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Structure and ion-release mechanism of P IB-4-type ATPases

Abstract Transition metals, such as zinc, are essential micronutrients in all organisms, but alsohighly toxic in excessive amounts. Heavy-metal transporting P-type (PIB) ATPases are crucial forhomeostasis, conferring cellular detoxification and redistribution through transport of these ionsacross cellular membranes. No structural information is available for the PIB-4-ATPases, the subclasswith the

Swedish Foreign Policy Feminisms : Women, Capitalism and Social Democracy

This article outlines the historical distinctiveness of the feminist foreign policy (FFP) Sweden has pursued since 2014. To highlight the particularity of the current FFP, we make use of two methodological moves: de-framing and counterpoint. De-framing helps us highlight the importance for the current FFP of a moment in the beginning of the 1990s, when a feminism naturalising capitalist arrangemen

Confocal imaging dataset to assess endothelial cell orientation during extreme glucose conditions

Confocal microscopy offers a mean to extract quantitative data on spatially confined subcellular structures. Here, we provide an imaging dataset of confocal z-stacks on endothelial cells spatially confined on lines with different widths, visualizing the nucleus, F-actin, and zonula occludens-1 (ZO-1), as well as the lines. This dataset also includes confocal images of spatially confined endothelia

Bayesian modeling of item heterogeneity in dichotomous recognition memory data and prospects for computerized adaptive testing

Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests. Here we propose to employ a General Condorcet Model for Recognition (GCMR) in order to estimate ability, response bias and item difficulty in dichotomous recognition memory tasks.

Does the 5–2-1 criteria identify patients with advanced Parkinson's disease? Real-world screening accuracy and burden of 5–2-1-positive patients in 7 countries

Background: The burden of Parkinson’s disease (PD) worsens with disease progression. However, the lack of objective and uniform disease classification challenges our understanding of the incremental burden in patients with advanced Parkinson’s disease (APD) and suboptimal medication control. The 5–2-1 criteria was proposed by clinical consensus to identify patients with advancing PD. Our objective

The effects of virtual reality training in stroke and Parkinson’s disease rehabilitation : a systematic review and a perspective on usability

Background: Virtual Reality (VR) training is emerging in the neurorehabilitation field. Technological advancement is often faster than clinical implementation. Previous reviews stressed the study design and methodological weaknesses of research in the field of VR for neurorehabilitation. Clinically relevant conclusions on implementation in particular patient groups are needed. The aim was to updat

Still engaged – healthcare staff’s engagement when introducing a new eHealth solution for wound management : a qualitative study

Background: eHealth solutions have often been considered favourable for improved effectiveness and quality in healthcare services for wound management. Staff engagement related to organisational changes is a key factor for successful development and implementation of a new eHealth solution, like a digital decision support systems (DDSS). It is essential to understand the engagement process in term

Gränsdragning och ansvarsförskjutning i dataspelsbranschen

En av de snabbast växande kreativa branscherna i Sverige är dataspelsbranschen. En konsekvens av den snabba tillväxten är att branschen upplever stora utmaningar med sin kompetensförsörjning. I branschen finns därför en risk att arbetsbelastningen blir hög och att rimliga arbetsvillkor frångås. I Nordamerika och Storbritannien där branschen etablerades tidigare än i Sverige har ett antal studier g

Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures : The MORGAM prospective cohort project

To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without establish

Tactile friction of topical creams and emulsions : Friction measurements on excised skin and VitroSkin® using ForceBoard™

Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfac

Overtourism, residents and Iranian rural villages : Voices from a developing country

Differing from much of the research on overtourism, which has concentrated on urban tourist destinations, this exploratory study investigates the attitudes of rural communities toward over-visitation. Face-to-face interviews with 63 respondents in three of the most visited Iranian villages reveal that tourism creates social, psychological and health problems for residents. Findings indicate that l

Striving for Close Resemblance or Creative Improvements : On Painted Copies and Workshop Replicas from the Sixteenth and Seventeenth Century in Swedish Art History

This study examines painted copies from the sixteenth and seventeenth centuries to gain a richer understanding of the phenomenon of copies and of copying as a common artistic practice. The study findings suggest that copies painted in Sweden in the seventeenth century were, in general, free copies. In that century, the Swedish economy was booming, and a semi-regulated art market had developed, and

Ignition and combustion behavior of single micron-sized iron particle in hot gas flow

This work investigated the ignition and combustion process of single micron-sized iron particles in the hot gas flow of burned methane-oxygen-nitrogen mixture. The particle emission intensity was recorded by a high-speed camera in different flame conditions. Particle temperature was derived through two-color pyrometry method employing an ICCD camera equipped with a stereoscope. Based on scanning e

Structure and scalar correlation of ammonia/air turbulent premixed flames in the distributed reaction zone regime

Instantaneous structures of turbulent premixed ammonia/air flames on a piloted jet burner were investigated using simultaneous planar laser-induced fluorescence (PLIF) and Rayleigh thermometry measurements. Two-dimensional spatial distributions of temperature were simultaneously measured with those of the NH radical and the NO pollutant, respectively. Experiments were conducted for stoichiometric