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LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. Therefore it is important to investigate the role of LTD4 signalling in cancer development and progression. In this thesis I show that there is an end

Thermal performance analysis and measurements of the prototype cryomodules of European XFEL accelerator-Part II

Three accelerator prototype cryomodules (CMs) for the European XFEL have been produced, assembled and tested at DESY in a wide international collaboration. The heat load budget is a key element in the qualification of these CMs. We describe in this paper the measurements performed in the Cryomodule test bench (CMTB) to evaluate the thermal performances of the three prototype CMs. We present at fir

Advancing QCD-based calculations of energy loss

We give a brief overview of the basics and current developments of QCD-based calculations of radiative processes in medium. We put an emphasis on the underlying physics concepts and discuss the theoretical uncertainties inherently associated with the fundamental parameters to be extracted from data. An important area of development is the study of the single-gluon emission in medium. Moreover, est

No evidence of locus heterogeneity in familial microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome.

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome (MCLMR) is a rare autosomal dominant disorder with variable expressivity. It is characterized by mild-to-severe microcephaly, often associated with intellectual disability, ocular defects and lymphedema. It can be sporadic or inherited. Eighty-seven patients have been described to carry a mutation in KIF11,

Semiblind Spectrum Balancing for DSL

Digital subscriber lines (DSLs) technology is vastly used for high-speed data transmission. Crosstalk is one of the main problems in DSL. The research community has done extensive work on how to optimize spectrum allocation across DSL frequencies and mitigate crosstalk, a subject that has been called dynamic spectrum management (DSM). This text presents a novel DSM solution, referred to as semibli

A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients

The cyclopentanone and cyclopentenone group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.002% to 15.16% in hydroalcoholic products; systemic exposures vary from 0.0003 to 0.7122 mg/kg/day. The cyclopentanones and cyclopentenones had a low order of acute toxicity and no signif

Economic stress in childhood and adulthood, and self-rated health: a population based study concerning risk accumulation, critical period and social mobility

Background: Research in recent decades increasingly indicates the importance of conditions in early life for health in adulthood. Only few studies have investigated socioeconomic conditions in both childhood and adulthood in relation to health testing the risk accumulation, critical period, and social mobility hypotheses within the same setting. This study investigates the associations between eco

Are You Biting Off More Than You Can Chew? A Case Study on Causes and Effects of Overscoping in Large-Scale Software Engineering

Context: Scope management is a core part of software release management and often a key factor in releasing successful software products to the market. In a market-driven case, when only a few requirements are known a priori, the risk of overscoping may increase. Objective: This paper reports on findings from a case study aimed at understanding overscoping in large-scale, market-driven software dev

The Effect of ACACB cis-Variants on Gene Expression and Metabolic Traits

Background: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine wheth

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still a daunting task to prioritize single nucleotide polymorphisms (SNPs) from GWAS for further replication in different population. Several recent studies have shown that genetic var

A functional variant in the CFI gene confers a high risk of age-related macular degeneration

Up to half of the heritability of age-related macular degeneration (AMD) is explained by common variants(1-5). Here, we report the identification of a rare, highly penetrant missense mutation in CFI encoding a p.Gly119Arg substitution that confers high risk of AMD (P = 3.79 x 10(-6); odds ratio (OR) = 22.20, 95% confidence interval (CI) = 2.98-164.49). Plasma and sera from cases carrying the p.Gly

Impact of Lifestyle, Hormones, and Genes on Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor i Sverige. Årligen drabbas 7000 kvinnor i Sverige och cirka 1500 kvinnor dör av sin sjukdom. Bröstcancer uppkommer genom ett samspel mellan livsstil, miljö och gener. En kvinna som har en förstagradssläkting (t.ex. syster, mor) med bröstcancer har ungefär dubbelt så stor risk att drabbas av bröstcancer jämfört med eApproximately 7000 women are diagnosed and 1500 women die from breast cancer in Sweden every year. The aim of this thesis was to study the interplay of polymorphisms, hormone levels, lifestyle, and the use of concomitant medication in relation to risk and prognosis in two cohorts: one composed of young healthy women from high-risk breast cancer families and the other of breast cancer patients fro

The ACS survey of Galactic globular clusters XII. Photometric binaries along the main sequence

Context. The fraction of binary stars is an important ingredient to interpret globular cluster dynamical evolution and their stellar population. Aims. We investigate the properties of main-sequence binaries measured in a uniform photometric sample of 59 Galactic globular clusters that were observed by HST WFC/ACS as a part of the Globular Cluster Treasury project. Methods. We measured the fraction

A high-pressure homogenization emulsification model—Improved emulsifier transport and hydrodynamic coupling

The high-pressure homogenizer emulsification modelling framework by Håkansson et al. (2009a,Chemical Engineering Science 64, 2915–2925; 2009b. Food Hydrocolloids 23, 1177–1183), is further developed in this study. The model, including the simultaneous fragmentation of drops, coalescence of drops and kinetic adsorption of macromolecular emulsifiers, is improved with regard to two points.First, the

Measurement of D*(+/-) meson production and determination of F-2(c(c)over-bar) at low Q(2) in deep-inelastic scattering at HERA

Inclusive production of D* mesons in deep-inelastic ep scattering at HERA is studied in the range 5 < Q(2) < 100 GeV2 of the photon virtuality and 0.02 < y < 0.7 of the inelasticity of the scattering process. The observed phase space for the D* meson is (pT) (D*) > 1.25 GeV and |eta( D*)| < 1.8. The data sample corresponds to an integrated luminosity of 348 pb(-1) collected with the H1 detector. S