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Particle packings are widely used in process applications, yet often have poor flow distribution due to random channel geometries. Regular channels can now be realised using 3D-printing, where tuneable channel morphology also offers the possibility of promoting vortices and fluctuating motion to enhance heat and mass transfer. Detailed visualisation experiments are required to understand hydrodyna
The unprecedented x-ray flux density provided by modern x-ray sources offers new spatiotemporal possibilities for x-ray imaging of fast dynamic processes. Approaches to exploit such possibilities often result in either (i) a limited number of projections or spatial information due to limited scanning speed, as in time-resolved tomography, or (ii) a limited number of time points, as in stroboscopic
Recent research has highlighted the importance of reducing economic shrinking—periods of negative per capita growth—for long-term development. Building on this literature, this chapter proposes a new framework explicitly connecting the dynamics of poverty eradication to the dynamics of resilience to economic shrinking. It argues that a key driver of this resilience is the alignment of incentives b
Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer's disease. However, poor quality MR images can lead to unreliable segmentation of MTL subregions. Considering that different MRI contrast mechanisms and field strengths (jointly referred to as “modalities” here) offer distinct advantages in imaging differen
Background: Acute kidney injury (AKI) is a common complication of coronary artery bypass surgery (CABG) and is associated with worse outcomes. It remains unclear whether AKIs impact on prognosis can be attributed to other concurrent major complications. Methods: This retrospective cohort study included consecutive patients undergoing isolated CABG at a single nationwide center from 2001 to 2020. P
Fe-based metal amorphous nanocomposites, consisting of dispersed nanocrystallites within an amorphous metallic glass matrix, are used as low-loss soft-magnetic components in energy conversion devices. The nanocrystallites are formed by partial devitrification of the amorphous matrix and the properties of the composite are a result of the devitrification process. Understanding the rate-dependent cr
It is a well-established fact that the use of gestures is a ubiquitous feature of communication with language. This is true for both spoken and signed languages. However, while in spoken languages, gestures are produced in a different modality than speech (visual versus vocal/auditory, respectively), gestural elements in sign languages are produced in the same modality as sign (both are visual). T
This study investigates the interaction dynamics of directly injected (DI) hydrogen and methane jets with wall and neighboring jets in a non-reactive environment, focusing on the influence of wave-shaped piston geometry. Experiments were conducted in a high-pressure optical chamber using a custom 2-hole DI injector, with Schlieren imaging employed to capture the temporal evolution of jet structure
Laminin, a critical component of the basement membrane, plays an indispensable role in numerous biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a key player in the progression of cancer. This review delves into the current understanding of LAMC2′s role, highlighting its significant contribution to cancer development through promoting cell proliferation, invasion, and va
Multiple myeloma (MM) is a hematological disease of the plasma cell that remains clinically challenging despite the development of novel therapies. Epigenetic alterations have been demonstrated to contribute to MM pathogenesis, yet comprehensive studies into the links between different epigenetic regulatory systems in myeloma progression and drug resistance, though clinically relevant, are largely
Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset diversification remains poorly understood. Here, we employed a sequential anchored screen of 70 transcription factors using direct cellular reprogramming to identify regulators that specify type 2 conventional DCs (cDC2s) and plasm
