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Ukraine: Don’t write off the international order – read and rewrite it
Resistance to Russia’s aggression is being shaped by how decentralised and data-centric global rules have become.
Laparoscopic hernia surgery in Sweden 2010 to 2020—scientifically highlights from the national Swedish Hernia Register
The Swedish Hernia Register (SHR) is a national quality register with more than 350,000 prospectively registered groin hernia repairs. Studies from the SHR have addressed important and clinically relevant issues within the field of laparoscopic groin hernia surgery and the aim of this paper is to present five of the most innovative patient-oriented publications including analysis of laparoscopic h
A Summary : Portraying the Legal Culture and the European Human Rights Culture of the European Court of Human Rights and the European Court of Justice through Interviews
To show the impact of interviews for European legal studies, this article summarizes the earlier findings of two books, the first by Arold on the legal culture of the European Court of Human Rights (ECtHR), and the second by Arold Lorenz, Groussot and Petursson on the legal culture of the European Court of Justice (CJEU) and European human rights culture. In doing so, this article draws a portrait
Optimum dog-leg angle for mass and bearing force optimization of multistage gear reduction
This paper describes a method to minimize bearing forces as well as bearing and housing mass for a multistage gear reduction. This is done by finding the optimum dog-leg angles for the stages while leaving other aspects of the design unaltered. The optimization is demonstrated first for spur gears, and then for helical gears typically used in electric vehicles. A numerical example shows how bearin
The Military in the Time of COVID-19: Versatile, Vulnerable, and Vindicating
Prevalence of alcohol consumption in most at-risk groups in Iran : a systematic review and meta-analysis
Introduction: Many studies have assessed the prevalence of alcohol consumption in Iran. In this study, we investigated the prevalence of alcohol consumption in different groups. Material and Methods: We searched international and databases including PubMed, Web of Science, Scopus and we searched two main Farsi-language index databases including Scientific Information Database (SID) and the Irandoc
The role of RNA-binding proteins in the processing of mRNAs produced by carcinogenic papillomaviruses
Human papillomaviruses (HPV) are epitheliotropic DNA tumor viruses that are prevalent in the human population. A subset of the HPVs termed high-risk HPVs (HR-HPVs) are causative agents of anogenital cancers and head-and-neck cancers. Cancer is the result of persistent high-risk HPV infections that have not been cleared by the immune system of the host. These infections are characterized by dysregu
Limonene and linalool hydroperoxides review : Pros and cons for routine patch testing
Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydrop
Renovisceral Coverage in Fenestrated Aortic Repair : The Only Way is Up?
A Copernican response : To know what we know
Response to : ‘The relationship between preoperative sleep quality and adverse pain outcomes is still unclear—A comment on Bjurström et al.’
Emerging industries : institutions, legitimacy and system-level agency
Economic geographers have studied emerging industries in regions from various perspectives, such as life cycle, evolutionary economic geography and systemic approaches. However, so far they have insufficiently conceptualized the effects of institutional structures on new industry emergence. This special issue on ‘Emerging Industries: Institutions, Legitimacy and System Building’ therefore shows re
Latitudinal patterns of light and heavy organic matter fractions in arid and semi-arid soils
Semi-arid and arid ecosystems are important for the global C cycle. Despite this, it remains unclear how organic matter fractions vary across latitudinal gradients, and what drives this variation, in dry ecosystems. In this study, we sampled soils from 100 sites across a latitudinal gradient in the dry valleys of southwestern China to explore the latitudinal patterns of light fraction organic matt
Cost Effectiveness of the Use of Prophylactic Mesh To Prevent Parastomal Hernia After Urinary Diversion with an Ileal Conduit
Background: Prophylactic lightweight mesh in the sublay position reduced the cumulative incidence of parastomal hernia (PSH) after cystectomy with ileal conduit diversion in a randomised controlled trial.Objective: To investigate whether the use of prophylactic mesh is cost-effective in comparison to no mesh from the health care provider perspective.Design setting and participants: Data on health
Quantitative trait loci, G×E and G×G for glycemic traits : response to metformin and placebo in the Diabetes Prevention Program (DPP)
The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we screened markers for patterns indicative of interactions (relationship loci [rQTL] and variance heterogeneity loci [vQTL]). rQTL exist when the correlation between multiple traits varies by genotype and vQTL occur when the variance of a trait
Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study
BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct er
Information and communication technology in home-based rehabilitation–a discussion of possibilities and challenges
Background: Information and communication technology (ICT) has been proven to have effect in terms of providing alternative ways to deliver rehabilitation services. The intention with this paper is to serve as a foundation for discussions regarding the future development, design, and delivery of home-based rehabilitation, including ICT. Aim: To reflect on and discuss the possibilities and challeng
Automated Bone Scan Index to Optimize Prostate Cancer Working Group Radiographic Progression Criteria for Men With Metastatic Castration-Resistant Prostate Cancer
Introduction: Radiographic progression-free survival (rPFS) by Prostate Cancer Working Group (PCWG) criteria is a radiographic endpoint. The automated bone scan index (aBSI) quantifies osseous disease burden on bone scintigraphy as a percentage of total skeletal weight. Using the aBSI, we sought to quantify increase in tumor burden represented by PCWG progression criteria, and to determine the int
Quality of life in a large multinational haemophilia B cohort (The B-Natural study) – Unmet needs remain
Introduction: The B-Natural study is a multicentre, multinational, observational study of haemophilia B (HB) designed to increase understanding of clinical manifestations, treatment and quality of life (QoL). Aim: To characterise and compare QoL in HB across disease severity groups and individuals with inhibitors to identify gaps in treatment. Methods: A total of 224 individuals from 107 families