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Background: Tuberous sclerosis (TSC) is a rare genetic disorder associated with a high prevalence of drug-resistant epilepsy (DRE), for which epilepsy surgery may be a viable therapeutic option. National prospective studies with long-term follow-up (LTFU) and the identification of outcome predictors are needed.Methods: Individuals with TSC but no history of previous epilepsy surgery were identifie
Leapfrog migration is a common migration pattern in birds where the breeding and wintering latitudes between populations are in reversed latitudinal sequence. Competition for wintering and breeding sites has been suggested to be an ultimate factor, and several competitor-based hypotheses have been proposed to explain this pattern. If wintering sites close to the breeding sites are favored, competi
With global politics increasingly fractured, states are rushing to secure critical and strategic mineral supply chains. Each state conceptualizes mineral security differently, driven by a mix of imperatives that range from national development and industrial policy to technological and military dominance. Great power competition pervades all of these issue areas, and that competition may also pose
Objectives: To identify characteristics of older adult emergency department (ED) patients aged ≥65 with suicidal ideation and/or behavior. Methods: A single center retrospective chart review analyzed 392 patients (≥65) with suicidal ideation and/or behavior (2013–2019). Comprehensive full-text searches were used. Subgroup analyses for age and gender were conducted. Results: Depressive disorder was
Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1
Purpose: Some patients with anterior cruciate ligament (ACL) injury initially treated with rehabilitation need ACL reconstruction (ACLR); yet, it is unclear what characterizes these patients. This review aimed to describe predictors for ACLR in patients initially treated with rehabilitation. Methods: A systematic literature search was performed in the Cochrane, Embase, Medline, SportsDiscus and We
The tumour immune microenvironment (TIME) in breast cancer is acknowledged with an increasing role in treatment response and prognosis. With a growing number of immune markers analysed, digital image analysis may facilitate broader TIME understanding, even in single-plex IHC data. To facilitate analyses of the latter an open-source image analysis pipeline, Tissue microarray MArker Quantification (
In Sweden, phosphorus is commonly removed from municipal wastewater treatment by chemical precipitation (CP). Recently, such alternatives as enhanced biological phosphorus removal (EBPR) have garnered interest due to the increased risk of chemical shortage. In this study, a life cycle assessment (LCA) was performed to compare EBPR and CP in three scenarios: 1) baseline – precipitation chemicals av
Background: Given the national shortage of palliative care specialists relative to the need for their services, engaging nonspecialists is important to ensure patients with serious illness have an opportunity to share their goals and values with their providers. Hospital medicine clinicians are well positioned to conduct these conversations given they care for many medically complex patients. Yet,
BACKGROUND: We designed group coaching calls to reinforce communication skill acquisition and Serious Illness Care Program uptake in adult primary care.MEASURES: Percentage of primary care physicians (PCPs) who have documented a serious illness conversation in the electronic health record (EHR) approximately three and six months after the coaching intervention. Participant feedback surveys to bett
Advanced cancer, with its considerable physical symptoms and psychosocial burdens, represents an existential threat and major stressor to patients and their caregivers. In response to such stress, patients and their caregivers use a variety of strategies to manage the disease and related symptoms, such as problem-focused, emotion-focused, meaning-focused, and spiritual/religious coping. The use of
