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Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage.

Molecular mechanisms behind increased cerebral vasospasm and local inflammation in late cerebral ischemia after subarachnoid hemorrhage (SAH) are poorly elucidated. Using system biology tools and experimental SAH models, we have identified signal transducer and activator of transcription 3 (STAT3) transcription factor as a possible major regulatory molecule. On the basis of the presence of transcr

Surgical management of peritonitis secondary to acute superior mesenteric artery occlusion.

Diagnosis of acute arterial mesenteric ischemia in the early stages is now possible using modern computed tomography with intravenous contrast enhancement and imaging in the arterial and/or portal phase. Most patients have acute superior mesenteric artery (SMA) occlusion, and a large proportion of these patients will develop peritonitis prior to mesenteric revascularization, and explorative laparo

Direct observation of Young's double-slit interferences in vibrationally resolved photoionization of diatomic molecules.

Vibrationally resolved valence-shell photoionization spectra of H(2), N(2) and CO have been measured in the photon energy range 20-300 eV using third-generation synchrotron radiation. Young's double-slit interferences lead to oscillations in the corresponding vibrational ratios, showing that the molecules behave as two-center electron-wave emitters and that the associated interferences leave their

Reactivity and Mass Transfer of Low-Dimensional Catalysts

Understanding the mechanisms governing chemical and morphological changes induced by an ambient-pressure gas and how such changes influence the activity of heterogeneous catalysts is central to the formation of a predictive capability for structure-reactivity relationships. With techniques such as ambient-pressure photoelectron spectroscopy, scanning tunneling microscopy, and surface X-ray diffrac

Guidance on handheld inhalers in asthma and COPD guidelines.

Inhaled therapy is the cornerstone of pharmacotherapy in patients with asthma and chronic obstructive pulmonary disease (COPD). Appropriate inhalation device selection is as important as drug choice but device-specific guidance appears to be lacking.

Formation of the Scandinavian Obesity Surgery Registry, SOReg.

Obesity surgery is expanding, the quality of care is ever more important, and learning curve assessment should be established. A large registry cohort can show long-term effects on obesity and its comorbidities, complications, and long-term side effects of surgery, as well as changes in health-related quality of life (QoL). Sweden is ideally suited to the task of data collection and audit, with un

Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?

Elevated prediagnostic testosterone and insulin-like growth factor I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage and they may have clinical utility as HCC risk markers. A case-control study was nested within the European Prospective Investigation into Cancer and N

Chemical solution deposition of thin films for protonic ceramic fuel cells

Chemical solution deposition (CSD) offers the opportunity to fabricate very thin electrolyte films at lower temperatures than traditional powder-based methods. CSD methods have not been used much in production of protonic ceramic fuel cells (PCFC) until now. In this contribution we describe thin film deposition of the two proton-conducting materials BaZr0.9Y0.1O3 (-) (delta) (BZY) and La28 - xW4 +

Measurement of the transverse momentum distribution of W bosons in pp collisions at root s=7 TeV with the ATLAS detector

This paper describes a measurement of the W boson transverse momentum distribution using ATLAS pp collision data from the 2010 run of the LHC at root s = 7 TeV, corresponding to an integrated luminosity of about 31 pb(-1). Events form both W -> e nu and W -> mu nu are used, and the transverse momentum of the W candidates is measured through the energy deposition in the calorimeter from the recoil

Shades of professionalism: Risk assessment in pre‐sentence reports in Sweden

Abstract in UndeterminedAn emphasis on risk assessment has been introduced in the instructions guiding pre-sentence reports in Sweden. Since this focus indicates an organizational aspiration to risk management, we examined how pre-sentence assessments are made and especially how probation officers relate to risk assessments. Our results show that probation officers do not act in accordance with th

Impact of sequence diversity in the Moraxella catarrhalis UspA2/UspA2H head domain on vitronectin binding and antigenic variation.

The nasopharyngeal pathogen Moraxella catarrhalis recruits vitronectin to subvert complement-mediated killing. Ubiquitous surface protein (UspA) 2 and its hybrid form UspA2H bind vitronectin at the highly diverse N-terminal head domain. Here we characterized the sequence diversity of the head domain in multiple M. catarrhalis clinical isolates (n = 51) with focus on binding of vitronectin. The hea

Simultaneous growth mechanisms for Cu-seeded InP nanowires

We report on epitaxial growth of InP nanowires (NWs) from Cu seed particles by metal-organic vapor phase epitaxy (MOVPE). Vertically-aligned straight nanowires can be achieved in a limited temperature range between 340 A degrees C and 370 A degrees C as reported earlier. In this paper we present the effect of the V/III ratio on nanowire morphology, growth rate, and particle configuration at a grow

First-line panitumumab plus irinotecan/5-fluorouracil/leucovorin treatment in patients with metastatic colorectal cancer

Purpose Panitumumab monotherapy is approved for KRAS wild-type (WT) metastatic colorectal cancer (mCRC) progressing after standard chemotherapy. This study evaluated first-line panitumumab plus FOLFIRI in patients with mCRC. Methods In this phase II, single-arm study, panitumumab (6 mg/kg) and FOLFIRI [irinotecan (180 mg/m(2)) and leucovorin (400 mg/m(2)) followed by a 5-fluorouracil 400 mg/m(2) b