Background: A large number of gene expression profiling (GEP) studies on prognosis of colorectal cancer (CRC) has been performed, but no reliable gene signature for prediction of CRC prognosis has been found. Bioinformatic enrichment tools are a powerful approach to identify biological processes in high-throughput data analysis. Principal Findings: We have for the first time collected the results

BACKGROUND: Overexpression of the PGM2 gene encoding phosphoglucomutase (Pgm2p) has been shown to improve galactose utilization both under aerobic and under anaerobic conditions. Similarly, xylose utilization has been improved by overexpression of genes encoding xylulokinase (XK), enzymes from the non-oxidative pentose phosphate pathway (non-ox PPP) and deletion of the endogenous aldose reductase

En inventering och presentation av fr.a. svensk forskning om diakoni och kyrkors sociala verksamheter. Först redovisas historisk forskning om fattigvård och diakoni. Därefter samhälls- och flervetenskaplig forskning, samt forskning om diakonatet och systematisk-teologisk forsknning

Popular Abstract in Swedish Primär hyperparathyroidism (PHPT) är en sjukdom som beror på abnormt ökad produktion av parathormon (PTH) i en eller flera av de vanligen fyra bisköldkörtlarna. PTH har som uppgift är att reglera nivån av kalcium i blodet (i dagligt tal ofta kallad ”blodkalken”) inom snäva gränser. Den förhöjda halten av PTH och den åtföljande stegringen av kalciumnivån i blodet vid PHPPrimary hyperparathyroidism (PHPT) is associated with cardiovascular morbidity and premature death, but the underlying mechanisms are incompletely understood. The aim of this thesis was to investigate cardiovascular parameters and adrenergic function in mild PHPT compared to healthy controls subjects before and after curative parathyroidectomy (PTX). Forty-nine patients with mild PHPT (serum calci

Geomagnetically induced currents (GICs) flow mainly through power lines, earthed transformers and earth itself. The near DC currents may cause half-cycle saturation of transformers, possibly causing relay misoperation, increased reactive power demand and damage to transformers. This paper describes a patented idea to make a transformer immune to GIC using compensation windings in each phase. A com

A small rectangular strip of fcc Cu, containing a through crack on the nanoscale and subjected to loading under displacement control, is simulated using molecular dynamics (MD). The geometry is highly constrained and chosen to mimic that of a thin strip between two stiff layers. The Lennard-Jones pair potential is used for the inter-atomic forces. The centrally placed crack shaped void is created

This article deals with the impact of retail rhythms on urban life and the urban landscape, with a special focus on tendencies toward synchronisation. The article is divided into three sections. First, the history of synchronisations in public space is traced, and it is argued that the retail business has become an increasingly important actor in the production of urban temporal landscapes. Second

PHENIX has measured the electron-positron pair mass spectrum from 0 to 8 GeV/c(2) in p + p collisions at root s = 200 GeV. The contributions from light meson decays to e(+)e(-) pairs have been determined based on measurements of hadron production cross sections by PHENIX. Within the systematic uncertainty of similar to 20% they account for all e(+)e(-) pairs in the mass region below similar to 1 G

Background: Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques

Complementary measures for the assessment of patient thermoregulatory state, such as subjective judgement scales, might be of considerable importance in field rescue scenarios where objective measures such as body core temperature, skin temperature, and oxygen consumption are difficult to obtain. The objective of this study was to evaluate, in healthy subjects, the reliability of the Cold Discomfo

The notion of experience economy asserts that staging the most mundane consumption practise as individualized entertainment adds value to the producer and consumer alike (Pine and Gilmore, 1999). This article questions this assumption of mere added value. Probing into an interplay between a marketing fantasy and a customer movement passionately engaging with its promise, it draws attention to a st

A systematic study of compounds formed by solvolysis of Cu in a solution of iodine in acetol in the presence of homotetraalkylammonium iodide has resulted in five new compounds: catena tetrakis (tetramethylammonium) bis(mu(3)-iodo)-mu(2)-iodo-tri-copper(I), hexakis(tetrabutylammonium) tetrakis(mu(3)-iodo)-tris(mu(2)-iodo)-di-iodo-hexa-copper(I) pentakis(mu(3)-iodo)-tetrakis(mu(2)-iodo)-di-iodo-hep

Recension av Tarje Emberland & Matthew Kott, Himmers Norge – Nordmenn i det storgermanske prosjekt.

Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro