Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DAMPs), are indispensable for manifestation of local inflammation. S100A8/S100A9 complexes are the most abundant DAMPs in many autoimmune diseases. However, regula

Objective: In patients presenting with acute type-A aortic dissection (aTAAD), lactic acid measurement is a frequently used analysis for diagnosis of acute ischemia, which may have a dismal prognosis. The aim of the current study was to determine the performance of perioperative arterial lactic acid measurements in predicting outcome in aTAAD patients. Design: Retrospective, observational study. S

Lately, different wearable form factors have reached the consumer domain. Wearables enable at-a-glance access to information and can continually sense the surrounding environment. Internet of Things (IoT) researchers have focused on the main enabling factors: The integration of several technologies and communication solutions. Less effort has been devoted to exploring how not-so-tech-savvy end use

Background: Environmental lead exposure has been associated with decreased kidney function, but evidence from large prospective cohort studies examining low exposure levels is scarce. We assessed the association of low levels of lead exposure with kidney function and kidney disease. Study Design: Prospective population-based cohort. Setting & Participants: 4,341 individuals aged 46 to 67 years

The behavioural lateralisation of a species is thought to be influenced by social organisation. However, recent studies of insect species with different social structures suggest that traits showing both population-level and individual-level lateralisation can be found in single species. This has broad implications for our understanding of how lateralisation and handedness evolves.

Urban living labs (ULLs) offer opportunities to foster sustainability in cities. They are sites to design, test and learn from innovation in real time. A key element in the operation and success of ULLs is user involvement. Users are often viewed as co-creators who shape ULL outcomes by contributing with their knowledge and experi ence. The transformative potential of ULLs for sustainability is of

Fluoroscopic examinations of the upper gastro-intestinal tract and, especially, barium meal examinations, are commonly performed in a majority of hospitals. These examinations are associated both with substantial individual patient doses and contribution to the collective dose from medical exposure. Effective dose estimation for this type of examinations is complicated due to: 1) the necessity to

We used quantitative semantics to find clusters of words in LinkedIn users' self-descriptions to an employer or a friend. Some of these clusters discriminated between worker and friend conditions (e.g., flexible vs. caring) and between LinkedIn users with high and low education (e.g., analytical vs. messy).

The focus of this thesis is on proposing and analyzing a powerful class of codes on graphs---with trellis constraints---that can simultaneously approach capacity and achieve very low error floor. In particular, we propose the concept of spatial coupling for turbo-like code (SC-TC) ensembles and investigate the impact of coupling on the performance of these codes. The main elements of this study ca

Recension av Jurij Rybin, Boris Safonov. Luftwaffes baneman på östfronten

This article chronicles and analyzes the history of the third sector of R&D in Sweden, which corresponds to an organizational field of research institutes outside academia and private firms. Using secondary sources and governmental documentation, the chronicle begins with the forming of a number of industry-specific and industry-owned institutes in the 1940s and ends with today’s reformed and

The impact of different passive protective measures against external vertical fire spread was investigated using the numerical tool Fire Dynamics Simulator (FDS). The numerical study was divided into a validation study and a comparative analysis. The validation study was performed to evaluate FDS as a calculation tool for modelling external vertical fire spread and was conducted using experimental

The present article argues that the fact that personal data holds great value, in combination with a lack of transparency in its commercial use, leads to a need for consumer policy that strengthens consumer protection. The widespread practice of user agreements and consent-based regulation of personal data collection is not satisfactory for balancing these information-asymmetric markets. The lack The present article argues that the fact that personal data holds great value, in combination with a lack of transparency in its commercial use, leads to a need for consumer policy that strengthens consumer protection. The widespread practice of user agreements and consent-based regulation of personal data collection is not satisfactory for balancing these information-asymmetric markets. The lack

The Gram-negative bacterial outer membrane contains lipopolysaccharide, which potently stimulates the mammalian innate immune response. This involves a relay of specialized complexes culminating in transfer of lipopolysaccharide from CD14 to Toll-like receptor 4 (TLR4) and its co-receptor MD-2 on the cell surface, leading to activation of downstream inflammatory responses. In this study we develop

The maximum work rate of animals has recently been suggested to be determined by the rate at which excess metabolic heat generated during work can be dissipated (heat dissipation limitation (HDL) theory). As a first step towards testing this theory in wild animals, we experimentally manipulated brood size in breeding marsh tits (Poecile palustris) to change their work rate. Parents feeding nestlinThe maximum work rate of animals has recently been suggested to be determined by the rate at which excess metabolic heat generated during work can be dissipated (heat dissipation limitation (HDL) theory). As a first step towards testing this theory in wild animals, we experimentally manipulated brood size in breeding marsh tits (Poecile palustris) to change their work rate. Parents feeding nestlin