutions that performed simultaneous pelvic exenteration and li

Background: Pelvic exenteration for locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) is technically challenging but increasingly performed in specialist centres. The aim of this study was to compare outcomes of exenteration over time.Methods: This was a multicentre retrospective study of patients who underwent exenteration for LARC and LRRC between 2004 and 2015. Su

OBJECTIVE: Palliative pelvic exenteration (PPE) is a technically complex operation with high morbidity and mortality rates, considered in patients with limited life expectancy. There is little evidence to guide practice. We performed a systematic review to evaluate the impact of PPE on symptom relief and quality of life (QoL).METHODS: A systematic review was conducted according to the PRISMA guide

We present and validate a simulation package for simulating the signal generated from arbitrary acousto-optical interaction in scattering media. We further present an example on how the package can be used as a virtual lab.

Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA

This thesis is composed of six papers, which all concern different methods and tools used for the analysis of barcodes in nanochannel-based Optical DNA Mapping (ODM). The first four papers consider densely-labeled barcodes while the last two consider sparsely-labeled barcodes.Paper I presents a combinatorial auction algorithm for contig assembly ussing ODM barcodes as scaffolds.Paper II concerns m

This book presents a comprehensive history of law and religion in the Nordic context. The entwinement of law and religion in Scandinavia encompasses an unusual history, not widely known yet important for its impact on contemporary political and international relations in the region. The volume provides a holistic picture from the first written legal sources of the twelfth century to the law of the

Interaction of H2S and basaltic rocks in volcanic geothermal areas can originate from natural up-flow of magmatic fluids or H2S artificial re-injection in relation to geothermal exploitation, both causing pyrite mineralization. We study the possibility to track these processes with electrical impedance field measurements. Electrical Resistivity Tomography (ERT) and Time- Domain Induced Polarizatio

The pathogenesis of severe infectious diseases is a complex interplay between the host and the pathogen. The development and progression of a disease encompasses a multitude of processes, which balance between host-damage and host-protection. Proteomic analysis provides the necessary tools to interpret the extensive protein networks of host-pathogen interactions underlying the pathogenesis of a pa

An important part of Sweden’s first freedom of religion act, passed in 1951, was citizens’ right not to practice a religion. The post-World War II generations lived in an increasingly secularized paradigm. In this context, Göran Göransson was a very knowledgeable and influential jurist who not only practiced ecclesiastical law within the Swedish church but also served as a departmental jurist acti

BACKGROUND: The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human cortical spheroids (hCSs), offer a pragmatic solution to this issue. In particular, hCSs are an accessible method for generating homogenous organoids of dorsal

We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alex

Purpose: In spine surgery single item patient-reported outcome assessment has been used for many years. Items 1 and 2 of SF-36 are used for assessment of general health. We used these items to explore single item, self-rated, general health assessment after spine surgery. Methods: Patients operated for lumbar disc herniation or lumbar spinal stenosis between 2007 and 2017, were recruited from the