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Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated

Hijacking Banksy : a discussion about ethical research practice within the street art world

Taking as its point of departure an article entitled "Tagging Banksy: using geographic profiling to investigate a modern art mystery" which was published in Journal of Spatial Science in March 2016, the present keynote paper aims to open up a discussion about ethical research practice within the street art world and the implications for street art researchers when such practice is violated.

Regional market integration in Italy during the unification (1832-1882)

The 19th century was a period of great transformations for Italy. Political unification was achieved in 1861 while economic unification was still far off. Ever since, Italian industrialization has been unbalanced, as the pre-existing gap between Northern and Southern economic development has widened. In this context, the creation of the Italian national market has been a highly debated topic. Orig

The Industrial Labor Force of Italy's Provinces: Estimates from the Population Censuses, 1871-1911

This paper presents statistical reconstructions of the industrial labor force in post-Unification Italy. The estimates are based on the population censuses taken in 1871, 1881, 1901, and 1911. The figures are presented for each of Italy's 69 provinces, separately by gender. Industry, as is customary in the literature, is defined so to include four major components: mining, manufacturing, construct

Business Fluctuations in Imperial Austria's Regions, 1867-1913: New Evidence

This paper presents annual estimates of total and per-capita GDP at 1910 prices for the regions of Imperial Austria from the origin of the Dual Monarchy (1867) to the eve of WWI (1913). The time paths of regional GDP are estimated from the yield of the tax on the transfer of real and financial property which is itself very highly correlated with the Schulze (2007) estimates of regional GDP for cen

Familial risks of glomerulonephritis : a nationwide family study in Sweden

Objective: Familial risks of glomerulonephritis (acute, chronic and unspecified glomerulonephritis) have not been studied. This study aims to determine the familial risks of glomerulonephritis. Methods: Individuals born from1932 onwards diagnosed with glomerulonephritis (acute [n = 7011], chronic [n = 10,242] and unspecified glomerulonephritis [n = 5762]) were included. The familial risk (Standard