Microvascular pathology in the brain is one of the suggested mechanisms underlying the increased incidence and progression of neurodegenerative diseases in people with type 2 diabetes (T2D). Although accumulating data suggest a neuroprotective effect of antidiabetics, the underlying mechanisms are unclear. Here, we investigated whether two clinically used antidiabetics, the dipeptidyl pep-tidase-4

Large-scale bars can fuel galaxy centers with molecular gas, often leading to the development of dense ringlike structures where intense star formation occurs, forming a very different environment compared to galactic disks. We pair ∼0.″3 (30 pc) resolution new JWST/MIRI imaging with archival ALMA CO(2-1) mapping of the central ∼5 kpc of the nearby barred spiral galaxy NGC 1365 to investigate the

The relationship between human rights and Islam is important in countries of the Arab world where religion plays a significant role in public debates and daily life. The topic is particularly relevant at a time of sharpening conflicts and polarization, when forms of government in the region, the current world order, and the legitimacy of international organizations are increasingly contested. Much

Optimal time spans in homograft procurement are still debatable among tissue banks and needs to be further investigated. Cell viability decreases at longer preparation intervals, but the effect on collagen and elastic fibers has not been investigated to the same extent. These fibers are of importance to the homograft elasticity and strength. The objective of this study was to analyze the mechanica

Connected autonomous vehicles can significantly improve the safety and mobility of urban transportation systems. However, these systems are vulnerable to model uncertainties, wireless communication impairments, and external disturbances. In this article, we propose a new autonomous intersection management (AIM) system, called hierarchical model predictive control (HMPC). In HMPC, the intersection

Family Report: Two rare autosomal recessive neurological disorders, leukoencephalopathy with ataxia and spastic paraplegia 56 (SPG56), were found in members of the same family. Two siblings presented with spastic paraplegia, cognitive impairment, bladder and bowel dysfunction and gait ataxia; their consanguineous parents were unaffected. Ophthalmological examination revealed chorioretinopathy. Bra

We explore the potential of ultimate unification of the Standard Model matter and gauge sectors into a single (Formula presented.) superfield in ten dimensions via an intermediate Pati–Salam gauge theory. Through a consistent realisation of a (Formula presented.) orbifolding procedure and renormalisation group evolution of gauge couplings, we establish several novel benchmark scenarios for New Phy

Syftet med studien är att beskriva hur metoo har påverkat synen på sexuella trakasserier inom arbetslivet. Dessutom är syftet att beskriva och analysera hur ett ledarskap kan se ut för att aktivt motverka sexuella trakasserier i organisationer. Vi har valt en kvalitativ ansats som grundar sig på semistrukturerade intervjuer med sju HR-praktiker. Intervjuerna genomfördes digitalt och analyserades m

PURPOSE: The Swedish InfCareHIV cohort was established in 2003 to ensure equal and effective care of people living with HIV (PLHIV) and enable long-term follow-up. InfCareHIV functions equally as a decision support system as a quality registry, ensuring up-to-date data reported in real time.PARTICIPANTS: InfCareHIV includes data on >99% of all people with diagnosed HIV in Sweden and up to now 13 0

This chapter provides a critical discussion of the mediatization of policy in general, and of EU foreign and security policy in particular. A common argument in public debate and research is that the media logic is increasingly affecting how policy is formulated. Brommesson and Ekengren are critical of this (as they see it) oversimplified perspective, and they analyse EU foreign and security polic

»Otrygga jobb«, säger vänstern. »Ovärdiga jobb«, svarar den konservativa högern. Men gigekonomin är här för att stanna. Hur kan politiken utformas för att värna gigjobbarna och till fullo utnyttja den nya teknikens potential?Andreas Bergh är nationalekonom och välfärdsforskare vid Institutet för Näringslivsforskning (IFN) och Lunds universitet. Joakim Wernberg är forskningsledare för Digitaliserin

Background The genetic background of general obesity and fat distribution is different, pointing to separate underlying physiology. Here, we searched for metabolites and lipoprotein particles associated with fat distribution, measured as waist/hip ratio adjusted for fat mass (WHRadjfatmass), and general adiposity measured as percentage fat mass. Method The sex-stratified association of 791 metabol

Bumblebees are a key taxon contributing to the provision of crop pollination and ecosystem functioning. However, land use and climate change are two of the main factors causing bee decline across the world. In this study, we investigated how the flight period of bumblebee spring queens has shifted over the last century in Sweden, and to what extent such shifts depended on climate change, landscape

En essä om hur regleringen av stora techföretag och digitala marknader kan komma att påverka små och medelstora företag och framtida techföretag.

Redovisning av en omfattande enkätundersökning om 5000 chefers syn på nuläge och utveckling i arbetsliv, organisation och ledarskap i pandemins kölvatten. Rapport utgiven av Ledarna.

This study considers the numerical modeling of sub-breakdown microwave-enhanced combustion in one-dimensional laminar methane-air flames over a range of stoichiometries at standard temperature and pressure. The effect of uniform microwave fields on the laminar flame speed, post-flame temperature and composition is of primary interest here. A model for the non-thermal plasma generated by the microw

The international UN Climate Change conferences known as “Conferences of the Parties (COPs)” have an enormous convening power and are attended annually by tens of thousands of actors working on climate change topics from a wide range of perspectives. In the COP spaces outside of the formal negotiations, the communication culture is dominated by “side events,” a format that relies heavily on conven

Background: Prognostic assessment of ventricular tachycardia (VT) or ventricular fibrillation (VF) in ST-segment elevation myocardial infarction (STEMI) is based mainly on distinguishing between early (