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Comparing phase sensitive detection and Fourier analysis of modulation excitation spectroscopy data exemplified by Ambient Pressure X-ray Photoelectron Spectroscopy

Dynamic processes in catalysis are gaining increased attention and could very well be one of the next frontiers in surface science. One way to study such processes is to induce chemical changes on the surface for example by periodically adjusting the (electro)chemical potential in situ and identify the resulting spectral changes. Often this is referred to as Modulation Excitation Spectroscopy (MES

Organizing employee-driven innovation (EDI) through game-based formats : Understanding participation

The awareness of employee-driven innovation (EDI) and its strategic relevance to corporate development has recently increased. The implications of EDI are vigorously discussed in terms of inclusive approaches; particularly focussing on how managerial structures can enable employee participation. This paper focusses on game-based formats to enhance such participation and explores what participation

Decreasing incidence of celiac disease in Southern Sweden

Background: The incidence of celiac disease (CD) has increased rapidly in the late 20th and early 21st centuries, but there are recent reports of rates levelling off in countries with a high prevalence. The aim of this study was to investigate current trends in CD in southern Sweden. Patients and methods: Children and adults diagnosed with CD by biopsy or serology in the region of Skåne, southern

Measurements of the laminar burning velocities of 1,2-butadiene : A comparative study

1,2-butadiene (1,2-C4H6) is one of four C4H6 isomers that could appear during pyrolysis and oxidation of heavier hydrocarbons and/or contribute to the formation of aromatic species in flames. However, it is seldom included in detailed kinetic mechanisms due to a lack of studies of its combustion characteristics. In this work, laminar burning velocities (LBV) of 1,2-butadiene flames have been measu

The potential for evolutionary rescue in an Arctic seashore plant threatened by climate change

The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered Arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to warming climate. We evaluate the potential of these populations to evolve to facilitate sur

Microbial acidification by N, S, Fe and Mn oxidation as a key mechanism for deterioration of subsea tunnel sprayed concrete

The deterioration of fibre-reinforced sprayed concrete was studied in the Oslofjord subsea tunnel (Norway). At sites with intrusion of saline groundwater resulting in biofilm growth, the concrete exhibited significant concrete deterioration and steel fibre corrosion. Using amplicon sequencing and shotgun metagenomics, the microbial taxa and surveyed potential microbial mechanisms of concrete degra

Quantitative mass spectrometry analysis of the injured proximal and distal human digital nerve ends

Introduction: Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, focusing on differences in protein expression between the proximal and distal nerve ends. Methods: A total of 26 human injured

Pressure enabled organic reactions via confinement between layers of 2D materials

Confinement of reactants within nanoscale spaces of low-dimensional materials has been shown to provide reorientation of strained reactants or stabilization of unstable reactants for synthesis of molecules and tuning of chemical reactivity. While few studies have reported chemistry within zero-dimensional pores and one-dimensional nanotubes, organic reactions in confined spaces between two-dimensi

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

Poly(ADP-ribose) polymerases (PARPs) are key enzymes in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, and suffer from poor selectivity. PARP14 has recently emerged as a potential therapeutic target, but its inhibitor development has trailed behind. Herein, we describe a small molecule microarray-based strategy for high-throughput sy

House Flora Valerie

Architecture and space in the scale of a family house can be about rounded shapes interplaying with straight lines and light. In today’s newly built houses in Sweden I sense a lack of variety in combinations of these elements. This project therefore aims to experiment with rounded shapes and straight lines together with light. A collection of the explorations act as the base to draw a house. A vil

PARP inhibitors : polypharmacology versus selective inhibition

Inhibition of ADP-ribosyltransferases with diphtheria toxin homology (ARTD), widely known as the poly(ADP-ribose) polymerase (PARP) family, is a strategy under development for treatment of various conditions, including cancers and ischemia. Here, we give a brief summary of ARTD enzyme functions and the implications for their potential as therapeutic targets. We present an overview of the PARP inhi

Infant urinary tract infection in Sweden — A national study of current diagnostic procedures, imaging and treatment

Background: Urinary tract infection (UTI) in infants is a common, potentially life-threatening bacterial infection, and must be managed carefully through the entire chain of care from diagnosis, choice of treatment, follow-up and risk stratification of future complications. This Swedish nationwide study of infant UTI was conducted to evaluate the current management of infant UTI, yield of investig

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facili

The Degree of Self-Sufficiency Among Native Swedes and Immigrants : Over Time, Life Cycle and Depending on Time in Sweden

Social exclusion and individuals’ self-sufficiency have been on the public agenda in Sweden recently. One reason is the large influx of immigrants to Sweden in 2016. This paper aims to measure self-sufficiency over time, across the life cycle, depending on geographical origin, and time spent in Sweden to provide information about how self-sufficiency has developed over time and across the life cyc

More dads at home, more girls in maths-intensive studies? Evidence from a parental leave reform

Evidence suggests that separate spheres gender norms discourage girls from maths. We therefore examine a policy that counteracts such norms among parents, and investigate whether it increases girls' participation in maths-intensive studies. Specifically, we examine a parental leave reform that reserved one month of leave for fathers, and estimate its effect on children's study choices. We find tha