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Primary Aldosteronism Screening and Diagnosis in Primary Health Care
Popular Abstract in Swedish Högt blodtryck (hypertoni) är en folksjukdom. Omkring 1,8 miljoner personer i Sverige, motsvarande 25 % av den vuxna befolkningen över 20 år, lider av hypertoni. I 90 % av fallen är orsaken okänd och klassificeras då som essentiell/primär hypertoni. Vid sekundär hypertoni finns det en eller flera bakomliggande orsaker till det höga blodtrycket, till exempel: förträngninArterial hypertension is a very common disorder. In most cases the cause is unknown and therefore classified as essential or primary hypertension. Primary aldosteronism (PA), characterized by an inappropriate aldosterone secretion, has traditionally been estimated to account for approximately 1 % of all hypertensive cases. By using the aldosterone to renin ratio (ARR) as a screening tool, the dete
The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer
Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key subsets of mRNAs that cooperate in distinct steps of PCa initiation and progression. Epidemiological ev
Excellent long-term results of the Müller acetabular reinforcement ring in primary total hip arthroplasty.
Background and purpose - The original Müller acetabular reinforcement ring (ARR) shows favorable medium-term results for acetabular reconstruction in total hip arthroplasty, where it is used when the acetabular bone stock is deficient. However, there are no data regarding long-term survival of the device. We therefore investigated long-term survival and analyzed radiological modes of failure. Pati
Tuberculosis burden in an urban population: a cross sectional tuberculosis survey from Guinea Bissau
Background: Little is known about the prevalence of pulmonary tuberculosis (TB) in low income countries. We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding. Methods: Two cohorts were selected based on a previous HIV survey, but only 52.5
Population-based consultation patterns in patients with shoulder pain diagnoses
Background: To assess the annual consultation prevalence and new onset consultation rate for doctor-diagnosed shoulder pain conditions. Methods: We identified all residents in the southernmost county in Sweden who received a shoulder pain diagnosis during 2006 (ICD-10 code M75). In subjects who did not consult due to such disorders during 2004 and 2005, we estimated the new onset consultation rate
Traffic pollution and chronic respiratory disease. Epidemiological studies in children and adults in southern Sweden.
This thesis investigate if long-term exposure to traffic pollution is a risk factor for development of chronic respiratory disease and allergy in adults and children in southern Sweden (Scania). Information about health was obtained from surveys and health care registers. Traffic pollution exposure was estimated by traffic intensity and levels of NOx at residential addresses, which were obtained
Krossa kättarna!
About the crusade against the Cathars in Languedoc.
Emotions in time: Moral emotions appear more intense with temporal distance
Abstract in Undetermined How intense do people expect their future emotional reactions to be? This should depend on the fit between the social perspective (near vs. distant) involved in the emotion and the emotion-eliciting event’s temporal distance. Temporal distance and social distance are interrelated (Trope & Liberman, 2010). We therefore argue that people should anticipate experiencing em
Measurement of charged jet production cross sections and nuclear modification in p-Pb collisions at root s(NN)=5.02 TeV
Charged jet production cross sections in p-Pb collisions at root s(NN) = 5.02 TeV measured with the ALICE detector at the LHC are presented. Using the anti-k(T) algorithm, jets have been reconstructed in the central rapidity region from charged particles with resolution parameters R = 0.2 and R = 0.4. The reconstructed jets have been corrected for detector effects and the underlying event backgrou
Comparison of hygrothermal measurements and calculations in a single-family wooden house in the Swedish town of Växjö
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus
Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS beta-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes. Interestingly, neutrophils and monocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but s
Challenges of measuring body temperatures of free-ranging birds and mammals
The thermal physiology of most birds and mammals is characterised by considerable spatial and temporal variation in body temperature. Body temperature is, therefore, a key parameter in physiological, behavioural and ecological research. Temperature measurements on freely moving or free-ranging animals in the wild are challenging but can be undertaken using a range of techniques. Internal temperatu
Controllability as a Contextual Variable
No title
Four-Year Durability of Initial Combination Therapy with Sitagliptin and Metformin in Patients with Type 2 Diabetes in Clinical Practice; COSMIC Study.
We investigated the efficacy of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes for 4 years in clinical practice.
Temperature sensitivity of bacterial growth in a hot desert soil with large temperature fluctuations
Hot desert ecosystems are characterized by high soil temperatures with large fluctuations annually and diurnally. Thus, one could hypothesize that not only the microbial community would be adapted to high temperatures, but also have a large temperature range conducive for growth. We determined the temperature sensitivity of the soil bacterial community from the Chihuahuan Desert, Big Bend National
A transient peak of infections during onset of rheumatoid arthritis: a 10-year prospective cohort study.
The role of infection in rheumatoid arthritis (RA) has not been determined. We aimed to document the infectious burden and some aspects of antibacterial immunity in a large and prospective cohort study of RA patients in the early and late stages of the disease and in their relatives predisposed to RA.
Prediktion av postoperativ smärta ger nya möjligheter. Skräddarsydd smärtlindring kan hindra att långvarig, svår smärta utvecklas.
Secondary electron imaging of nanostructures using Extreme Ultra-Violet attosecond pulse trains and Infra-Red femtosecond pulses
Surface electron dynamics unfold at time and length scales down to attoseconds and nanometres, making direct imaging with extreme spatiotemporal resolution highly desirable. However, this has turned out to be a major challenge even with the advent of reliable attosecond light sources. In this paper, photoelectrons from Ag nanowires and nanoparticles excited by extreme ultraviolet (XUV) attosecond