Background: Use of tumor necrosis factor inhibitors (TNFi) in patients with a history of cancer remains a clinical dilemma. Objective: To investigate whether TNFi treatment in rheumatoid arthritis (RA) is associated with increased risk for cancer recurrence. Design: Population-based cohort study based on linkage of nationwide registers. Setting: Sweden. Participants: Patients with RA who started T

Background: Several prognostic signatures for early oestrogen receptor-positive (ER+) breast cancer have been established with a 10-year follow-up. We tested the hypothesis that signatures optimised for 0-5-year and 5-10-year follow-up separately are more prognostic than a single signature optimised for 10 years. Methods: Genes previously identified as prognostic or associated with endocrine resis

It is well known that proteinuria following urinary tract obstruction is mainly of a tubular nature. However, it is unknown whether there are also changes in glomerular permeability. In this study, we compared glomerular sieving coefficients (θ) of polydisperse fluorescein isothiocyanate (FITC)-Ficoll 70/400 following a 120-or 180-min unilateral ureteral obstruction (UUO) in anesthetized Sprague-D

Patient-reported outcome (PRO) measures have been used to assess quality of life and health state preferences from the patient's perspective. However, they have not been fully utilized in haemophilia clinical practice and research. A series of meetings were convened to review and document the state of the art in PROs relevant to haemophilia. Experts developed a process for selection of measures an

The influence of boiling and storage on dietary fibre and digestible carbohydrates was investigated in eight different carrot cultivars. The content of total dietary fibre was in the range 252-291 g kg-1 DW and was generally at the higher end for the early cultivars and at the lower end for the late ones. During storage, there was a decrease in the soluble fibre content in all cultivars and genera

The influence of microwave cooking/reheating on dietary fiber in green beans was investigated. The beans were analyzed after blanching and following repeated microwave treatment. Content and composition of dietary fiber as well as molecular weight distribution and viscosity of indigestible water-soluble polysaccharides (WSP) (Mw >1000) were determined. Total fiber content decreased only after the

This article deals with the question as to whether gender equality in labour force participation affects generalized trust. Following the seminal work of Rothstein and Uslaner, a first hypothesis maintains that gender employment equality positively impacts generalized trust. Based on insights from intergroup contact theory and the affect theory of social exchange, a second hypothesis argues that t

In the current discourse it is frequently stated that in the course of European integration and globalisation we witness more intensified and more frequent transactions spanning across national borders. These assumptions relate not only to transactions in the economic sphere or to forms of political co-operation, but to the individual lifeworlds as well. Yet concerning the latter dimension, resear

The article explores the extent to which the German population is involved in transnational networks of personal relationships. It is argued that ongoing processes of globalization have weakened the social cohesion of nation-states and engendered more and more border-crossing transactions. In the paper, key empirical indicators are presented to demonstrate the increased transnational interdependen

The notion of warping the rate of time is explored in the context of differentially flat systems to enable time-optimal motion by convex optimisation. Examples are given with systems configured on the special Euclidean groups SE(2) and SE(3), with and without differential constraints. The proposed method complements classical methods of motion planning, may be used in a real-time context with guar

Context. Spectroscopy across spatially resolved stellar surfaces reveals spectral line profiles free from rotational broadening, whose gradual changes from disk center toward the stellar limb reflect an atmospheric fine structure that is possible to model by 3D hydrodynamics. Aims. Previous studies of photospheric spectral lines across stellar disks exist for the Sun and HD 209458 (G0 V) and are n

IntroductionDuring 2008, the oil price climbed from one peak to the next. Despite the fact that high grain and sugar prices – the main feed stocks for bioethanol plant – are currently causing a slow down in the realisation of bioethanol projects, the interest for renewable fuels is still increasing. In the Nordic countries, Sweden and Finland are leading the development of bioethanol production, w

Artikeln behandlar hur Karl XIV Johan visuellt skapade band med alla skikt av sitt nya lands befolkning genom att förknippa sig med ärorika föregångare i ämbetet. Detta uttrycktes medvetet i porträtt och monument, men även inredningar, arkitektur och ceremonier. Hans son förde vidare denna strategi genom att bygga upp monument över sin far. Detta ingick i ett brett spektrum av traditionella och ny

This paper discusses the relevance of transient events of strong large-scale ocean evaporation (SLOE) for the deuteriumexcess of marine boundary layer vapor d using a theoretical framework that invokes the closure assumption. We argue that during SLOE events, d is essentially determined by the evaporation flux signature. Distinct high d during SLOE with global-mean values in the range of 12‰-23‰ d

The contents of low-molecular-weight carbohydrates (LMWC; sorbitol, glucose, fructose and sucrose), starch, dietary fibre and organic acids were determined in seven apple cultivars at the start and end of the consumption interval. The cultivars included were Summered, Aroma, Ingrid Marie, Cox Orange, Mutzu, Belle de Boskoop and Jonagold. The total content of LMWG ranged between 615 and 716 g kg-1