Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor, och under år 2011 fick över 8000 svenska kvinnor denna diagnos. Termen bröstcancer är egentligen ett samlingsnamn för alla de olika typer av cancer som kan uppstå i bröstet. En del typer av bröstcancer har en bra prognos medan andra trots aggressiv behandling alltjämt har en dålig prognos. Cancer är en sjukdom dBreast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote

Tracking migratory movement of small animals with variable migration patterns is difficult with standard mark-recapture methods or genetic analysis. We used stable hydrogen isotope (delta D) measurements of wings from European red admirals Vanessa atalanta to study several aspects of this species' migration. In the central part of southern Europe we found large differences in delta D values betwee

The problems of allocation of scarce resources and priority setting in health care have so far not been much studied in the context of stem cell-based therapeutic applications. If and when competitive cost-effective stem cell-based therapies are available, the problem of priority setting - to whom should stem cell-based therapies be offered and on what grounds - is discussed in this article using

Popular Abstract in Swedish Förlossning efter kejsarsnitt Kejsarsnitt utgör för närvarande cirka 17% av alla förlossningar i Sverige. En konsekvens av detta är att allt fler kvinnor kommer till specialistmödravården för rådgivning om vilket förlossningssätt som är säkrast vid förlossningen efter ett kejsarsnitt. Två möjligheter finns: planerad vaginal förlossning eller planerat kejsarsnitt. När maBirth after caesarean section (CS) is an issue of growing importance. As a consequence of increasing CS rates, more women having experienced a prior CS will need counselling about preferred second delivery mode. There are two choices: elective repeat caesarean section (ERCS) or trial of labour (TOL). It is well known, that a TOL ending in an emergency CS carries the largest risks for mother and ch

The purpose of this project was to investigate the possibilities to manufacture wet-glued laminated beams for load bearing applications from Norway spruce side board lamellae and by that achieve products that are difficult to obtain from the centre yield of a log and also contribute to increased profitability in the sawmill industry. Properties such as shape stability, strength and stiffness of we

The overall aim of this thesis was to provide a representative estimate of the potential impacts of climate change and increased atmospheric CO2 concentrations on Swedish forest ecosystems and the key ecosystem services they provide. In order to achieve this task, fi rst LPJ-GUESS, a process-based regional ecosystem modelling framework, was applied to explore how possible shifts in climatic zones

Therapy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in cancer patients. We investigated the long-term consequences of genetically impaired angiogenesis by engineering multiple tumor models deprived of endoglin, a co-receptor for TGF-beta in endothelial cells actively engaged in angiogenesis. Tumors from endoglin-deficient mice adapted to the weakened

A critical source publication of an unknown letter from the late eighteenth century, of great importance for the later interpretation of the German Moravian spiritual tradition in Sweden.

Background: Resource allocation in public health care principally involves politicians, administrators, and physicians. They all have their different roles, agendas and ambitions when it comes to how public health care resources should be spent. Previous studies on attitudes among health-care stakeholders have mainly focused on views and preferences among clinical decision-makers, while less atten

Recension av Kazimiera Ingdahl: Icke helt och hållet skall jag dö. Den ”judiska frågan” i Polen.

We report the observation of anomalous bands in graphite valence band structure in angle-resolved photoemission spectroscopy (ARPES) experiments. The photon energy dependence of these bands shows a constant kinetic energy nature. Our results are supported by the very low energy electron diffraction data reported on graphite surfaces which essentially map the unoccupied states representing the phot

Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute myeloid leukemia have a poor outcome. We hypothesized that increasing doses of lenalidomide may benefit this group of patients by inhibiting the tumor clone, as assessed by fluorescence in situ hybridization for del(5q31). Design and Methods Twenty-eight patients at diagnosis or with relapsed disea

Differential absorption lidar (DIAL) techniques have been utilized to measure elemental gaseous mercury fluxes from mercury cell chlor-alkali (MCCA) plants as a part of the European Union funded European mercury emissions from chlor-alkali plants (EMECAP) project. Three plants have been selected as study objects and a total of six measurement campaigns have been performed, one intercalibration cam

Between May and December 1998, tick-associated febrile illness was prospectively studied in Southeast Sweden in order to assess the occurrence of human granulocytic ehrlichiosis (HGE). Inclusion criteria were fever (greater than or equal to 38.0degreesC), with or without headache, myalgia or arthralgia in patients with an observed tick bite or tick exposure within 1 month prior to onset of symptom

Three recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilanceThree recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilance