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Design and characterization of matrix metalloproteinase-responsive hydrogels for the treatment of inflammatory skin diseases

Enzyme-responsive hydrogels, formed by step growth photopolymerization of biscysteine peptide linkers with alkene functionalized polyethylene glycol, provide interesting opportunities as biomaterials and drug delivery systems. In this study, we developed stimuli-responsive, specific, and cytocompatible hydrogels for delivery of anti-inflammatory drugs for the treatment of inflammatory skin disease

Incidence and burden of illness at the Tokyo 2020 Paralympic Games held during the COVID-19 pandemic : a prospective cohort study of 66 045 athlete days

Objective To describe the incidence and burden of illness at the Tokyo 2020 Paralympic Games, which was organised with strict COVID-19 countermeasures. Methods Daily illnesses were recorded via the web-based injury and illness surveillance system (teams with their own medical staff; n=81), and local polyclinic services (teams without their own medical staff; n=81). Illness proportion, incidence an

Characterization of high Arabinoxylan oat lines identified from a mutagenized oat population

Oat (Avena sativa) is a nutritionally important cereal crop that is rich in health-promoting dietary fibers, favorable proteins and polar lipids. In this work, ca. 500 random lines of a mutagenized oat population of high genetic variation were screened for arabinoxylan (AX) content. This identified lines with up to 60% higher AX levels in flour from whole seed and up to 100% higher in flour from d

Single-Standard Quantification Strategy for Lignin Dimers by Supercritical Fluid Chromatography with Charged Aerosol Detection

The increased interest in utilizing lignin as a feedstock to produce various aromatic compounds requires advanced chemical analysis methods to provide qualitative and quantitative characterization of lignin samples along different technology streamlines. However, due to the lack of commercially available chemical standards, routine quantification of industrially relevant lignin oligomers in comple

Cosolvent Dimethyl Sulfoxide Influences Protein-Ligand Binding Kinetics via Solvent Viscosity Effects : Revealing the Success Rate of Complex Formation Following Diffusive Protein-Ligand Encounter

Protein-ligand-exchange kinetics determines the duration of biochemical signals and consequently plays an important role in drug design. Binding studies commonly require solubilization of designed ligands in solvents such as dimethyl sulfoxide (DMSO), resulting in residual amounts of DMSO following titration of solubilized ligands into aqueous protein samples. Therefore, it is critical to establis

The effects of station density in geostatistical prediction of air temperatures in Sweden : A comparison of two interpolation techniques

High fidelity gridded temperature datasets are difficult to obtain for areas with sparse coverage of meteorological stations given that sparsity of stations is known to introduce uncertainty in the interpolation of climatic variables generally. Inspired by their potential for optimal results especially for small sample datasets, we assessed and compared the accuracy of interpolation results of Emp

Nöden har ingen lag. Om demokratins överlevnad i en ’akut nödsituation’ : En reflektion över Sverige 2015

Allt våldsammare deportationer. Fler oskyldiga människor i fängsligt förvar. Fler svårt sjuka barn som skickas till länder där det är högst osäkert om de kan få vård. Ett stigande antal föräldrar som tar med sig sina barn på sjöodugliga båtar över medelhavet för att undvika mångårig separation. En växande mängd ungdomar som lever ett liv i papperslöshetens skuggsamhälle. Detta är några sannolika f

“Pushed out in limbo – The every-day decision-making about ‘practical impediments to enforcement’ in the Swedish management of return migration”

This article presents a study of the contradiction between the rhetoric of return, stressing that rejected asylum seekers should leave the country, and the reality of how migrants end up as legally stranded, in Sweden. Through a qualitative analysis of; 25 decisions by the Swedish Migration Agency, an internal quality report about the legal application, and the documentation in two complete indivi

The Best Interests of the Child Principle in Swedish Asylum Cases : The Marginalization of Children’s Rights

This article is based on a two-year research project, ‘The Best Interests of the Child – From Words to Deeds’. The aim of the article is to present and highlight findings on the discrepancy between the policy of the ‘best interests’ principle and its implementation in the asylum application procedures at the Swedish Migration Board. There is a clear ambition to implement the principle of the best