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The effect of temperature and moisture on lag phase length of bacterial growth in soil after substrate addition

Microorganisms in soil are commonly limited by available substrate, and removing the limitation will increase activity and growth, with predictable dynamics in growth. The initial phase with a lag period (λ) will usually be followed by exponential growth (also called log phase, with growth rate μ). These two growth phases may be differently affected by environmental conditions, like temperature an

Spring flood induced shifts in Fe speciation and fate at increased salinity

Rivers have traditionally been viewed as negligible sources of iron (Fe) to marine waters, as most Fe gets lost during estuarine mixing. However, recent findings demonstrate that Fe from boreal rivers display a higher resistance towards salinity-induced aggregation, presumably due to stabilizing interactions with organic matter. Previous studies have shown that Fe (oxy)hydroxides are selectively r

Photoactivation of Drosophila melanogaster cryptochrome through sequential conformational transitions

Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from Drosophila melanogaster (DmCry) modulates the degradation of Timeless and itself. It is unclear how light absorption by the chromophore and the subsequent redox reactions trigger these events. Here, we use nano- to millisecond time-resolved x-ray solution scattering to reveal the lig

Diffraction in high-energy collisions

Denne afhandling omhandler processer med lave impuls-overførsler i højenergi partikel kollisioner. Disse processer kan ikke beskrives med perturbativ QCD, og baseres derfor ofte på Regge teori, udviklet før QCD. Flere modeller er udviklet indenfor dette område, og enkelte er i denne afhandling blevet udviklet og studeret. Alle modeller er implementeret som numeriske simuleringer (en Monte Carlo evThis thesis concerns itself with low-momentum-transfer processes in high-energy particle collisions. These processes cannot be described in the framework of the fundamental theory of quantum chromodynamics (QCD), but rely on a pre-QCD approach, the Regge theory. Several models containing various degrees of complexity have been proposed within this framework, some of which have been developed and s

Dysmetabolic markers predict outcomes in autosomal dominant polycystic kidney disease

Background: Overweight and obesity were recently associated with a poor prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD). Whether the metabolic consequences of obesity as defined by the metabolic syndrome (MS) are also linked with disease progression remains untested. Methods: Eligible ADPKD patients with different stages of CKD (n = 105) and 105 non-diabetic control

Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Purpose: A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. Methods: This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were revi

Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD

Purpose: The aim of this study is to evaluate plasma biomarkers as predictors for peripheral arterial disease (PAD). Materials and methods: Prospective longitudinal cohort study of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (MDCS) (n = 5550; 1991–94). Cystatin C, copeptin, N-terminal pro-B-type natriuretic peptide (N-BNP), midregional proatrial natriu

Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk

Importance: High gluten intake during childhood may confer risk of celiac disease. Objectives: To investigate if the amount of gluten intake is associated with celiac disease autoimmunity and celiac disease in genetically at-risk children. Design, Setting, and Participants: The participants in The Environmental Determinants of Diabetes in the Young (TEDDY), a prospective observational birth cohort

Oscillometry in Chronic Obstructive Lung Disease : In vitro and in vivo evaluation of the impulse oscillometry and tremoflo devices

Impedance, or oscillometry, measurements of the respiratory system can generate information about the function of the respiratory system not possible with traditional spirometry. There are currently several instruments on the market using different perturbations. We have compared a new respiratory oscillometry instrument, the tremoflo, with Impulse Oscillometry (IOS). Patients with a physician’s d

Accepting surveillance – An increased sense of security after terror strikes?

Over the last two decades, several large terror attacks have led to increased discussion of the use of different surveillance technologies. The use of novel technologies for pre-emptive security and surveillance has been discussed and criticized academically, but few studies have addressed the public. Studies that target the public tend to assume an oversimplified trade-off between privacy and sec

Olagligt, olämpligt, ogiltigt : Förutsättningar för prövning av nulliteter i svensk förvaltningsrätt

I svensk förvaltningsrätt tar diskussioner om utrymmet för överprövning av förvaltningens beslut ofta sin utgångspunkt i begreppsparet laglighet och lämplighet. Därutöver förekommer, mer sällan, argument som relaterar till ogiltighet eller nullitet. Med detta avses förvaltningsbeslut som är grovt och uppenbart felaktiga.Syftet med artikeln är att utreda innebörden av ogiltighet och nullitet i sven

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm : long-term follow-up of a multicentre, randomised trial

Background: The optimal surgical excision margins are uncertain for patients with thick (>2 mm) localised cutaneous melanomas. In our previous report of this multicentre, randomised controlled trial, with a median follow-up of 6·7 years, we showed that a narrow excision margin (2 cm vs 4 cm) did not affect melanoma-specific nor overall survival. Here, we present extended follow-up of this cohort.

Human Leukocyte Antigen-Based Risk Stratification in Heart Transplant Recipients-Implications for Targeted Surveillance

Background Human leukocyte antigen (HLA) matching isn't routinely performed in heart transplantation. Novel allograft perfusion methods may make HLA matching feasible. The purpose of this study is to reexamine whether HLA mismatch may be used in risk stratification to improve outcomes in heart transplantation. Methods and Results We analyzed 34 681 recipients undergoing heart transplantation betwe

Ibrutinib inhibits antibody dependent cellular cytotoxicity induced by rituximab or obinutuzumab in MCL cell lines, not overcome by addition of lenalidomide

Background: The Bruton's Tyrosine Kinase (BTK)-inhibitor ibrutinib is highly active in mantle cell lymphoma (MCL) but may inhibit response to anti-CD20 antibody as previously shown in CLL models. We investigated how antibody-dependent cellular cytotoxicity (ADCC) induced by type I/II anti-CD20 antibodies was affected by treatment with ibrutinib in MCL. Furthermore, we investigated if lenalidomide,

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by neurodegeneration and progressive loss of semantic knowledge. Unlike many other forms of frontotemporal lobar degeneration (FTLD), svPPA has a highly consistent underlying pathology composed of TDP-43 (a regulator of RNA and DNA transcription metabolism). Previous genetic studies of svPPA are limite

First-principles characterization of Mg low-index surfaces : Structure, reconstructions, and surface core-level shifts

In this paper, first-principles calculations provide structural characterization of three low-index Mg surfaces - Mg(0001), Mg(1010), and Mg(1120) - and their respective surface core-level shifts (SCLSs). Inspired by the close similarities between Be and Mg surfaces, we also explore the reconstruction of Mg(1120). Through the calculation of surface energies and the use of the angular-component dec