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Solving simple problems can quickly grow in complexity as more and more re- quirements are added over time. Parking fee’s are no exception to this as reg- ulations, special exceptions and many other factors contribute to create quite complicated fees. This complexity can make it quite difficult for the average person to model a parking-zone in the way they have to. This thesis discusses the nature
The regulation of RNAPII levels - The RNA-polymerase II (RNAPII) controls transcription. But who controls the RNAPII? Every cell in our body depends on a process called transcription, which turns genetic instructions into messages (mRNA) that can be used to make proteins. This essential job is carried out by a molecular machine known as RNA polymerase II (RNAPII). While many studies have investig
In vitro airway epithelial models play a crucial role in respiratory research, particularly for studying barrier function, drug delivery, and host-pathogen interactions. This thesis aimed to characterize electrospun polycaprolactone (e-PCL) in a 96-well plate format as a potential platform for supporting the attachment, proliferation, and differentiation of human airway epithelial cells (Calu-3) u
From green to pale yellow: Genetics of barley chlorophyll deficiency. Barley (Hordeum vulgare L.) is the fourth-largest grain crop in the world, making it one of the most economically important cereals. Today, it is mainly used in both animal feed and brewing. Because barley grows in many different environments and has been cultivated for thousands of years, it has also become an important model
Hur kan cancerbehandling öka risken för hjärt- och kärlsjukdomar? PD1-inhibitorer är en revolutionerande, ny typ av cancerbehandling som gör immunförsvaret starkare och ihärdigare i kampen mot tumörer. Tyvärr kan denna behandling leda till immunaktivering mot kroppens egna organ, till exempel hjärtat och kärlväggen. PD1-inhibitorer har visat sig öka risken för dessa sjukdomar markant, bland annatAtherosclerosis, the formation of inflammatory plaques in the arterial walls, is the most common underlying cause behind cardiovascular disease (CVD). The risk of atherosclerosis has been shown to increase following immune checkpoint inhibitor therapies such as anti-PD1. Anti-PD1 therapy has revolutionized cancer treatment as it blocks the immune checkpoint receptor PD1, preventing T cell exhausti
Deciphering where genes are expressed within the complex architecture of cells and tissues requires advanced spatial transcriptomics techniques. This study focuses on Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH), a technique for spatial transcriptomic. The MERFISH experiment involves probes binding to specific RNA-targeted sequences within fixed cells and tissues. I develo
GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo
This thesis views Sankt Lars begravningsplats (cemetery) as a deathscape where histories of institutionalization, social exclusion, and neoliberal expansion are spatially materialized in the cemetery’s ecology. Tied to the former Sankt Lars asylum on the margins of Lund, Sweden, the cemetery embodies the intersections of human and nonhuman forces where ecological transformations intertwine with cu
Lon Fuller famously argued that polycentric issues are not readily amenable to binary and adversarial forms of adjudication. When it comes to resource allocations involving various interested parties, binary polemical forms of decision making may fail to capture the polycentric nature of the dispute, namely the fact that an advantage conferred to one party invariably involves (detrimentally) affec
Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin
Patients with chronic lymphocytic leukemia (CLL) have an impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence 5 years after pneumococcal vaccination and response to revaccination. Seventy-four CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysac
This thesis examines how parody and satire are used in contemporary Americananimated television series. Through critical textual analysis, five television shows are examined. These are Archer, BoJack Horseman, My Little Pony: Friendship is Magic, Rick and Morty, and South Park. The study offers theoretical background and discussion on key concepts like parody, satire, comedy, animation, television
In an era where online interactions increasingly shape social dynamics, the pervasive issue of cyberbullying poses a significant threat to the well-being of individuals, particularly among vulnerable groups. Despite extensive research on text-based cyberbullying detection, the rise of visual content on social media platforms necessitates new approaches to address cyberbullying using images. This d
Vilken roll spelar beprövad erfarenhet i socialtjänstens beslutsfattande? I det här kapitlet undersöks hur socialsekreterare inom områdena barn och unga samt vuxna med beroendeproblematik använder och delar kunskap i en komplex vardag präglad av krav på rättssäkerhet, evidens och effektivitet. Genom fokusgruppsintervjuer synliggörs det kollegiala lärandets betydelse och hur erfarenhetsbaserad kuns
Background: Ex-vivo perfusion of donor hearts is gaining importance in minimizing ischemia-reperfusion injury during heart transplantation. The Non-Ischemic Heart Preservation (NIHP) device, developed in 2016, has shown promising results in pilot studies. This study aims to compare the mid-term follow-up outcomes of NIHP with traditional Static Cold Storage (SCS) in heart transplantation. Methods:
We study the first-order phase transitions and the emerging stochastic gravitational wave spectrum in a minimal leptoquark extension of the Standard Model that explains active neutrino oscillation data, while satisfying current flavor physics constraints. This model exhibits diverse phase transition patterns, including color symmetry-breaking scenarios in the early Universe. Strong correlations be
