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Histone deacetylase inhibitors (HDIs) and HAMLET (human alpha-lactalbumin made lethal to tumor cells) interact with histones, modify the structure of chromatin, and trigger tumor cell death. This study investigated how the combination of HDIs and HAMLET influences cell viability, histone acetylation, and DNA integrity. The pretreatment of tumor cells with HDIs was shown to enhance the lethal effec
In many control problems, e.g. in biology, time delays of the order of seconds or more play an important role. The present device is intended for simulations of such problems. Its accuracy (0·1 per cent) is of the same magnitude as that for most analogue computer components. It has been used in preliminary experiments (Fig. 5) to study biological rhythms. However, many differential equations with
BACKGROUND: The incidence of type 1 diabetes in Europe is increasing at a rate of about 3% per year and there is also an increasing incidence throughout the world. Type 1 diabetes is a complex disease caused by multiple genetic and environmental factors. Persistent organochlorine pollutants (POPs) have been suggested as a triggering factor for developing childhood type 1 diabetes. The aim of this
A signal–code construction is proposed that ensures a better relationship between decoding reliability and complexity than the classical scheme. The coder is partitioned into several “elementary” binary convolutional coders and the decoder is partitioned into several Viterbi decoders. The transmission of PSK-modulated signals is considered in more detail.
Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohor
Male cancer survivors (MCS) are at risk of suffering from impaired fertility. Male fertility is dependant on sperm DNA quality. The Sperm Chromatin Structure Assay (SCSA) reflects the proportion of sperm with poor DNA, the DNA fragmentation index, DFI. A high DFI indicates reduced in vivo fertility and the need of ICSI (Intracytoplasmic sperm injection) to achieve pregnancy. A concern with ICSI, i
The aim was to investigate the construct validity and internal consistency of the Swedish version of the Consumer Emergency Care Satisfaction Scale. The sample comprised 157 persons from an emergency department and an observation ward. The results showed satisfactory reliability, and an explorative factor analysis revealed 3 factors: Caring, Teaching, and Clinical Competence. The Swedish version o
We have measured the absolute average photon flux, the spectral characteristics, and the time structure of x rays emitted from Ar clusters which were irradiated by a 100 fs laser with an intensity of 10(17) W/cm(2). The measured photon flux was 10(7) photons per shot in the K-alpha (at 3 keV) line in a 4 pi sr solid angle. The temporal structure was measured using a streak camera with a 10 ps time
The Transplantation Society, in collaboration with the Canadian Society of Transplantation, organized a forum on education on ODT for schools. The forum included participants from around the world, school boards, and representatives from different religions. Participants presented on their countries' experience in the area of education on ODT. Working groups discussed about technologies for educat
PURPOSE: Postoperative hypocalcaemia has been reported to be more common after total thyroidectomy (TT) for Graves' disease than after TT for benign atoxic multinodular goitre (MNG). The reasons for this potential association are not clear. In the present study, the frequency and risk factors of hypocalcaemia after TT for Graves' vs MNG were compared. METHODS: Between January 1999 and October 2009
OBJECTIVE: To describe the sonographic characteristic of squamous cell cancer (SCC) and adenocarcinoma (AC) of the cervix using transvaginal ultrasound. METHODS: Women with early stage cervical cancer undergoing transvaginal ultrasound examination prior to surgery were prospectively included. The sonographic characteristics were assessed with regard to tumor morphology, vascularization, size, exte
Popular Abstract in Swedish Denna avhandling handlar om byggnadsarkeologiska sätt att närma sig historiska byggnader. Syftet är att visa hur byggnadsarkeologin kan förnyas och utvecklas. Motivet är min uppfattning att byggnadsarkeologin inte till fullo utnyttjar de stående byggnadernas potential som historiska källor, vilket framför allt beror på ett traditionsbundet synsätt, som innebär att man nThis dissertation is about the way buildings archaeology approaches historical buildings. The aim is to show how buildings archaeology can be renewed and developed. The motivation is my belief that buildings archaeology does not fully utilize the potential of standing buildings as historical sources, which is mainly due to the traditional outlook on buildings as two-dimensional objects. When three
