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The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.

Studies of determinants of development of inhibitory antibodies to factor VIII in people with hemophilia A indicate a complex process involving multiple factors. The Hemophilia Inhibitor Genetics Study Combined Cohort was formed to extend understanding of the genetic background of risk. The study group contains 833 subjects from three independent cohorts: brother pairs and singletons with and with

Haemophilus influenzae: recent advances in the understanding of molecular pathogenesis and polymicrobial infections.

Non-typeable Haemophilus influenzae (NTHi) is a human-specific mucosal pathogen and one of the most common causes of bacterial infections in children and patients with chronic obstructive pulmonary disease. It is also frequently found in polymicrobial superinfections. Great strides have recently been made in the understanding of the molecular mechanisms underlying NTHi pathogenesis.

The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

Immune escape mechanisms promote tumor progression and are hurdles of cancer immunotherapy. Removing immunosuppressive cells before treatment can enhance efficacy. Tyrosine kinase inhibitors (TKI) may be of interest to combine with immunotherapy, as it has been shown that the inhibitor sunitinib reduces myeloid suppressor cells in patients with renal cell carcinoma and dasatinib promotes expansion

Josef Hammar (1868-1927) - a Swedish physician in the Anglo-Boer War (1899-1902).

It is well-known that the Anglo-Boer War attracted support and sympathy for the Boer cause from all over Europe. One topic that has not received much scholarly attention, however, is the contribution of Scandinavian medical doctors and nurses in the conflict. One of them was the Swedish surgeon Josef Hammar. This article argues that his participation was for both idealistic and pragmatic reasons.

Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression.

We report that many histone modifications are unevenly distributed over the HPV16 genome in cervical cancer cells as well as in HPV16-immortalized keratinocytes. For example, H3K36me3 and H3K9Ac that are common in highly expressed cellular genes and over exons, were more common in the early than in the late region of the HPV16 genome. In contrast, H3K9me3, H4K20me3, H2BK5me1 and H4K16Ac were more

Body mass index (BMI) and dental caries in 5-year-old children from southern Sweden.

OBJECTIVES: The aim of the present survey was to study the association between dental caries and body mass index (BMI) in Swedish preschool children (born in 1999). METHODS: A population-based and cross-sectional study design was used comprising all 920 5-year-old children in a defined area in and around the city of Lund. Anthropometric measures for the calculation of BMI were retrieved for each

Barrier properties of heat treated starch Pickering emulsions.

There is a recognized technological need for delivery systems encapsulating lipophilic substances in food and pharmaceutical products. Pickering emulsions can provide well-defined and highly stable systems, but may not provide good enough barrier properties. Starch granules, recently being used for Pickering stabilization, have the advantage of the ability to swell during gelatinization. Hence, th

Searching for doubly charged vector bileptons in the golden channel at the LHC

In this paper we investigate the LHC potential for discovering doubly charged vector bileptons considering the measurable process p, p -> e(-/+) e -/+ mu(+/-) mu(+/-) X. We perform the study using four different bilepton masses and three different exotics quark masses. Minimal LHC integrated luminosities needed for discovering and for setting limits on bilepton masses are obtained for both 7 and 1

Lack of supportive evidence for the use of immunohistochemical staining to identify occult regional lymph node metastases in primary lung cancer.

Immunohistochemical (IHC) staining for the identification of nodal occult metastases (OM), not detected by routine histological examination, has been proposed for improved staging, prognostication and decision of adjuvant treatment in surgically treated primary lung cancer. In a prospective study, we analysed 178 cases of primary lung cancer stage I-III (N0-N1) for OM by immunostaining lymph node

The parasites: Synchrotron radiation at SLAC, 1972-1992

The synchrotron radiation activities at SLAC National Accelerator Laboratory (formerly Stanford Linear Accelerator Center) started out in 1972 as a small-scale Stanford University project. The project gradually grew to become one of the first national centers for synchrotron radiation in the United States and, eventually, an independent laboratory in charge of its own accelerator machine and organ

Reducing disaster risks 1980-2010: Some reflections and speculations

Through personal reflections on themes covering past experiences, the author considers selected experiences of disaster risk management (DRM) that span 30 years of DRM, and makes some speculations concerning the future, and ponders whether within the selected themes the future looks positive or negative. The observations begin with some memories of the Ocho Rios Conference: a multi disciplinary ex

Is the fact of parenting couples cohabitation affecting the serum levels of persistent organohalogen pollutants?

Organohalogen compounds constitute one of the important groups of persistent organic pollutants (POPs). Among them, due to their long-term health effects, one should pay attention on organochlorine pesticides, polychlorinated biphenyls (PCBs) and perfluoroalkylated substances (PFASs). This paper is an attempt to answer the question about relation between the fact of cohabitation by couples expecti

Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model

True tendon regeneration in human patients remains a vision of musculoskeletal therapies. In comparison to other mesenchymal lineages the biology of tenogenic differentiation is barely understood. Specifically, easy and efficient protocols are lacking that might enable tendon cell and tissue differentiation based on adult (stem) cell sources. In the murine mesenchymal progenitor cell line C3H10T1/

From 1D Rods to 3D Networks: A Biohybrid Topological Diversity Investigated by Asymmetrical Flow Field-Flow Fractionation

Biohybrid structures formed by noncovalent interaction between avidin as a bridging unit and biotinylated glycodendrimers based on poly(propyleneimine) (GD-B) have potential for biomedical application. Therefore, an exact knowledge about molar mass, dispersity, size, shape, and molecular structure is required. Asymmetrical flow field-flow fractionation (AF4) was applied to separate pure and assemb

Influence of anisotropic grain boundary properties on the evolution of grain boundary character distribution during grain growth - a 2D level set study

The present study elaborates on a 2D level set model of polycrystal microstructures that was recently established by adding the influence of anisotropic grain boundary energy and mobility on microstructure evolution. The new model is used to trace the evolution of grain boundary character distribution during grain growth. The employed level set formulation conveniently allows the grain boundary ch

The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma

Background GSK2190915, a potent 5-lipoxygenase-activating protein inhibitor, prevents the synthesis of leukotrienes and 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Objective To assess the effect of GSK2190915 on the allergen-induced asthmatic responses. Methods Nineteen eligible male subjects with mild asthma were enrolled in and completed this four-centre, double-blind, two-way crossover s

Soft Tissue Knee Injury With Concomitant Osteochondral Fracture Is Associated With Higher Degree of Acute Joint Inflammation.

BACKGROUND:Osteochondral fractures are often seen on magnetic resonance imaging (MRI) of acutely injured knees, but their existence has gained little interest because of a lack of knowledge of their relation to treatment options and outcome. It is not clear whether acute phase synovial fluid (SF) concentrations of cartilage and bone markers and proinflammatory cytokines are different between traum