The fact that deep learning based algorithms used for digital pathology tend to overfit to the site of the training data is well-known. Since an algorithm that does not generalize is not very useful, we have in this work studied how different data augmentation techniques can reduce this problem but also how data from different sites can be normalized to each other. For both of these approaches we

Non-invasive characterization of brain structure has been made possible by the introduction of magnetic resonance imaging (MRI). Graph modeling of structural connectivity has been useful, but is often limited to defining nodes as regions from a brain atlas. Here, we propose two methods for encoding structural connectivity in a huge brain graph at the voxel-level resolution (i.e., 850'000 voxels) b

Knowledge of the atomic structure of biomolecules, such as proteins, is paramount to understanding their function and interactions in the human body. For example, knowledge of the atomic structure of a target protein is crucial for developing drugs that bind strongly to it and thus help cure diverse diseases.Macromolecular crystallography is the forefront method for determining the atomic structur

Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumor

Objectives: To assess potential correlations between intraepidermal nerve fiber densities (IENFD), graded with light microscopy, and clinical measures of peripheral neuropathy in elderly male subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM), respectively. Materials and methods: IENFD was assessed in thin sections of skin biopsies from dista

Background: An infant’s development is closely linked to the relationship they have with their parents. Parenting stress, affective disorder, and an upbringing with substance-abusing parents can affect parenting quality and increase the risk of children developing behavioral, mental and social problems. The overall aim of the study was to investigate how parents of children attending an outpatient

The main current methods for controlling American Foulbrood (AFB) in honeybees, caused by the bacterial pathogen Paenibacillus larvae, are enforced incineration or prophylactic antibiotic treatment, neither of which is fully satisfactory. This has led to an increased interest in the natural relationships between the pathogenic and mutualistic microorganisms of the honeybee microbiome, in particula

This study uses a discontinuity in the Swedish tertiary eligibility requirement to estimate the probability of enrolling in tertiary education, and the payoff thereof. Regression discontinuity results, show that achieving tertiary eligibility in upper-secondary education, increases the probability of enrolling in tertiary education by around 10–15 and 7 percentage points for students who enrolled

Background: Continuous EEG-monitoring (cEEG) in the ICU is recommended to assess prognosis and detect seizures after cardiac arrest but implementation is often limited by the lack of EEG-technicians and experts. The aim of the study was to assess ICU physicians ability to perform preliminary interpretations of a simplified cEEG in the post cardiac arrest setting. Methods: Five ICU physicians recei

Background: The majority of patients with incurable esophageal adenocarcinoma suffer from dysphagia. We assessed a novel treatment strategy with initial short-course radiotherapy followed by chemotherapy with the primary aim to achieve long-term relief of dysphagia. Methods: This phase II trial included treatment-naîve patients with dysphagia due to esophageal adenocarcinoma not eligible for curat

Aim: To investigate the relationships between pain in the lower extremities and back, and spasticity, bone/joint complications and mobility. Methods: Retrospective population-based registry study. Participants (N = 3256) with cerebral palsy (CP), 2.5-16 years of age, participating in the Swedish Cerebral Palsy Follow-up Program were included. Spasticity was measured using scissoring and the Modifi

Elder law is often approached in terms of a 'body' of law. In this article, I argue for a contextualised and externalised perspective on the ageing individual as the subject of elder law. Elder law relates to the implications of law as an institutionalisation of society seen through the lens of older persons. The aged subject is a contested and differentiated social construct to be studied in rela

Caregivers report experiences of stress and burden that can affect their health negatively. Web-based mindfulness interventions have shown beneficial health effects in clinical and non-clinical populations, including caregivers. The study’s aim was to explore the experiences of a web-based mindfulness program, including motivation and challenges to use, in caregivers of a person with somatic illne

We study membership in Lipschitz classes (Formula presented.) for a class of α-harmonic functions in the open unit disc (Formula presented.) in the complex plane. From earlier work by Olofsson and Wittsten we know that such an α-harmonic function u is the α-harmonic Poisson integral (Formula presented.) of its boundary value function f on the unit circle (Formula presented.). We determine when the

Purpose: Previous literature on the commercialisation of the audit profession has focused on the coercive force of macro-institutional structures. The purpose of this paper is to focus on the agency of individual auditors and examine their active construction of the commercial self in a Big Four audit firm in China. Design/methodology/approach: This paper applied a qualitative research approach to

The δ13C chemostratigraphy of five of the seven Ordovician global stages has been published previously but no such data have been available from the Floian GSSP and most of the Sandbian GSSP in Sweden. This lack of information has now been remedied by isotope data obtained from series of closely spaced shale samples collected from the Floian stratotype at Diabasbrottet in Västergötland and the San

Over the past 40 years, implementation of public policy has been developed into a mature but heterogenous field of research. Despite much attention paid to the context in which implementation occurs, studies thus far has only to a limited extent been concerned with how major socio-technological transitions affect the conditions for implementing policy. As societies experience major socio-technolog

Objective: To examine cause-specific mortality beyond cardiovascular diseases (CVDs) in patients with gout compared to the general population. Methods: We included all residents of Skåne (Sweden) age ≥18 years in the year 2002. Using the Skåne Healthcare Register, we identified subjects with a new diagnosis of gout (2003–2013) and matched each person with gout with 10 comparators free of gout, by

Background: Alcohol use disorders are a major but often unrecognized health problem. Alcohol markers can therefore be of great value for diagnosis, follow-up, and treatment evaluation. Phosphatidylethanol in blood (B-PEth) is an alcohol biomarker with higher clinical sensitivity and specificity than commonly used alcohol markers but has shown a considerable interindividual variation in relation to