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A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumo
Methylglyoxal (MG) is a reactive and toxic compound produced in carbohydrate, lipid, and amino acid metabolism. The glyoxalase system is the main detoxifying route for MG and consists of two enzymes, glyoxalase I (GlxI) and glyoxalase II (GlxII). GlxI catalyzes the formation of S-d-lactoylglutathione from hemithioacetal, and GlxII converts this intermediate to d-lactate. A relationship between the
This paper presents a database with the probably most up-to date and reliable consumer price indices for a large sample of European countries since 1870. The database is a compilation but a contribution by going back to original or ignored works. For some Eastern European countries, where CPIs have been missing, new provisional indices are constructed. It critically examines historical CPIs in oft
Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have amajor impact on the quality of life of the affected patients and their partners. Based on the deliberati
Importance: Obsessive-compulsive disorder (OCD) is associated with adverse health-related outcomes. However, pregnancy and neonatal outcomes among women with OCD have been sparsely studied. Objective: To evaluate associations of maternal OCD with pregnancy, delivery, and neonatal outcomes. Design, Setting, and Participants: Two register-based cohort studies in Sweden and British Columbia (BC), Can
Context. β Pictoris is a young nearby system hosting a well-resolved edge-on debris disk, along with at least two exoplanets. It offers key opportunities for carrying out detailed studies of the evolution of young planetary systems and their shaping soon after the end of the planetary formation phase. Aims. We analyzed high-contrast coronagraphic images of this system, obtained in the mid-infrared
Using functional imaging and neural circuit reconstructions, a recent study reveals head direction neurons in the anterior hindbrain of zebrafish that resemble insect head-direction cells to a surprising degree.
Background: Gambling disorder is associated with increased suicidality, especially in women who also are more likely to have psychiatric comorbid disorders and more often have experiences of traumatic life events. Although suicidality is increased and several risk factors have been identified, knowledge of the suicidal process is lacking, especially for women. Aim: To explore the lived experiences
In addition to peripheral neuropathy of various manifestations, diabetes is also associated with central neuropathy. This can manifest as premature cognitive decline, although the role of hyperglycemia in this process remains ambiguous. Notwithstanding that the link between diabetes and cognitive decline was discovered 100 years ago, and has important clinical implications, this co-morbidity remai
This article examines the Norwegian climate fiction television series Okkupert [Occupied](2015–), focusing on the ways in which it reveals the complicity of Nordic subjects in an ecological dystopia. I argue that in illuminating this complicity, the series reimagines the Norwegian national self-conception rooted in a discourse of Norway’s exceptionalist relation to nature. I show how Norway’s gree
Addressing representations of Russia and neighbouring Eastern Europe in post-1989 Nordic cinemas, this ground-breaking volume investigates their hitherto-overlooked transnational dimension. Departing from the dark stereotypes that characterise much of ‘Eastern noir’, the author presents Russia and Eastern Europe as imagined spaces depicted with a surprisingly rich, but previously neglected, cinema
Paper 1Several problems emerge when a paperboard package is modeled by means of the nite element method. One of the issues that one has to deal with is the constitutive model of the paperboard. Paperboard and paper in general areorthotropic materials, which means that constitutive parameters in three orthogonal directions must be determined. Furthermore, the geometry of papersheets makes it dicult
In this paper we understand cities today as commodified spaceswhich must struggle at the intersection of cultural, ideological andhistorical tensions. In order to explore and problematisea contested city brand’s marketing effort, we engage in multiplerounds of in-situ introspective reflections about a racialised city’splace branding material. Based on the two authors’ separate analysesof the same
Paper 1The problem in which a flexible structure interacts with an acoustic fluid is analysed by use of the finite element method. With increasing complexity of the geometry and when increasing the frequency limit is of interest, the number of degrees of freedom needed to describe the system becomes very large. To reduce the coupled system, modal analysis is performed in the structural and in the
Calls for research contribution and demands for original theories have become visibly and audibly louder in review processes over the last two decades. In interpretivist marketing and consumer research, such calls have been accompanied by an emphasis on the importance of theory and on drawing on context when crafting impactful research contributions. By investigating the rhetorical claims made by
Flexitarian and vegetarian diets are of growing interest in France. While the nutritional profiles of individuals with high intakes of plant products are well characterized, exposure to pesticide residues and chemical contaminants are less documented. Moreover, higher consumption of organic products has been associated with higher consumption of plant products. Organic agriculture differs from its
Sustainability is now accounted for in certain food-based dietary guidelines (FBDG). In 2017, the French FBDG were updated to incorporate environmental preservation. We conducted a multi-indicator evaluation of the 2001 and 2017 FBDG, based on data from 28,340 participants in the NutriNet-Santé cohort who completed an organic food frequency questionnaire. Indicators related to nutrition, environme
