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Neurotensin (NT) is a gut hormone functioning proinflammatory through nuclear factor kappa B (NF-κB) and interleukin (IL)−8 secretion or anti-inflammatory through epidermal growth factor receptors. NT mRNA is down-regulated in duodenal biopsies of children with untreated coeliac disease. The aim of this study was to investigate if plasma pro-NT levels correlated with the degree of intestinal mucos
Liabilities of newness and smallness as well as other issues (e.g., “imprinting”) that affect nascent firms represent foundational entrepreneurship issues. The articles in this Special Issue examine if and how these critical issues have changed over time, especially given recent innovations (e.g., crowdfunding) and other trends in society. We believe that a special issue devoted to these topics is
beta-Haemolytic streptococci of groups C (GCS) and G (GGS) from human infections typically belong to Streptococcus dysgalactiae and are important human pathogens. Among GGS (183 isolates), several emm-types were identified without significant differences between different sites of isolation. For GCS (79 isolates), the type-distribution was markedly different and more restricted.
We study a two compartment, nonlinear, age structured model for the cell cycle. The phases of the cell cycle G1, S, G2 and M are grouped into two phases, which we call Phase 1 and Phase 2, where Phase 1 consists of the phase G1 and Phase 2 consists of the phases S, G2 and M. It is assumed that Phase 1 has a variable duration while the duration of Phase 2 is fixed. The model consists of a system of
The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the c
Whilst life cycle assessment (LCA) boundaries are expanded to account for negative indirect consequences of bioenergy such as indirect land use change (ILUC), ecosystem services such as water purification sometimes delivered by perennial bioenergy crops are typically neglected in LCA studies. Consequential LCA was applied to evaluate the significance of nutrient interception and retention on the e
Background. Sampling of submucosal lesions in the gastrointestinal tract through a flexible endoscope is a well-recognized clinical problem. One technique often used is endoscopic ultrasound-guided fine-needle aspiration, but it does not provide solid tissue biopsies with preserved architecture for histopathological evaluation. To obtain solid tissue biopsies from submucosal lesions, we have const
To reduce greenhouse gas (GHG) emissions and help mitigate climate change, urban water systems need to be adapted so that electrical energy use is minimised. In this study, energy data from 2011 was used to quantify energy use in China’s urban water supply sector. The objective was to calculate the energy co-benefits of urban water conservation policies and compare energy use between China and oth
This section contains reviews of two Swedish books on international taxation. First, the book Skatteavtal och generalklausuler, Ett komparativt perspektiv (TaxAgreements and General Anti-Avoidance Regulations, A Comparative Perspective) is recommended for those who study and work with international tax law. The book analyses how tax treaties function to limit contracting states’taxing powers relat
The aim of this study is to describe the environmental and climate changes that occurred in the mountains of Aubrac at the transition between the Lateglacial and the Holocene, from a comparative analysis of fossil Coleoptera and pollen, and a series of 23 14C dates. The changes affecting the ecological categories of Coleoptera lead to a division of the sequence into 5 beetle assemblage zones (BAZ)
Purpose To determine the agreement between five different methods of ictal EEG source imaging, and to assess their accuracy in presurgical evaluation of patients with focal epilepsy. It was hypothesized that high agreement between methods was associated with higher localization-accuracy. Methods EEGs were recorded with a 64-electrode array. Thirty-eight seizures from 22 patients were analyzed usin
Genetic characterisation (SSU rRNA genotyping) and Scanning Electron Microscope (SEM) imaging of individual tests were used in tandem to determine the modern species richness of the foraminiferal family Elphidiidae (Elphidium, Haynesina and related genera) across the Northeast Atlantic shelf biomes. Specimens were collected at 25 locations from the High Arctic to Iberia, and a total of 1013 indivi
The warming trend at the end of the last glacial was disrupted by rapid cooling clearly identified in Greenland (Greenland Stadial 1 or GS-1) and Europe (Younger Dryas Stadial or YD). This reversal to glacial-like conditions is one of the best known examples of abrupt change but the exact timing and global spatial extent remain uncertain. Whilst the wider Atlantic region has a network of high-reso
Improving product durability and reparability can save natural resources and money for consumers but may not always be in the best interest of all manufacturers. With the emergence of the circular economy as an important policy objective in the European Union (EU), there is renewed interest in policies to promote durability and address planned obsolescence. Different legislative approaches are cur
Five cases are reported of children with gallstones diagnosed by ultrasound during their first 7 months of life. Of the four with symptomatic gallstones, one subsequently developed vitamin K deficiency syndrome with profuse bleedings. The children, who belonged to a defined population, were all diagnosed within an 18-month span, suggesting the frequency of early gallstone formation to be higher th
A 4-year-old mentally retarded girl had congenital depigmentations of ventrolateral parts of the chest, abdomen, and legs. She also showed dysmorphic features of the head, thorax, and extremities, a pigmented ring in both irises, and a hernia of the left obliquus muscle. Cytogenetic investigations revealed deletion of chromosome 4 for the long arm segment q12-q21. The typical depigmentations, repo
Ten haemophilia centres in northern Europe have pooled data on 202 haemophilic children who were infected with HIV between 1979 and 1986. All cases were under 16 years of age on 1 July 1985. The age at infection ranged from 1-15 years. Thirty-seven cases (18%) had progressed to AIDS by 1 July 1991 and 15 of these have died. Persistent generalised lymphadenopathy has been noted in 102 patients of w
